Opioid Agonists-Antagonists Flashcards
(36 cards)
if a pt has pure opioid agonist intolerance we can give them
opioid agonist-antagonists
a-a’s have partial to no effect on these receptors
mu
a-a’s have partial effects here causing dysphoria
kappa and delta
advantages of using a-a’s
analgesia, decreased physical dependence, decreased RD, and ceiling effect
pentazocine has agonist effects on _____ and ______ and has weak _______ effects
kappa and delta; antagonist
due to some antagonism, pentazocine may cause
withdrawal symptoms
pentazocine has extensive
hepatic first pass effect (80%)
e 1/2 time of pentazocine
2-3 hours
excretion of pentazocine
kidneys; glucoronidation
pentazocine has a shorter duration than morphine in
epidurals
common s/e of pentazocine
sedation, sweating, dizziness, and dysphoria; catecholamine release causing increases in hr, bp, PA bp, and LVEDP
pentazocine crosses the _____ barrier
placental
high doses of pentazocine may cause
feeling of impending death
pentazocine may be used for
moderate chronic pain relief
butorphanol is more potent than
pentazocine
butorphanol affinities? what will this cause?
low mu, low sigma, moderate kappa; less dysphoria and more analgesia and anti shivering effects
we have rapid and complete absorption when we give butorphanol
IM
butorphenol e 1/2 time
2.5-3.5 hours
butorphanol elimination
more in bile than urine
unique s/e of butorphenol
sweating, still has dysphoria
caution with butorphenol
difficult to use with other opioid agonists
nalbuphine is equally potent to
morphine
nalbuphine is a ___ agonist
mu
e 1/2 time of nalbuphine
3-6 hours
