Oral Med Flashcards

(61 cards)

1
Q

What is ulceration

A

Localised defect, where there is destruction of epithelium exposing underlying connective tissue

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2
Q

Causes of ulcers

A

Traumatic
Metabolic/nutritional
Allergic/hypersensitivity
Infective
Inflammatory
Immunological
Drug induced (iatrogenic)
Neoplastic
“Idiopathic”

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3
Q

What would a traumatic ulcer look like

A

White (keratotic) borders

Clear causative agent

Surrounding mucosa normal and ulcer soft

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4
Q

What would a metabolic and nutrtitonal ulcer look like and cause

A

Apthous like ulcers yellow/white with red border

In kids it can be growth

In adults GI/GU pathology or malnourishment or anaemia

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5
Q

What are the 2 forms of gut disease that could cause ulceration and exanples

A

Malabsorption
-Crohn’s disease/Coeliac disease/Ulcerative colitis/pernicious anaemia

Blood loss
-IBD/Peptic or duodenal ulcers/colonic polyps/colon cancer

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6
Q

What does iron folate or B12 deficiency cause that makes it more prone to ulceration

A

Atrophy of mucosa

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7
Q

What food stuffs could cause an allergy or hypersensitivity ulcer

A

Sorbate: canned fruit, cheeses

Cinnamaldehyde: Sweets, chewing gum

Benzoates: fizzy drinks, fruit juice

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8
Q

What inflammatory or immunological causes of ulceration is there

A

Behcet’s

Necrotising sialometaplasia

Lichen Planus

Vesiculobullous Disease

Connective Tissue Disease: Systemic Lupus Erythematous, Rheumatoid Arthritis, scleroderma

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9
Q

What could be an infective cause of ulceration

A

Primary or recurrent herpes simplex virus infection
Varicella-zoster virus
Epstein-Barr virus
Coxsackie virus
EchovirusTreponema pallidum
Mycobacterium tuberculosis
Chronic mucocutaneous candidiasis
HIV

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10
Q

What could Varicella-zoster virus lead to

A

Virus Remains latent in sensory ganglion then Reactivation often due to immunocompromisation or other acute infection leading to Reactivation of
latent virus resulting in shingles

Will present over the distribution of a dermatome

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11
Q

Tx varicella zoster

A

Liaise with the patients GP: they may need further
investigations, provide analgesia and difflam if painful

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12
Q

What could a iatrogenic cause of ulceration be

A

Chemotherapy

Radiotherapy

Graft versus Host Disease

Drug Induced Ulceration
-Potassium channel blockers,bisphosphonates, NSAIDS, DMARDs

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13
Q

What does a neoplastic ulcer look like

A

Exophytic

Rolled borders

Raised

Hard to touch

Non Moveable

Not always painful

Sensory disturbance

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14
Q

What is the management of oral ulceration

A

Reverse the reversible (diet etc)

Refer for FBC/B12/Folate/Ferritin/Coeliac Screen

1.Simple mouthwash (HSMW)
2.Antiseptic mouthwash (hydrogen peroxide or CHX)
3.Local anaesthetic (Benzydamine or lidocaine)
4.Steroid mouthwash (Betamethasone)
5.Onward referral to Oral Medicine
-Excluding other associated pathology
-Explore other therapeutic options such a colchicine or dapsone

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15
Q

What is Low ferritin – associated with a LOW Mean cell volume and Low B12/Folate – associated with a HIGH mean cell volume

A

Low ferritin – associated with a LOW Mean cell volume (MCV) - Microcytic

Low B12/Folate – associated with a HIGH mean cell volume - Normocytic

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16
Q

What types of lichen planus is there and what do they look like

A

Reticular
-White lace like pattern

Atrophic
-Inflamed areas, with thinned red epithelium

Bullous
-Blistered appearance, with ulceration

Erosive
-Atrophic appearance with ulceration

Plaque-like
-White plaques

Papular
-Small white papules

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17
Q

What is the %’s of lichen palnus and malignancy chance

A

Effects 0.5 – 2%

1% over 10 year risk of malignant change

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18
Q

Differnt terms of LP and what it means

A

Oral Lichen Planus- idiopathic

Oral Lichenoid Reactions- causitive agent

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19
Q

What is management of OLP/OLR

A

Symptomatic relief:

1.Simple mouthwash

2.Local anaesthetic (Benzydamine or lidocaine)

  1. Avoid trigger factors: Spicy foods, fizzy drinks
  2. Steroid mouthwash
  3. Change restorations
  4. Onward Referral- Biopsy, stopping the cause in OLR
  5. If managing in general dental practice, review regularly
  6. Inform of increased cancer risk, but put this in context, the risk of change is low
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20
Q

What are the vesiculobullous diseases

A

Mucous membrane pemphigoid

Pemphigus vulgaris

Erythema multiforme

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21
Q

What is the management of vesiculobullous diseases

A

Provide symptomatic relief and refer to OM
-Betamethasone mouthwash
-Difflam

Management in Oral Medicine – Liaise and investigate with biopsy, blood tests and provide long-term treatment

