Organic Medicinals Mini Quiz Flashcards by Janina Joya

Which of the following statements concerning adrenergic agonists are TRUE?
I. catecholamines are activated by the methylation of the methyl hydroxyl group.
II. the phenylethylamine and imidazoline chain is essential for indirect-acting activity.
III. N-substituent alter drug activity.

A. I only
B. III only
C. I and II
D. II and III

B. III only

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Barbiturates containing phenyl and ethyl substituents at carbon 5 are usually:
A. short acting
B. intermediate acting
C. long acting
D. ultra-short acting

C. long acting

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Which of the following is a saturated triketopyrimidine?
A. benzodiazepines
C. tricyclic antidepressant
B. barbiturates
D. butyrophenones

B. barbiturates

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All of the following anesthetics are gases at room temperature, EXCEPT:
A. nitrous oxide
B. halothane
C. ethylene
D. cyclopropane

B. halothane

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Local anesthetic that is derivative of benzoic acid is:
A. Lidocaine
C. Dibucaine
B. Procaine
D. Bupivacaine

B. Procaine

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Xanthine derivatives are indicated in/for:
A. asthma
B. analgesic
C. antipyretic
D. epilepsy

A. asthma

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Which of the following is not a phenothiazine derivative?
A. Nortriptyline
B. Chlorpromazine
C. Thioridazine
D. Fluphenazine

A. Nortriptyline

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Functional group of Bupivacaine:
A. amine
B. ester
C. alcohol
D. ketone

A. amine

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The onset and duration of barbiturate action is mainly a function of its:
A. lipid solubility
B. renal excretion
C. plasma binding
D. method of administration

A. lipid solubility

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Dibenzoazepine derivatives having a methyl or dimethyl aminopropyl group attached to the ring nitrogen have:
A. local anesthetic activity
C. opioid antagonistic property
B. antidepressant property
D. general anesthetic property

B. antidepressant property

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Which of the following compounds, because of its chemical relationship to Fluphenazine would most likely cause similar side effects?
A. Thioridazine
C. Chlorpromazine
B. Prochlorperazine
D. Triflupromazine

D. Triflupromazine

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Which of the following agents has/have a beta-phenylethylamine structure with the phenyl moiety containing ortho-dihydroxy substitution?
I. Epinephrine
II. Ephedrine
III. Dopamine

A. I only
B. II only
C. I and III
D. II and III
E. I, II and III

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Which of the following agents has/have a beta-phenylethylamine structure with the phenyl moiety containing ortho-dihydroxy substitution?
I. Epinephrine
II. Ephedrine
III. Dopamine

A. I only
B. II only
C. I and III
D. II and III
E. I, II and III

C. I and III

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What is the common use of the drug in the structure given below?
O
II
HN NH
I I
//\ /
O /\ O
R1 R2

A. Anticonvulsant
B. Sedative-hypnotic
C. Intravenous anesthetics
D. Antipsychotic
E. Antidepressant

B. Sedative-hypnotic

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Which of the following metabolites of methoxyflurane is primarily responsible for the neurotoxicity associated with this inhalation anesthetic?

A. Fluoride
B. Oxalic acid
C. Dichloroacetic acid
D. Bromide

A. Fluoride

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Agents possessing the structure given below are most used for what condition?
S
/\/ \/\
I I I I
\/\ /\/\
N R1
I
\
I R
\ /
N
I
R

A. Seizure disorder
B. Bacterial infection
D. Psychosis
E. Bipolar disorder
C. Anticholinesterase

D. Psychosis

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Which of the following choices correctly illustrates the general structure of local anesthetics?
A. lipophilic center–ester/amide- bridge– hydrophilic center
B. lipophilic center– bridge– ester/amide– hydrophilic center
C. bridge– lipophilic center–hydrophilic center- ester/amide
D. hydrophilic center– bridge– ester/amide– lipophilic center

A. lipophilic center–ester/amide- bridge– hydrophilic center

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Which of the following neuromuscular blockers possesses a steroid nucleus?
A. Atracurium
C. Tubocurarine
B. Pancuronium
D. Doxacurium

B. Pancuronium

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Identify the specific oxidation reaction involved in the reaction given below:

      O
      II    S -> S

A. S-oxidation
B. N-oxidation
C. S-dealkylation
D. O-dealkylation

A. S-oxidation

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CYP450 is found in very high concentrations in the liver and to a lesser extent in the intestinal mucosa, lungs, and kidneys
A. True
B. False

A. True

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Aldehyde dehydrogenase is a general name for a group of enzymes expressed in the mitochondria and the cytosol responsible for oxidizing an aldehyde to a carboxylic acid.
A. True
B. False

A. True

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What is the co-factor involved in producing the metabolite Morphine-6-O-Glucuronide? (Refer to the reaction below)

A. UDP-GA
B. PAPS
C. SAM
D. Acetyl-CoA

A. UDP-GA

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What is the co-factor involved in producing the metabolite Morphine-3-Sulfate? (Refer to the reaction below)
A. UDP-GA
B. PAPS
C. SAM
D. Acetyl-CoA

B. PAPS

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Identify the type of reaction involved:
O
/\
= -> —
A. Methylation
B. Glucuronidation
C. Hydrolysis
D. Oxidation

D. Oxidation

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Identify the type of drug metabolism based on the reaction below: O /\ = -> — A. Phase 1 B. Phase 2

A. Phase 1

Identify the type of reaction involved: O HO HO /\ -> \ / — — A. Methylation B. Glucuronidation C. Hydrolysis D. Oxidation

C. Hydrolysis

Which of the following mechanism may convert acetylcholine to acetic acid? A. oxidation B. reduction C. hydrolysis D. two of the choices

