What is the clinical importance of aqueous humor drainage in glaucoma?
raised intra-ocular pressure is caused by imbalance between rate of secretion and removal of aqueous humor
What treatment can reduce intraocular pressure when it starts to cause glaucoma?
- Carbonic anhydrase inhibitors: reduce aqueous humor production
what are 2 examples of carbonic anhydrase inhibitors
- Dorzolamide: administered as eye drops, nos systemic side effects
- Acetazolamide: oral administration, SE: acidosis, as it also targets kidney
What is the clinical importance of iridocorneal angle in terms of glaucoma and aqueous humor drainage? (ie, open and close angle glaucoma)
- open-angle glaucoma: allows aqueous humor drain out of eye but drainage channels might clog over time-> increased eye pressure and damage to the optic nerve
- closed-angle glaucoma: prevent the aqueous humor from draining out of the eye->sudden increase in eye pressure, painful and damage optic nerve quickly.