OM drugs-Prednisolone (pulsed), Doxycycline, Azathioprine, Mycophenolate mofetil, Methotrexate

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22
Q

Aetiology of Erythema multiforme

A

Hypersensitivity

Infective – Herpes simplex virus (HSV-1) in 15-20%

Drugs – allopurinol, carbamazepine, NSAIDs, phenytoin

Following BCG or Hep B immunisations

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23
Q

Management for EM

A

Refer to OM for advice

Topical steroids for oral lesions (minor EM)

Systemic steroids for more severe disease

Adjunctive oral care (ohi, CHX, comfort measures)

Antihistamines for skin itch

Stop any obvious precipitating medication

Consider inpatient admission

Recurrent EM

Consideration of immunosuppression (Aza, MMF) – risk/benefit

Prophylactic aciclovir (due to HSV implication)

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24
Q

Recurrence rate of EM

A

up to 25%

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25
What could a cause of white or red patch be
White ➔ more keratin, hyperkeratosis Red ➔ atrophy, hyperaemia or loss of keratinisation
26
What are the red flags for SCC
> 3-week duration > 50 years old Smoking High alcohol consumption History of oral cancer Non-homogenous Non-healing ulceration Induration Exophytic Tethering of tissue Tooth mobility Non-healing extraction sockets Difficulty speaking/swallowing Cervical Lymphadenopathy Weight loss/appetite loss/fatigue Numbness/altered sensation
27
Types of leukoplakia
Homogeneous leukoplakia: It is uniformly white, flat and thin, has a smooth surface, and may exhibit shallow cracks. Verrucous leukoplakia : The surface is raised, exophytic, wrinkled or corrugated
28
malignancy chance of leukoplakia
Difficult to predict which will progress to cancer 0.13 – 34%
29
What are features and parameters that have a strong association to cancer
if size >200mm If texture non-homogeneous If colour red or speckled If site FOM or tongue If dyspalsia is severe or high risk of dysplasia
30
What should be excluded from a diag of leukoplakia
Leukoedema White sponge nevus Frictional keratosis Chemical injury Acute pseudomembranous candidiasis Hairy leukoplakia Lichen planus (plaque-like variant) Lichenoid reaction (local factors and medications) Discoid lupus erythematosus
31
What is the management of a leukoplakia lesion
32
What is the general management olf a white lesion
Thorough History, examination and System enquirey Exclude red flags Does it wipe away? Get photos Is there an obvious cause – correct it and review If there is no improvement or you are unsure of diagnosis, REFER Does this need a biopsy? – why do I need a biopsy? – confirm the diagnosis, exclude dysplasia?, exclude malignancy?
33
What is erythroplakia
red patch or lesion
34
What is erythoplakia like
Atrophic lesion Localised/focal Well defined borders Velvety/red texture Can have a speckled appearance (Erythroleukoplakia) 'fiery red patch that cannot be characterised clinically or pathologically as any other definable lesion.’ Soft palate/buccal mucosa/floor of mouth are common sites Strong association with tobacco use
35
What can erythoplakia be assoc with
51% showed invasive carcinoma 40% carcinoma in situ 9% mild or moderate dysplasia 50% malignant transformation rate May have p53 mutation REFER URGENTLY to OMFS or Oral Medicine
36
What is Erythro-leukoplakia and why bad
Speckled red/white patches Heterogenous appearance Exists on a spectrum with red and white patches HIGHLY SUSPICIOUS for SCC or Severe Dy
37
What is the management of red patches
Thorough History and examination Exclude red flags Get photos Is there an obvious cause – correct it and review Red patches or red-speckled patches have HIGH malignant potential If the red patch can’t be attributed to another cause, a biopsy is needed for an accurate diagnosis
38
How can you categorise non-odontogenic pain
Nociceptive – Normal physiological response, pain that arises from actual or threatened damage to non-neural tissue and is due to the activation of nociceptors Neuropathic – Lesion or disease of the somatosensory nervous system – TN is a NEUROPATHIC PAIN Nociplastic pain – It results in increased sensitivity from the altered function of pain-related sensory pathways in the periphery and central nervous system (Triggered by non-nociceptive stimuli)
39
What is trigeminal neuralgia
A disorder characterized by recurrent unilateral brief electric shock-like pains, abrupt in onset and termination, limited to the distribution of one or more divisions of the trigeminal nerve and triggered by innocuous stimuli
40
What types of TN is there
classical secondary idiopathic
41
How may a pt describe TN
Stabbing, electric shock, scary, 10/10 pain, severe, will remember first episode
42
What could a SOCRATES of TN be like
Sight -Unilateral, Mandibular/Maxillary distribution – usually one branch(60%) infrequently two (35%) Onset -Sponatenous onset, sometimes triggers, but not always Character -Sharp/electric shock like/10/10/worst pain ever/severe Radiation -Spread along branch of TN nerve, may have a focused starting point Associated features Distress, suicidal ideation, Time -Random. Short lived up to two minutes, multiple times a day, MAY have constant less severe background pain Exacerbating/relieving -Exacerbating: Cold wind, washing face/shaving/brushing teeth -Relieving: not moving face, avoiding triggers, Severity - 10/10
