Oncology + Heam

Question 1

In ALL which cytogenetic feature carries the worst prognosis?

Answer 1

translocation (9;22)

Philidelphia chromosome

Question 2

Toxicity of methotrexate is related to what?

Answer 2

Length of time of exposure

(good renal function, well hydrated patient)
–> any drug which affects renal clearance increases risk of methotrexate toxicity

Question 3

Which condition requires trephine BMA for diagnosis?

Answer 3

Aplastic anaemia (defined by empty BM)

Question 4

Features of veno-occlusive disease? (3)

Answer 4

Tender hepatomegaly
Jaundice (usu conjugated)
Hypoalbuminemia with ascites and weight gain

Question 5

Risk factors for GvHD post BMT?

Answer 5

HLA mismatch
unrelated donor
older age of both donor and recipient (worse)
higher radiation dose
acute or relapsed malignancy at transplant

Question 6

Raised B-HCG with any tumour is indicative of what?

Answer 6

Germ cell tumour (NGGCT)

Question 7

What is the best measure of prognosis in ALL?

Answer 7

MRD

Question 8

What is the big bad long term SE of anthracyclines (doxorubacin/danorubacin)?

Answer 8

Cardiac toxicity (related to length of exposure

Question 9

First order kinetics refers to?

Answer 9

killing a constant FRACTION of cancer cells

Question 10

Zero order kinetics refers to?

Answer 10

Drug is metabolised at constant number (despite concentration)

Question 11

Which type of von Willebrand disease is inherited in an AR fashion?

Answer 11

type 3