ORGAN DONATION AND SCREENING

Question 1

Goals of pretransplant screening

Answer 1

1. To identify conditions which may disqualify either donor or recipient
2. To identify and treat active infection pretransplant
3. To define the risk of infection and determine strategies for preventing and mitigating posttransplant infection
4. To implement preventative interventions
5. To facilitate transplants from previously infected donors and recipients.

Question 2

Bacterial Infections
* All SOT candidates should be
evaluated for latent ___ and
___.

Answer 2

syphilis and TB

Question 3

A detailed social history is of
utmost importance

true or false

Answer 3

true

Question 4

There are two types of serologic tests for syphilis:

what are those

Answer 4

non treponemal tests
treponemal-specific tests.

Question 5

a type of serologic test for syphilis that detect antibodies against cardiolipin
and are not specific.

Answer 5

Non-treponemal tests

Question 6

a type of serologic test for syphilis that detect antibodies against specific
treponemal antigens.

Answer 6

Treponemal tests

Question 7

CDC specifically recommends the ____ because of its superior
specificity and sensitivity compared with the fluorescent
treponemal antibody absorption assay.

Answer 7

Treponema pallidum
particle agglutination (TP-PA) assay

Question 8

The two methods to assess cellular immune response for TB include
the__ and ___

Answer 8

in vivo tuberculin skin test (TST)
ex vivo interferon gamma release assays (IGRA).

Question 9

The TST elicits a ___ after
local intradermal application of purified protein derivative.

what type of hypersensitivty?

Answer 9

delayed–type hypersensitivity reaction

Question 10

IGRAs measure T cell release of _____
following stimulation with antigens present in M. tuberculosis.

Answer 10

interferon gamma (IFN-γ)

Question 11

Transplant recipients are at risk for several parasitic
infections, including ___ and ___.

Answer 11

toxoplasmosis and strongyloidiasis

Question 12

is an uncommon but
highly morbid infection after
transplantation

Answer 12

Toxoplasmosis

Question 13

Toxoplasmosis test involves detection of what specific antibody?

Answer 13

IgG

Question 14

is a devastating disease in
transplant recipients, with 50–70% mortality
in those with hyperinfection syndrome and
disseminated infection

Answer 14

Strongyloidiasis

Question 15

Strongyloides IgG is measured by ___

Answer 15

ELISA

Question 16

• IgG measured by ELISA has a high
  sensitivity and specificity for diagnosing
  ___.

Answer 16

strongyloidiasis

Question 17

Post-transplant histoplasmosis is rare,
with an estimated incidence ____, even in
endemic areas.

Answer 17

<1%

Question 18

Screening is not recommended for
serological evidence of prior infection with
Histoplasma capsulatum in asymptomatic
transplant candidates.

true or false

Answer 18

true

Question 19

A proper pre-transplant evaluation also includes
screening for many viral infections, including ___

Answer 19

HIV,
hepatitis B virus (HBV) and hepatitis C HCV.

Question 20

Is screening for HIV is required in pre
transplant evaluations.

Answer 20

yes

Question 21

The _ is responsible for
coordination of the evaluation and preparation of
patients for organ transplantation and long-term
management of patients after transplant.

Answer 21

Transplant Coordinator