Opiods

Question 1

MoA for Opioid agonists

Answer 1

Activation of opiod Gi/o coupled receptors

Inhibit neurotransmission

Question 2

What are Schedule I, II, III, IV drugs

Answer 2

I- heroin
II: Morphine
III: Buprenorphine
IV: Butorphanol, tramadol

Question 3

Main pharacological effect from opioids?

Answer 3

analgesia
some sedation
antitussive
respiratory depression

Question 4

When should you not use opiods?

Answer 4

head injuries
decreased GI motility
Cardiac/Respiratory Dz, Renal failure

Question 5

Full u agonists

Answer 5

Morphine
Hyromorphone
Fentanyl
Carfentanil

Question 6

Difference between Morphine and Hydromorphine

Answer 6

Hydromorphine causes less histamine release

Morphine is used in epidurals

Question 7

Fentanyl

Answer 7

full u agonist

fast onset, short duration, good for CRI, transdermal

Question 8

Carfentanil/Etorphine

Answer 8

way more potent than morphine

Used in wild life darting

Question 9

Buprenorphine

Answer 9

partial u agonist

good as transmucosal for crazy ass cats

Question 10

Butorphanol

Answer 10

k Agonist and u ANTagonist
better for visceral pian
analgesial lower ceiling effect than mu agonists
common opiod for equines
can be used in small animal to reverse full mu agonist

Question 11

Naloxone

Answer 11

Full opioid ANTagonist

Question 12

Naltrexone and Diprenophine

Answer 12

used to reverse carfentanil and etorphine

Question 13

Hydrocodone

Answer 13

opioid used as an antitussive

DEA Schedule II drug