Flashcards in Oral Sedation and Anxiety Control Deck (39):
The dissociation constant has to match the pH of the compartment for the drug to be absorbed.
Some drugs need these to be broken down.
Bile salts or bacteria.
Why do anti-cholinergics delay gastric emptying?
Because the stomach is stimulated by the Vagus nerve, which is cholinergic.
These three things cause delayed gastric emptying.
Diabetes, Scleroderma, Amyloidosis
The fraction of the drug dose that gets into the systemic circulation.
T/F: You cannot titrate oral sedatives.
First pass metabolism of a drug occurs in what organ?
Diffusion from high to low concentration.
These molecules diffuse more readily.
Small, non-polar lipid soluble molecules
What is ion-pair transport?
Anions bind to Cations to form a neutral complex that can pass the cell membrane by passive diffusion.
-Reversibly associated with the drug
-Buffer wide fluctuations in free drug concentration
If the drug readily binds to these, they will stay in the body longer.
Obesity and drug distribution
Obese people with large lipid stores hold onto the drug longer.
Metabolism of a drug involves this.
Conversion from lipid to water soluble.
Where most agents get metabolized.
Phase I reactions in drug metabolism involve what?
Phase II reactions in drug metabolism
The drug is combined with glucuronic acid to form water soluble complexes.
Most drugs are eliminated through which organ?
What is this? :
Drug is conjugated with biliary salts, goes through the intestinal tract, and gets recycled and reabsorbed.
What kind of sedation is not recommended for kids under 12?
Types of sedation
May need to maintain the airway in this type of sedation.
Patients cannot be easily aroused during this type of sedation.
Stages of Anesthesia
Stage 1, 2, 3, 4
Stage 1 Anesthesia
Stage 2 Anesthesia
Stage 3 Anesthesia
Stage 4 Anesthesia
Minimally depressed level of consciousness.
Cognition and Coordination are modestly impaired.
Ventilatory and cardiovascular functions are un-impaired.
This type of sedation:
patients respond to verbal commands alone or accompanied by light tactile stimulation.
Drug induced loss of consciousness in which patients are not arousable even by painful stimulation.
Requires a device to maintain a patent airway.
CV function may be impaired.
If lower BP more than this %, can cause brain damage bc not enough pressure to pump blood to the brain.
Oxygenated Hb absorbs _____ light at ____ nm.
You regain full psychological and physical capacity in this stage of recovery.
You regain full psychomotor function and resume physical activity in this stage of recovery.
Used as discharge criteria.
Aldrete Scoring System