Opie Nitrates

Question 1

Nitrates provide an exogenous source of ___ inducing ____

Answer 1

nitric oxide; inducing coronary vasodilation

Question 2

Nitrates at least in human medicine are used as ___

Answer 2

antianginas

Question 3

Nitrates preferentially dilate ___ and ___ greater than ___ mm in diameter

Answer 3

dilate large coronary arteries and arterioles greater than 100 mm in diameter

Question 4

Effects of nitrates dilating coronary arteries and arterioles do 2 things

Answer 4

1) redistribute blood flow along collateral channels and from epicardial to endocardial regions
2) relieve coronary vasospasm and dynamic epicardial stenosis, including the coronary arterial constriction that may be induced by exercise and thereby relieving exercise-induced myocardial ischemia