Oncologic pt pain and fibromyalgia Flashcards
How does Gabapentin work
inhibits voltage activated calcium channels
Which pathway carries pain
anterolateral pathway:
- spinothalamic (lands on VPL thalamus then cortex)
- spinomesencephalic aka spinotectal tract (synapses on periaqueductal gray which releases endogenous opiods to reduce pain signal reception)
- spinoreticular
Amygdala vs hypothalamus function in pain
amygdala: give emotional relevance
Hypothalamus: initiate autonomic response
Endogenous opiods examples
enkephalins
endorphins
Dynorphins
How does ketamine work
blocks NMDA receptors
What is gate control theory
that rubbing the area activates A beta fibers that activate inhibitory interneurons acting on C fibers and also directly inhibiting second order neurons
What is breakthrough pain
a spike of pain whose magnitude is not covered by the baseline level of analgesic medication the pt is on
