Oncology

Question 1

Oncogene

Answer 1

“Gas Pedal”

Question 2

Tumor Suppressor Gene

Answer 2

“Brakes”

Question 3

Antimetabolites

Answer 3

Block DNA
replication

Question 4

Topoisomerase Inhibitors

Answer 4

Prevent DNA uncoiling

Question 5

Alkylating Agents

Answer 5

Interfere with
DNA base pairing

Question 6

Breast CA Classes

Answer 6

CDK 4/6, HER2, PARP

Question 7

Melanoma Classes

Answer 7

BRAF, MEK

Question 8

Can bill under Part B

Answer 8

TMZ and Cape.

Question 9

Everolimus MOA

Answer 9

mTOR Inh.

Question 10

Alpelisib (Piqray) MOA

Answer 10

PI3K Inh. PLUS Fulvestrant

Question 11

CDK 4/6 Inhibitors

Answer 11

Palbociclib (Ibrance), Ribo-. (Kisqali), Abema-. (Verzenio)

Question 12

Capecitabine Keypoints

Answer 12

BBW: Bleeding risk w/ coumadin, D 1-14 of 21D cycle

Question 13

Everolimus Keypoints

Answer 13

ATC plus Exemestane, HTN, BBW: Immunosuppresion, dexameth. for stomatitis, watch angioedema

Question 14

Piqray Keypoints

Answer 14

ATC plus Fulvestrant, CF, Hyper glycemia

Question 15

Ibrance/Kisqali Keypoints

Answer 15

Add AI or fulvestrant, x21d, monitor ANC (myelosuppression), No grapefruit

Question 16

Verzenio Keypoints

Answer 16

ATC, Can add AI/Fulvestrant OR mono Tx at higher dose, Diarrhea common, No grapefruit

Question 17

HER2 Meds

Answer 17

Nerlynx, Tykerb, Tukysa

Question 18

Nerlynx Keypoints

Answer 18

Diarrhea 95% x56d, avoid grapefruit and antacids, CF

Question 19

Tykerb Keypoints

Answer 19

Hepatotoxicity, Empty stomach, no grapefruit

Question 20

Tukysa Keypoints

Answer 20

Hepatotoxicity

Question 21

PARP Inibitors

Answer 21

Talzenna (Br., Prost.), Lynparza (Br, Ovar., Prost., Pancreatic), Rubraca (Ovarian/Prostate), Zejula (Ovarian)

Question 22

Talzenna Keypoints

Answer 22

BRCA-Mutated, ATC, myelodysplastis syndrome

Question 23

Lynparza Keypoints

Answer 23

BRCA-Mutated, ATC, myelodysplastis syndrome

Question 24

Rubraca, Zejula, Lynparza Keypoints

Answer 24

Both Tx and maint in ovarian, myelodysplastic syndrome

Question 25

EGFR Inhibitor Class ADE's

Answer 25

Rash, Ocular, ILD

Question 26

EGFR Inh. Meds

Answer 26

Tagrisso, Tarceva, Gilotrif, Iressa, Vizimpro

Question 27

Avoid tobacco with this EGFR

Answer 27

Tarceva

Question 28

Which 2 EGFR's do NOT have PPI warnings?

Answer 28

Gilotrif, Iressa

Question 29

Gilotrif and Tarceva with or without food?

Answer 29

Without

Question 30

ALK Inhibitors (3-5% lung CA)

Answer 30

Xalkori, Zykadia, Alecensa, Alunbrig, Lorbrena

Question 31

Which ALK Inh. has loading dose?

Answer 31

Alunbrig

Question 32

Alk Inh. Class ADE's

Answer 32

ILD, Cardiac

Question 33

Alk Inh. Keypoints

Answer 33

Xalkori-Vision disorders, Alecensa-Photosensitivity,

Question 34

ROS1 Inhibitors (1-2% Lung CA; Non-smokers)

Answer 34

Rozlytrek (CHF and bone Fx), Xalkori (ALK and ROS1 MOA)

Question 35

BRAF V600E Mutation

Answer 35

Mekinist, Tafinlar (Combo for lung): Pyrexia, cough, empty stomach

Question 36

NTRK Gene Fusion (<1% Lung CA)

Answer 36

Rozlytek, Vitrakvi