43
Normal TN triggers
Eating Washing face Brushing teeth Eating Speaking Smiling Cold wind Temperature change Stress
44
What are red flags associated with TN
Sensory motor defects Deafness Loss of balance Optic neuritis History of cranio-facial malignancy Bilateral TN Systemic symptoms < 30 years of age
45
Trigeminal Neuralgia: Management in general dental practice
Obtain accurate diagnosis, exclude dental/TMD pathology Consider commencing Carbamazepine, liaise with GP for blood monitoring – If you are unsure if carbamazepine is safe to prescribe call Oral Medicine for advice Consider Local anaesthetic if the patient is in extreme pain URGENT Referral To Oral Medicine/OMFS for definitive advice
46
What is the prescription of carbamazepine we can do and what to be careful of
10 day regimne 1 100mg tablet x2 daily send 20 Care in the elderly as increases falls risk, in those operating heavy machinery/driving/childcare due to blurring of vision and dizziness
47
TN secondary care
MRI Scan All patients -Space occupying lesion -Multiple Sclerosis -Neurovascular conflict Medication Optimisation Use the lowest dose that controls symptoms -carbamazepine -oxcarbazepine -Lamotrigine -Baclofen -gabapentin -pregabalin in refractory cases Local anaesthetic in acute episodes
48
How does carbamazepine work
carbamazepine works by stabilising the electric signals in your nerves This stops the pain signals being sent to your brain
49
What nerosurgery approaches of TN is there
Microvascular decompression Neuro-ablative procedures e.g. balloon compression Stereotactic radiosurgery
50
What is oral dysaesthesia and what symptoms
persistent alteration to oral sensation, perceived to be abnormal and/or unpleasant in the absence of an identifiable local or systemic cause Prickling Burning Numb Tingling Shooting sensation
51
What red flags of oral dysaesthesia is there
Objective numbness -Permanently lost sensation Unilateral symptoms Dysphagia Odynophagia Weight loss Loss of balance/hearing change Unexplained motor or other sensory changes
52
GDP and oral dysaesthesia
Exclude dental or mucosal cause for symptoms Explain no worrying features, but acknowledge the patient’s symptoms are real, describe the provisional diagnosis. Refer to OM and simultaneously ask GP to consider blood investigations Consider saliva substitutes and difflam
53
What drugs are the worst offenders for dry mouth
Antimuscarinic (anticholinergic) -Amitriptyline: 26% reduction Diuretics -Bendroflumethiazide: 10% reduction Lithium -70% have a significant reduction
54
what saliva substitutes are there
Sprays -Glandosane -Saliva Orthana Lozenges/pastilles -Saliva Orthana (contains porcine mucin) -Salivix Salivary stimulants -Pilocarpine (Salagen) Oral Care Systems/Gels -Biotene Oralbalance -Bioextra Gel -Xerostom
55
Reasons for saliva glands lumps or swelling
Obstruction -Something is stopping the saliva from leaving the gland Sialadenitis -Inflammation of the salivary glands Sialosis -Bilateral painless swelling Neoplasm Trauma and fluid -Oedema and blood Solid deposits -Protein build up (Amyloidosis) Intra-gland lymph node swelling
56
What to do for obstructive sialadenitis
MEALTIME SYNDROME (pain and swelling in the salivary glands particularly during mealtimes) History -Pain history if needed -Ask if associated with eating/food -Coming and going or persistent -Swallowing problems -Bad taste or pus Clinical assessment -Extra-oral exam -Bimanual palpation of Floor of mouth -Express saliva from ducts Investigations -Lower occlusal x-ray +/- OPT to identify calcification – Primary care -Ultra-sound scan – Secondary care -Sialography – Secondary care
57
clinical features of acute viral sialadenitis
Painful parotid swelling Usually bilateral Sometimes can be a single gland No hyposalivation 10% have submandibular gland involvement Very rare to involve ONLY the submandibular gland Malaise, fever and feeling generally unwell, which likely precedes the parotid swelling Trismus Swelling will last approximately seven days
58
Diagnosis and management of acute viral sialadenitis
Diagnosis -Clinical grounds -Serum antibodies can be considered -Viral swab of saliva Management -THERE ARE NO SPECIFIC antivirals -Supportive therapy -Hydration -Analgesia -Pyrexia management -Isolation for 6-10 days may be advisable
59
Clinical features of acute bacterial sialadenitis
Most common in parotid glands (parotitis) Typically unilateral Painful swelling Overlying erythema Pus from duct Trismus Pyrexia Cervical Lymphadenopathy Often secondary to salivary gland obstruction
60
Diag and management of acute bacterial sialadenitis
Diagnosis -Clinical grounds -Pus swab for culture and sensitivities -Exclude pyrexia/sepsis Management -Antibiotics through GP or OMFS -First choice is flucloxacillin, erythromycin in penicillin-allergic patients -Airway management if needed -Manage causative factors when acute sialadenitis resolved
61
Red flags for neoplasms in salivary glands
Facial palsy Sensory loss Pain Difficulty swallowing Trismus Rapid growth