Oral Med Flashcards
(61 cards)
What is ulceration
Localised defect, where there is destruction of epithelium exposing underlying connective tissue
Causes of ulcers
Traumatic
Metabolic/nutritional
Allergic/hypersensitivity
Infective
Inflammatory
Immunological
Drug induced (iatrogenic)
Neoplastic
“Idiopathic”
What would a traumatic ulcer look like
White (keratotic) borders
Clear causative agent
Surrounding mucosa normal and ulcer soft
What would a metabolic and nutrtitonal ulcer look like and cause
Apthous like ulcers yellow/white with red border
In kids it can be growth
In adults GI/GU pathology or malnourishment or anaemia
What are the 2 forms of gut disease that could cause ulceration and exanples
Malabsorption
-Crohn’s disease/Coeliac disease/Ulcerative colitis/pernicious anaemia
Blood loss
-IBD/Peptic or duodenal ulcers/colonic polyps/colon cancer
What does iron folate or B12 deficiency cause that makes it more prone to ulceration
Atrophy of mucosa
What food stuffs could cause an allergy or hypersensitivity ulcer
Sorbate: canned fruit, cheeses
Cinnamaldehyde: Sweets, chewing gum
Benzoates: fizzy drinks, fruit juice
What inflammatory or immunological causes of ulceration is there
Behcet’s
Necrotising sialometaplasia
Lichen Planus
Vesiculobullous Disease
Connective Tissue Disease: Systemic Lupus Erythematous, Rheumatoid Arthritis, scleroderma
What could be an infective cause of ulceration
Primary or recurrent herpes simplex virus infection
Varicella-zoster virus
Epstein-Barr virus
Coxsackie virus
EchovirusTreponema pallidum
Mycobacterium tuberculosis
Chronic mucocutaneous candidiasis
HIV
What could Varicella-zoster virus lead to
Virus Remains latent in sensory ganglion then Reactivation often due to immunocompromisation or other acute infection leading to Reactivation of
latent virus resulting in shingles
Will present over the distribution of a dermatome
Tx varicella zoster
Liaise with the patients GP: they may need further
investigations, provide analgesia and difflam if painful
What could a iatrogenic cause of ulceration be
Chemotherapy
Radiotherapy
Graft versus Host Disease
Drug Induced Ulceration
-Potassium channel blockers,bisphosphonates, NSAIDS, DMARDs
What does a neoplastic ulcer look like
Exophytic
Rolled borders
Raised
Hard to touch
Non Moveable
Not always painful
Sensory disturbance
What is the management of oral ulceration
Reverse the reversible (diet etc)
Refer for FBC/B12/Folate/Ferritin/Coeliac Screen
1.Simple mouthwash (HSMW)
2.Antiseptic mouthwash (hydrogen peroxide or CHX)
3.Local anaesthetic (Benzydamine or lidocaine)
4.Steroid mouthwash (Betamethasone)
5.Onward referral to Oral Medicine
-Excluding other associated pathology
-Explore other therapeutic options such a colchicine or dapsone
What is Low ferritin – associated with a LOW Mean cell volume and Low B12/Folate – associated with a HIGH mean cell volume
Low ferritin – associated with a LOW Mean cell volume (MCV) - Microcytic
Low B12/Folate – associated with a HIGH mean cell volume - Normocytic
What types of lichen planus is there and what do they look like
Reticular
-White lace like pattern
Atrophic
-Inflamed areas, with thinned red epithelium
Bullous
-Blistered appearance, with ulceration
Erosive
-Atrophic appearance with ulceration
Plaque-like
-White plaques
Papular
-Small white papules
What is the %’s of lichen palnus and malignancy chance
Effects 0.5 – 2%
1% over 10 year risk of malignant change
Differnt terms of LP and what it means
Oral Lichen Planus- idiopathic
Oral Lichenoid Reactions- causitive agent
What is management of OLP/OLR
Symptomatic relief:
1.Simple mouthwash
2.Local anaesthetic (Benzydamine or lidocaine)
- Avoid trigger factors: Spicy foods, fizzy drinks
- Steroid mouthwash
- Change restorations
- Onward Referral- Biopsy, stopping the cause in OLR
- If managing in general dental practice, review regularly
- Inform of increased cancer risk, but put this in context, the risk of change is low
What are the vesiculobullous diseases
Mucous membrane pemphigoid
Pemphigus vulgaris
Erythema multiforme
What is the management of vesiculobullous diseases
Provide symptomatic relief and refer to OM
-Betamethasone mouthwash
-Difflam
Management in Oral Medicine – Liaise and investigate with biopsy, blood tests and provide long-term treatment
OM drugs-Prednisolone (pulsed), Doxycycline, Azathioprine, Mycophenolate mofetil, Methotrexate
Aetiology of Erythema multiforme
Hypersensitivity
Infective – Herpes simplex virus (HSV-1) in 15-20%
Drugs – allopurinol, carbamazepine, NSAIDs, phenytoin
Following BCG or Hep B immunisations
Management for EM
Refer to OM for advice
Topical steroids for oral lesions (minor EM)
Systemic steroids for more severe disease
Adjunctive oral care (ohi, CHX, comfort measures)
Antihistamines for skin itch
Stop any obvious precipitating medication
Consider inpatient admission
Recurrent EM
Consideration of immunosuppression (Aza, MMF) – risk/benefit
Prophylactic aciclovir (due to HSV implication)
Recurrence rate of EM
up to 25%