Flashcards in Opioids Deck (13):
What is the opiod toxidrome?
· Miosis, respiratory depression, CNS depression
How does clonidine work for opiate withdrawal
Clonidine binds to alpha 2 adrenergic receptos which stimulates K+ efflux the same way that opioids do
How are opioids metabolized?
- Hepatically (has implications for liver failure – prolonged half life)
How are opioids eliminated?
What opioids are associated with seizures?
- Meperidine (its metabolitem: normeperidine)
What are the half-lives of heroin and methadone? How does this affect the onset of withdrawal symptoms after cessation?
Heroin: T1/2= 30 min WD after 4-6 hrs
Methadone: T1/2 15-40hr
What route of opioid abuse is associated with spongiform leukoencephalopathy?
“Chasing the dragon” – Inhalation of heated heroin
List symptoms of spongiform leukoencephalopthy
- Psychomotor retardation
- Other neurologic abnormalities
What opioids can precipitate the serotonin syndrome?
What opioid does not cause meiosis
What mechanisms contribute to nausea and vomiting caused by opioids?
- Delayed gastric emptying
- Direct stimulation of chemoreceptor trigger zone
What is the differential for opiate intoxication?
- Sedative hypnotics
- Brainstem or pontine infarct