Oncology drugs

Question 1

Alectinib and Crizotinib target is?

Answer 1

ALK

Question 2

For what pathology do you use Alectinib and Crizotinib?

Answer 2

Non-small lung cancer

Question 3

Which adverse effects do Alectibin and Crizotinib have?

Answer 3

Edema, rash, and diarrhea

Question 4

What is the target of Erlotinib, Gefitinib, and Afatinib

Answer 4

EGFR

Question 5

For which pathology are Erlotinib, Gefitinib, and Afatinib used?

Answer 5

Non-small lung cancer

Question 6

Which adverse effects do Erlotinib, Gefitinib, and Afatinib have?

Answer 6

Rash and diarrhea.

Question 7

What is the target of Imatinib, dasatinib, and nilotinib?

Answer 7

BRC-ABL and other tyrosine kinases

Question 8

For which pathology are Imatinib, Dasatinib and Nilotinib used?

Answer 8

CML, ALL and GIST

Question 9

Which adverse effects do Imatinib, Dasatinib, and Nilotinib have?

Answer 9

Myelosuppression, increase in liver function test, edema, and myalgia

Question 10

What is the target of Ruxolitinib?

Answer 10

JAK 1/2

Question 11

For which pathology is Ruxolitinib used

Answer 11

Polycythemia Vera

Question 12

What are the side effects of Ruxolitinib

Answer 12

Bruises and increase in liver function tests.

Question 13

What is the target of Bortezomib, Ixazomib, and Carfilzomib?

Answer 13

Proteosomes

Inducing arrest G2 to M phase through the accumulation of abnormal proteins.

Question 14

For which pathology are Bortezomib, Ixazomib, and Carfilzomib used?

Answer 14

Multiple Myeloma, Mantle cell lymphoma

Question 15

What are the side effects of Bortezomib, Ixazomib, and Carfilzomib?

Answer 15

Peripheral neuropathy and Herpes Zoster reactivation ( due to a decrease in T cells)

Question 16

What is the target of Vemurafenib, Encorafenib and Dabrafenib?

Answer 16

BRAF

Question 17

For which pathology are Vemurafenib, Encorafenib, and Dabrafenib used?

Answer 17

Melanoma, and is co-administered with Trametinib ( which is a MEK inhibitor)

Question 18

Side effects of Vemurafenib, Encorafenib and Dabrafenib?

Answer 18

Rash, Fatigue, Nausea and Diarrhea.

Question 19

What is the target of Palbociclib?

Answer 19

CDK 4 and 6

Which induces arrest at G1-S phase

Question 20

For which pathology is Palbociclib used?

Answer 20

Breast Cancer

Question 21

Which are the side effects of Palbociclib?

Answer 21

Myelosuppression and Pneumonitis

Question 22

What is the target of Olaparib

Answer 22

ADP-Ribose Polymerase

which decreases DNA repair

Question 23

For which pathology is Olaparib used?

Answer 23

Breast, Ovarian, Pancreatic, and Prostate Cancer.

Question 24

Which are the side effects of Olaparib

Answer 24

Myelosuppression, Edema, and diarrhea.

Question 25

Cisplatin, Carboplatin, and Oxaliplatin mechanism is

Answer 25

cross-link of DNA.

Question 26

Cisplatin, Carboplatin, and Oxaliplatin are used for

Answer 26

Solid tumors and lymphoma.

Question 27

What are the side effects of Cisplatin, Carboplatin, and Oxaliplatin?

Answer 27

Peripheral Neuropathy Ototoxic Nephrotoxic = Fancony which can be prevented with Amifostine.

Question 28

how can we prevent Fancony when using Platinum compounds

Answer 28

Amifostine

Question 29

PD-1 Antibodies

Answer 29

Cemiplimab, Nivolumab, Pembrolizumab

Question 30

PD-L1 Antibodies

Answer 30

Atezolimumab, Durvalumab, Avelumab

Question 31

Antibodies against CTLA- 4

Answer 31

Ipilimumab

Question 32

Monoclonal antibodies are eliminated by

Answer 32

Macrophages

Question 33

Alemtuzumab target

Answer 33

CD52

Question 34

What do I use Alemtuzumab for?

Answer 34

Chronic Lymphocytic Leukemia (CLL) LEM = LYM and for Multiple Sclerosis

Question 35

Target of Bevacizumab

Answer 35

VEGF

Question 36

what do I use Bevacizumab for

Answer 36

Colorectal cancer, RCC, Non-small lung CA, antiproliferative retinopathy

Question 37

Side effects of Alemtuzumab

Answer 37

increase risk of infections and autoimmunity

Question 38

side effects of Bevacizumab

Answer 38

Blood clots, Hemorrhage, impaired wound healing.

Question 39

Target Cetuximab and Panitumumab

Answer 39

EGFR

Question 40

What do i use Cetuximab and Panitumumab for

Answer 40

Metastatic CRC ( wild type RAS) and for neck/head cancer

Question 41

Side effects of Cetuximab and panitumumab

Answer 41

Rash, elevated liver function tests, diarrhea.

Question 42

Use of Rituximab

Answer 42

Non- Hodgkin lymphoma, CLL, Rheumatoid Arthritis, ITP, TTP, AIHA, multiple sclerosis

Question 43

Adverse effect of rituximab

Answer 43

Infusion reaction = cytokine release = target on B cells

Question 44

Trastuzumab use

Answer 44

breast cancer and gastric cancer

Question 45

Side effects of trastuzumab

Answer 45

Dilated cardiomyopathy which is reversible