Oncogenic Viruses Flashcards Preview

Unit 5: Micro > Oncogenic Viruses > Flashcards

Flashcards in Oncogenic Viruses Deck (18)
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1
Q

Describe p53’s mechanism of action

A

If DNA damage is too great, p53 to inhibits the cell cycle and causes apoptosis

2
Q

Describe Rb normal mechnism of action.

A

E2F induces the cell cycle. Rb inhibits the action of E2F.

3
Q

Why is SV40 know as the prototypical DNA tumor virus? What is SV40s mechanism of action?

A

It is a primate virus (not human), that produces a T protein that inhibitis the action of p53 and Rb resulting in cancer growth

4
Q

What cancers do adenovirus cause in humans?

A

They don’t cause cancer in humans. They DO cause cancer in rodents.

5
Q

What type of cancer is HPV typically responsible for in humans?

A

Cervical cancer

6
Q

What two types of cancer is EBV responsible for in humans?

A
  1. Burkitt’s Lymphoma
  2. Naso-pharyngeal cancer
7
Q

What type of cancer does HHV8 typically cause?

A

Kaposi’s Sarcoma

8
Q

What are the high-risk strains of HPV?

A

16,18, 31, 33

9
Q

What is the mechanism of oncogenesis of HPV?

A
  • HPV produces E6 and E7 protein
  • E6 binds to p53
  • E7 binds Rb preventing inhibition of E2F
10
Q

What is the difference between low risk and high risk HPV?

A

Both produce E6 and E7, but the E6 and E7 of low-risk HPV bind with much lower affinity

11
Q

What is the significance of the E2 protein in HPV oncogenesis?

A

E2 (part of the HPV genome) typically suppresses E6 and E7 proteins. Loss of E2 upon HPV gene integration results in over-expression of E6 and E7

12
Q

What is the geographical distribtution of Burkitt Lymphoma and Nasopharyngeal cancer?

A
  • Burkitt - African Malarial Belt
  • Nasopharyngeal - South china, Vietnam
13
Q

Describe the chromosomal changes associated with EBV-relatedlymphomas

A

A 8-14 translocation causes the c-myc gene near an Ig promoter

14
Q

What type of cancer is associated with HBV?

A

Liver cancer

15
Q

What is another name for HHV8?

A

Kaposi Sarcoma Herpes Virus (KSHV)

16
Q

What virus is associated with T cell Leukemia?

A

Human T-cell lymphotropic virus

17
Q

What is the geographic distribution of Human T Cell Leukemia?

A

Caribbean countries

18
Q

What human oncogenic viruses have vaccines?

A
  • HPV - Cervical Cancer
  • HBV - Hepatocellular Carcinoma