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Capstone Exam 2 > Oncology Brand/Generic/Class/MOA > Flashcards

Oncology Brand/Generic/Class/MOA Flashcards

(64 cards)

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1
Q

Claribine (gen)

A

Anti-metabolite (purine), Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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2
Q

Fludarabine (gen)

A

Anti-metabolite (purine), Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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3
Q

Xeloda

A

Capcitabine (oral), Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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4
Q

ARA-C

A

Citarabine (liposomal), Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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5
Q

5-FU

A

Florouricil, Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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6
Q

Gemzar

A

Gemcitabine, Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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7
Q

Methotrexate (gen)

A

Anti-metabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

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8
Q

Alimta

A

Pemetrexid, Anti-metabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

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9
Q

Pralatrexate (gen)

A

Anti-metabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

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10
Q

Vidaza

A

Azacitidine, Antimetaboite (other), DNA methylation inhibitor
Direct cellular toxicity at abnormal bone marrow cells

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11
Q

Decogen

A

Decitabine, Antimetaboite (other), DNA methylation inhibitor
Direct cellular toxicity at abnormal bone marrow cells

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12
Q

Adriamycin

A

Doxorubucin, Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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13
Q

Doxil

A

Liposomal doxorubucin, Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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14
Q

Danorubucin (gen)

A

Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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15
Q

Epirubucin (gen)

A

Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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16
Q

Vincristine (gen)

A

(Liposomal) Microtubule (vinca alkaloids), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

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17
Q

Vinblastine (gen)

A

Microtubule (vinca alkaloids), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

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18
Q

Vinorelbine (gen)

A

Microtubule (vinca alkaloids), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

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19
Q

Taxol

A

Paclitaxel, Microtubule (Taxanes), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation

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20
Q

Taxotere

A

Docetaxel, Microtubule (Taxanes), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation

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21
Q

Abraxane

A

Paclitaxel- protein bound, Microtubule (Taxanes), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation

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22
Q

Ado-trastuzumab (gen)

A

Microtubule (other)Her-2 antibody conjugate with antimicrotubule inhibitor

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23
Q

Emtansine (gen)

A

Microtubule (other), Her-2 antibody conjugate with antimicrotubule inhibitor

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24
Q

Camptosar

A

Irinotecan, TOPO I inhibitor, Inhibits topo I (stabilizing the cleaved DNA strand, preventing re-ligation)

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25
Hycamtin
Topotecan, TOPO I inhibitor, Inhibits topo I (stabilizing the cleaved DNA strand, preventing re-ligation)
26
Anthracycline (gen)
TOPO II, Inhibits topo II (re-ligation) | Other MOAs too
27
Toposar
Etoposide, TOPO II, Inhibits topo II (re-ligation) | Other MOAs too
28
Cytoxan
Cyclophosphamide, Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage
29
Iposphamide (gen)
Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage
30
Bendamustine (gen)
Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage
31
Carmustine (BCNU) (gen)
Alkylating agents (nitrosoureas), Alkylate DNA, causing cross-linking, inducing strand breakage
32
Lomustine (gen)
Alkylating agents (nitrosoureas), Alkylate DNA, causing cross-linking, inducing strand breakage
33
Streptozocin (gen)
Alkylating agents (nitrosoureas), Alkylate DNA, causing cross-linking, inducing strand breakage
34
Temodar
Dacarbazine, Alkylating agent (triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage.
35
Temozolomide (gen)
ORAL, Alkylating agent (triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage.
36
Matulane
Procarbazine (oral), Alkylating agent (other), Inhibits transmethylation of methionine into tRNA; insight strand breakage
37
Carboplatin (gen)
``` Alkylating agent (platinum), Insights cross-linking Violates the double-helix structure Strand breakage ```
38
Cisplatin (gen)
``` Alkylating agent (platinum), Insights cross-linking Violates the double-helix structure Strand breakage ```
39
Eloxitan
Oxaloplatin, Alkylating agent (platinum), Insights cross-linking Violates the double-helix structure Strand breakage
40
Bleomycin (gen)
Antibiotic, Inhibits synthesis of DNA | And causes ROS
41
Hydrea
Hydroxyurea (oral), Misc,Antimetabolite inhibiting ribonucleoside diphosphate reductase, preventing conversion of ribonucleotides to deoxyribonucleotides  halting cell cycle Increases Hgb F levels
42
Mitomycin-C (gen)
Misc, Alkylating agent, creates cross-linking with guanine and cytosine pairs.
43
Tarceda
Erlotinib (oral), Anti-EGFR ORAL, EGFR selective TKI.
44
Tykerb
Lapatinib (oral), EGFR and HER2 TKI.
45
Gleevac
Imatinib (oral), BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML *T351I mutation
46
Dasatinib (gen)
BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML *T351I mutation
47
Iclusig
Ponatinib (oral), BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML *T351I mutation
48
Sutent
Sunitinib (oral), Kinase inhibitor, inhibit multiple receptor TKs.
49
Nexavar
Soratenib (oral), Kinase inhibitor, inhibit multiple receptor TKs.
50
Axitinib (oral)
Kinase inhibitor, inhibit multiple receptor TKs.
51
Valcade
Bortezomib, proteosome inhibitor, Inhibits proteasomes, critical for protein homeostasis, inducing apoptosis
52
Xalkori
Citotinib (oral), misc, ALK inhibition, ALK is a down-stream mutation causing constant “on” of proliferation; used in NSCLC
53
Zykadia
Ceritinib (oral), misc, ALK inhibition, ALK is a down-stream mutation causing constant “on” of proliferation; used in NSCLC
54
Jakafi
Ruxolitinib, misc, JAK1, JAK2 inhibition of the JAK-STAT signaling pathway. Used in myeloproliferative disorders with JAK2 mutations
55
Rituxan
Rituximab, Anti-CD 20, Binds to CD20 on B cells, induces ADCC
56
Azerra
Ofatumumab, Anti-CD 20, Binds to CD20 on B cells, induces ADCC
57
Campath
Alemtuxumab, Anti-CD 52, Binds to CD 52 on B and T cells, inhibits interaction with other immune system functions, induces ADCC
58
Erbitux
Certuximab, EGFR, Bind to and inhibit extracellular EGFR, induces apoptosis
59
Herceptin
Trastuzumab, Her 2, Binds to HER2 at different points on the receptor, induces ADCC
60
Perjeta
Pertuzumab, Her 2, Binds to HER2 at different points on the receptor, induces ADCC
61
Ado-trastuzumab (gen)
Her 2, Binds to HER2 at different points on the receptor, induces ADCC
62
Avastin
Bevacizumab, VEGF, Binds to circulating VEGF, inhibits the formation for vasculature, required for tumor growth
63
Yervoy
Ipilimumab, CTLA-4, Binds to cytotoxic T-lymphocyte associated antigen 4 (CTLA-4), enhancing T-cell activation
64
Aldesleukin
IL-2, Interferon, Cytokine, promoting B and T cell proliferation, anti-cancer therapy based on tumor susceptibility to lymphokine-activated killer cells and tumor-infiltrating lymphocytes

Capstone Exam 2 (8 decks)

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