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Organic Chemistry 5.0 - Pharmaceutical Chemistry Flashcards

(13 cards)

1
Q

What are drugs?

A

substances which alter the biochemical processes in the body

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2
Q

Drugs that have biochemical effects are used in ___.

A

medicines

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3
Q

What do medicines usually contain?

A

a drug, plus other ingredients such as filler to add bulk or sweeteners to improve taste

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4
Q

Drugs generally work by binding to specific ___ molecules, such as ___ ___, or specific ___ within a cell.

A

protein, surface receptor, enzymes

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5
Q

Which two things can drugs act on?

A

receptors
enzymes

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6
Q

Drugs which act on receptors can be classified as ___ or ___.

A

antagonists or agonists

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7
Q

What is an antagonist?
What is an agonist?

A

a substance which binds to a receptor and so blocks the natural response from occurring.
a substance which binds to a receptor and mimics a natural molecule, by producing a similar response (to the natural compound)

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8
Q

Many drugs are enzyme ___, which bind to the ___ ___ of the enzyme, preventing…

A

inhibitors, active site, the reaction which is usually catalysed there

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9
Q

The shape and size of a drug allows it to interact with… or…

A

an enzyme’s active site, or a receptor’s binding site

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10
Q

What are the types of interaction that occur between a drug and an enzyme’s active site/receptor’s binding site?

A

Van Der Waal’s forces and/or ionic bonds

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11
Q

This structural fragment of a drug molecule that allows it to interact with… or… consists of different ___ ___ correctly oriented with respect to each other.

A

enzyme active sites, receptor binding sites, functional groups

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12
Q

What is a structural fragment in a drug molecule?

A

a bunch of different functional groups correctly oriented with respect to each other.

Called pharmacophore- not in spec, dont use

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13
Q

By comparing the structures of drugs that have ___ effects on the body, the ___ fragment that is involved in the drug’s ___ can be identified.

A

similar, structural, function

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