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My Obesity Pharmacotherapy > Optimizing Obesity Treatment Using Medication Combinations > Flashcards

Optimizing Obesity Treatment Using Medication Combinations Flashcards

1
Q

Where does topiramate act on the brain?

A

GABAergic receptors

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2
Q

What parts of the brain do Naltrexone interact with

A

POMC/CART

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3
Q

What parts of the brain do bupropion interact with

A

VTA

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4
Q

What parts of the brain do phentermine interact with

A

VTA

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5
Q

What parts of the brain do liraglutide interact with

A

POMC/CART

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6
Q

Choice of obesity medications for binge eating

A

lisdexamphetamine

phentermine/topiramate (qysmia)

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7
Q

Choice of obesity medications for depression

A

bupropion

naltrexone/bupropion

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8
Q

Choice of obesity medications for anxiety

A

topiramate

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9
Q

Choice of obesity medications for “sugar addiction”

A

naltrexone

topiramate (soda)

naltrexone/bupropion

phentermine/topiramate

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10
Q

Choice of obesity medications for “fat addiction”

A

naltrexone/bupropion

orlistate

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11
Q

Choice of obesity medications for ADHD

A

bupropion

lisdexamphetamine

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12
Q

Choice of obesity medications for volume eater

A

liraglutide

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13
Q

Choice of obesity medications for compulsive behaviors

A

bupropion

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14
Q

Choice of obesity medications for low metabolic rate

A

phentermine

phentermine/topiramate

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15
Q

Which two medication combinations should i never use

A

contrave and qsymia

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16
Q

Reasons to choose phentermine

A

inexpensive, time tested

17
Q

Reasons to not choose phentermine

A

stimulant side effects - anxiety, irritability

schedule 4 controlled substance

known cardiac dz

18
Q

reasons to choose topiramate

A

double benefits for migraines, sz, binge eating, bipolar

may help insomnia, reduce soda intake excessive carb intake

inexpensive

19
Q

reasons to NOT choose topomax

A

cognitive, word finding difficulty

teratogenic effect (planning to be preggers)

20
Q

reasons to choose qsymia

A

double benfits for migraines, sz, binge eating, bipolar

may help insomnia, reduce soda intake, escessive carb intake

highly effective

21
Q

reasons to NOT choose qsymia

A

stimulant effect

teratogenic effect

expensive

hx of kidney stones or glaucoma

22
Q

reasons to choose saxenda

A

double benefits for DM

Improves HTN, cardiovascular risk

lack of central effects

highly effective

23
Q

reasons to NOT choose saxenda

A

gastroparesis

history MTC

history of pancreatitis

expensive

24
Q

reasons to choose contrave

A

double benefits ETOH and smoking cessation

helps iwth depression

DM improvement

helps with excessive cravings, hedonistic food drive

25
Q

reasons to NOT choose contrave

A

stimulant side effects

nausea (naltrexone)

expensive

hx of sz

uncontrolled HTN

active bullemia

less effective

26
Q

reasons to choose orlistate

A

hyperTG

no central side effects

27
Q

reasons to NOT choose orlistat

A

less effective

GI side effect profile

B12 deficiency

28
Q

reasons to choose metformin

A

double benefit for PCOS, DM, atypical antipsych meds

can be used in pregnancy

inexpensive

29
Q

reasons to NOT choose metformin

A

GI side effect profile

B12 deficiency

My Obesity Pharmacotherapy (2 decks)

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