opoids

Question 1

what are the opoid receptors?

Answer 1

1. mu (most effective receptor)
2. delta
3. kappa

Question 2

MOA of opoids

Answer 2

1. opoid binds to opoid receptors (u/k/g) coupled to G1 protiens (GPCR)
2. calcium channels close, inhibit calcium entry
3. hyperpolarisation occur
4. block neurotransmission

Question 3

Name strong opoids

Answer 3

1. morphine
2. fentanyl
3. methadone
4. pethidine

Question 4

Name weak opoids

Answer 4

1. codeine
2. tramadol

Question 5

morphine

Answer 5

• analgesic
• strong u agonist
• weak k and delta agonist
• high max analgesic efficacy

Question 6

morphine AE

Answer 6

• addiction
• histamine release=> urticaria, bronchoconstriction, hypotension

Question 7

methadone and fentanyl

Answer 7

• fentanyl ( anesthetic, short acting)
• methadone ( long acting)
• strong u agonist
• no k and delta
• high max analgesic efficacy

Question 8

methadone and fentanyl AE

Answer 8

high liability for abuse and addiction

Question 9

pethidine

Answer 9

• strong u agonist
• weak k and delta
• shorter doa than morphine
• analgesic in labour

Question 10

pethidine AE

Answer 10

• antimuscarinic : dry mouth, hypertension
• restlessness since not sedation

Question 11

codeine

Answer 11

• analgesic and cough suppressant
• weak u and delta
• moderate liability for addiction

Question 12

tramadol

Answer 12

weak u agonist
weak inhibtor of 5HT and NA reuptake

Question 13

dose dependent effect

Answer 13

1. reduced gut motility
2. euphoria (high)
3. pupil constriction
4. constipation
5. dysphoria (stress, anxiety, depression)
6. severe sedation
7. respiratory d