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Flashcards in opioids Deck (10):
1

what is an opiate

derived form alkaloids of the opium poppy

2

what is an opioid

natural and synthetic drug which mimic morphone

3

what ia analgesia

state in which no pain is perceived despite the presence of a stimulus that would normally cause pain

4

what is the MOA of opioid analgesics

-act by binding to receptors for endogenous opioids
-G protein of adenylyl cyclase activity
-close presynaptic voltage gated Ca++ channels
-reduces neurotransmitter release of: NE, substance P, Ach, glutamate, serotonin
-open postsynaptic K+ channels; hyper polarizes and inhibits activity

5

what are the endogenous opioid peptides

-Enkephalins (from the head)
-Endorphins (endogenous opiate)
-Dynorphins (dynamic opiate)

6

what is the precursor of enekphalins

proenkephalin

7

what is the precursor of endorphins

proopiomelanocortin

8

what is the precursor of dynorphins

prodynorphin

9

where are endogenous opioid precursors found

at sites associated w/ pain modulation

10

where do endogenous opioid peptides action occur

-effects occur at the spinal and supra spinal levels and at the peripheral endings of sensory nerves