Opioids Flashcards
(39 cards)
1
Q
pKa of Morphine
A
8
2
Q
pKa of Buprenorphine
A
8.3
3
Q
pKa of Codeine
A
8.2
4
Q
pKa of Pethidine
A
8.5
5
Q
pKa of Fentanyl
A
8.4
6
Q
pKa of Alfentanyl
A
6.5
7
Q
pKa of Remifentanyl
A
7.1
8
Q
PPB of Fentanyl (%)
A
80
9
Q
PPB of Alfentanyl (%)
A
90
10
Q
PPB of Remifentanyl (%)
A
70
11
Q
PPB of Morphine (%)
A
30
12
Q
PPB of Pethidine (%)
A
40
13
Q
PPB of Codeine (%)
A
25
14
Q
PPB of Buprenorphine (%)
A
95
15
Q
T1/2 of Morphine
A
3h
16
Q
T1/2 of Pethidine
A
4h
17
Q
T1/2 of Codeine
A
3h
18
Q
T1/2 of Buprenorphine
A
75h
19
Q
T1/2 of Fentanyl
A
3h30
20
Q
T1/2 of Alfentanyl
A
1h30
21
Q
T1/2 of Remifentanyl
A
3.6min
22
Q
Vd of Morphine (L/kg)
A
3-5
23
Q
Vd of Pethidine (L/kg)
A
3-5
24
Q
Vd of Codeine (L/kg)
A
3.6
25
Vd of Buprenorphine (L/kg)
2.8
26
Vd of Fentanyl (L/kg)
3-5
27
Vd of Alfentanyl (L/kg)
0.4 - 1.0
28
Vd of Remifentanyl (L/kg)
0.2 - 0.3
29
CL of Morphine (ml/min/kg)
15 - 30
30
CL of Pethidine (ml/min/kg)
8 - 18
31
CL of Codeine (ml/min/kg)
0.85
32
CL of Buprenorphine (ml/min/kg)
20
33
CL of Fentanyl (ml/min/kg)
0.8 - 1.0
34
CL of Alfentanyl (ml/min/kg)
4 - 9
35
CL of Remifentanyl (ml/min/kg)
30 - 40
36
Relative lipid solubility of Pethidine
(compared to Morphine)
28
37
Relative lipid solubility of Fentanyl
(compared to Morphine)
580
38
Relative lipid solubility of Alfentanyl
(compared to Morphine)
90
39
Relative lipid solubility of Remifentanyl
(compared to Morphine)
50