C. Hydrolysis

Which is the most performed conjugation reaction? A. glucuronidation B. glycine conjugation C. sulfation D. hydrolysis

A. Glucuronidation

Glutathione is a tripeptide consisting of Υ-glutamate, cysteine, and glycine. This compound is involved in ____ metabolism. A. Phase 1 B.Phase2 C. both A and B

B.Phase2

Methylation is significant in the biosynthesis of nucleic acids, proteins, phospholipids, neurotransmitters, and other amines. This biochemical pathway is involved in __________ metabolism. A. Phase 1 B.Phase2 C. both A and B

B.Phase2

Qualitative differences result from a genetic deficiency of a particular enzyme or a difference in particular endogenous substrate; occur primarily with __________ reactions. A. Phase I B.PhaseII C. both A and B

B.PhaseII

The deficiency of the following minerals decrease drug-metabolizing capacity except: A. Iron B. Mg C. Ca D. Zn

A. Iron

The following reactions are involved in Phase I metabolic biotransformation, EXCEPT: A. oxidation B. reduction C. conjugation D. hydrolytic reaction

C. conjugation

Enzyme responsible for most oxidative formations. A. Cytochrome P420 C. Cytochrome D450 B. Cytochrome P450 D. all the above

B. Cytochrome P450

Which of the following mammalian families are required in the metabolism of endogenous substances? A. CYP1 B.CYP2 C. CYP10 D. CYP11

D. CYP11

Ascorbic acid, an acid lactone, undergoes oxidation and excreted via the ___________. A. liver B. kidney C. both A and B D. none of the choices

B. kidney

Bronchodilation effects of Salbutamol and other drugs for the treatment of asthma are attributed to the presence of: A. catechol ring C. quaternary ammonium comp B. phenylethylamine D. imidazoline

B. phenylethylamine

A catechol ring with a modification of the substituent on the secondary amine group, most commonly to substituent isopropyl, leads to ____ receptor. A. Non-selective β C. selective β2 B. Selective β1 D. Non-selective α E. Selective α1

A. Non-selective β

Which of the following enzymes is needed in the conversion of epinephrine to norepinephrine? A. N-Acetyltransferase C. Glucuronosyltransferase E. Sulfotransferase B. Methyltransferase D. Glutathione-S-transferase

B. Methyltransferase

Which of the following metabolic reactions requires enzymes and co-factors? A. Oxidation C. Hydrolysis B. Methylation D. Reduction

B. Methylation

Which of the following is a non-selective beta blocker? A. Metoprolol C. Atenolol B. Propranolol D. Acebutolol

B. Propranolol

A Non-selective alpha adrenergic agonist with imidazoline nucleus are commonly indicated for: A. hypertension C. bronchodilator B. vasodilator D. decongestant

A. hypertension

As the size of the alkyl group decreases, the pharmacologic activity of adrenergic amines will predominantly be: A. alpha C. alpha and beta B. beta D. no change

A. alpha

Methylbenzene is also known as: A. anisole B. toluene C. aniline D. catechol

B. toluene

Epinephrine is also known as: A. alpha tocopherol B. adrenalin C. emerine D. levarterenol

B. adrenalin

The principal hydrolytic degradation product of Aspirin is: A. Methyl salicylate C. Salicylic acid B. Acetyl chloride D. Salicylamide

C. Salicylic acid

Hydroxybenzoic acid is: A. acetic acid B. salicylic acid C. oxalic acid D. citric acid

B. salicylic acid

1,3-dimethylxanthine is: A. caffeine B. theobromine C. theophylline D. aminophylline

C. theophylline

Amide type local anesthetics are: A. short acting B. intermediate acting C. long acting D. none of the choices

C. long acting

Antibacterial potencies of primary alcohol increases with molecular weight up to ____ only: A. C 3 C. C 6 B. C 4 D.C8

D.C8

The simplest ketone is: A. methadone B. ethenone C. propanone D. butanone

C. propanone

The number of carbon atoms separating the amino from phenyl ring that will produce maximal sympathomimetic activity is: A. 1 B.2 C.3 D.4 E.5

B.2

What is the most potent effect of trimethyl substitutions in positions 1, 3, and 7 of the xanthine molecules? A. Diuresis B. Coronary vasodilation C. CNS stimulation D. Skeletal muscle relaxation

C. CNS stimulation

This drug is also known by the chemical name, (+)-N, alpha-dimethylphenylamine A. Amphetamine C. Ephedrine B. Methamphetamine D. Phentermine

B. Methamphetamine

Which portion of the general structure of the local anesthetics is important in the ability of the drug to penetrate through the cell membrane of the axon? A. Lipophilic center C. Amide group B. Ester group D. Hydrophilic center

A. Lipophilic center

Which portion of the general structure of the local anesthetics is responsible for binding to the sodium channels? A. Lipophilic center C. Hydrophilic center B. Ester group D. Bridge alkyl group

C. Hydrophilic center

A natural acetylcholinesterase inhibitor used as antidote for atropine overdose. A. physostigmine C. pyridostigmine B. neostigmine D. none of the choices

A. physostigmine

Which of the following group is present in a parasympathomimetic drug? A. trimethylammonium group B. ethylester C. phenylethylamine D. catecholamine

A. trimethylammonium group

The following drug has the imidazoline nucleus except: A. Xylometazoline C. Naphazoline B. Oxymetazoline D. phenylephrine

B. Oxymetazoline

A synthetic acetylcholinesterase inhibitor with benzanaminium parent compound used as antidote for tubocurarine poisoning. A. physostigmine C. pyridostigmine B. neostigmine D. none of the choice

B. neostigmine

Organic Medicinals Mini Quiz Flashcards

(60 cards)