Oral surgery Flashcards
(177 cards)
3 effects of aspirin
Analgesic
(COX-1 & 2 inhibition, reduces prostaglandin synthesis)
Antipyretic
(prevents temperature raising effects of IL-1 - reduces elevated temperature in fever)
Anti-inflammatory
(reduced prostaglandin synthesis as prostaglandin is vasodilator which affects capillary permeability)
4 adverse effects of aspirin
GIT problems - ↑ gastric acid secretion, ↓ blood flow through gastric mucosa, ↓ mucin production & cytoprotective action
Hypersensitivity
Overdose - tinnitus, metabolic acidosis
Aspirin burns on mucosa
Groups to avoid/ caution prescribing aspirin to (14)
- Peptic ulceration
- Gastric pain
- Bleeding abnormalities
- Anticoagulant users
- Steroid users
- Renal/ hepatic impairment
- < 16 yrs
- Asthmatics
- Hypersensitivity to other NSAIDS
- Using other NSAIDS
- Elderly
- Pregnant women
- Nephrotoxicity
- G6PD-deficiency
4 absolute contraindications of prescribing aspirin
- Lactating women
- Children below 16 (Reye’s syndrome)
- Haemophilia
- Hypersensitivity to aspirin or other NSAIDS
Prescription of aspirin
300mg 2 tablets qid after food, 5 days
For odontogenic pain
Maximum adult dose of ibuprofen
2.4g
Groups to caution when prescribing ibuprofen (8)
- Active/ previous peptic ulceration
- Asthmatics
- Taking other NSAIDS
- NSAID hypersensitivity
- Pregnancy/ lactation
- Renal/ cardiac/ hepatic impairment
- Patients on long term systemic steroids
- Elderly
3 adverse effects of ibuprofen
- GI discomfort
- Hypersensitivity reactions
- Headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus… (see BNF)
For patients taking antihypertensive drugs, how many days should the regimen of ibuprofen be restricted to?
5 days or less
3 symptoms of ibuprofen overdose + management
Symptoms:
- nausea
- vomiting
- tinnitus
Management: Activated charcoal if more than 400 mg/kg ingested within the last hour
Prescription of paracetamol
500mg 2 tablets qid 5 days
For odontogenic pain
Mode of action of paracetamol
Indirect inhibition of COX pathway by blocking positive feedback action of hydroperoxides
3 groups to caution when prescribing paracetamol
- Hepatic impairment
- Renal impairment
- Alcohol dependance
4 (rare) side effects of paracetamol
- Rashes
- Blood disorders
- Hypotension
- Liver damage following overdose (less frequently kidney damage)
What is considered a therapeutic excess of paracetamol? (2)
More than 8g in 24 hours (recommended adult daily dose) and > 75 mg/kg
What amount/ level of paracetamol may cause severe hepatocellular necrosis?
150 mg/kg
Management of paracetamol overdose
Refer to A&E for assessment
Considerations for flap design
- Wide based
- No sharp angles
- Adequate side (size does not affect healing)
- Avoid dental papillae
1 advantage & 1 disadvantage of polyfilament sutures
Advantage
- Easy to handle
Disadvantage
- Prone to wicking, draws bacteria and can result in infection
3 advantages & 1 disadvantage of monofilament sutures
Advantages
- Passes easily through tissue
- Resistant to bacterial colonisation
- Causes less scarring
Disadvantage
- Slippery and difficult to handle
Advantages of ZOE as retrograde sealant for periradicular surgery (4)
- Cheap
- Easy to use
- Radiopaque
- Bacteriostatic
Disadvantages of ZOE as retrograde sealant for periradicular surgery (3)
- Sensitive to moisture
- May resorb
- Doesn’t promote cementogenesis
Advantages of MTA as retrograde sealant for periradicular surgery (3)
- Moisture resistant
- Promotes cementogenesis
- Very good seal
Disadvantages of MTA as retrograde sealant for periradicular surgery (3)
- Expensive
- Long setting time
- Difficult to use