Organic Synthesis Flashcards by Archie Hutchinson

Q

Alkene to Alkane

A

H2, Ni catalyst, 150C

electrophilic addiction

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Q

Alkene to Dihaloalkane

A

Br2, RTP

electrophilic addition

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Q

Alkene to Haloalkane

A

HBr, RTP

electrophilic addition

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Q

Alkane to Haloalkane

A

Br2, uv light

Free radical substitution

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Q

Alkene to Alcohol

A

c.H3PO4, Steam, Heat

electrophilic addition

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Q

Alcohol to Alkene

A

c.H3PO4, Heat

elimination

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Q

Haloalkane to Alcohol

A

NaOH, reflux

nucleophilic substitution

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Q

Alcohol to Haloalkane

A

KBr, ethanolic, c.H2SO4

nucleophilic substitution

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Q

Haloalkane to Nitrile

A

NaCN, ethanolic, reflux

nucleophilic substitution

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Q

Haloalkane to Amine

A

NH3, ehtanolic

nucleophilic substitution

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Q

Nitrile to Amine

A

H2, Ni catalyst

reduction

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Q

Amine to Amide

A

Acyl chloride

nucleophilic substitution

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Q

Acyl chloride to Amide

A

1’ or 2’ Amine or NH3

nucleophilic substitution

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Q

2’ Alcohol to Ketone

A

K2Cr2O7, H2SO4, reflux

Oxidation

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Q

1’ Alcohol to Carboxylic acid

A

K2Cr2O7, H2SO4, reflux

Oxidation

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Q

1’ Alcohol to Aldehyde

Study These Flashcards

A

K2Cr2O7, H2SO4, distil

Oxidation

Q

Aldehyde to Carboxylic Acid

Study These Flashcards

A

K2Cr2O7, H2SO4, reflux

Oxidation

Q

Aldehyde to Hydroxynitrile

Study These Flashcards

A

NaCN, H+

nucleophilic addition

Q

Ketone to Hydroxynitrile

Study These Flashcards

A

NaCN, H+

nucleophilic addition

Q

Ketone to 2’ Alcohol

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A

NaBH4, warm, H+

reduction, nucleophilic addition

Q

Aldehyde to 1’ Alcohol

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A

NaBH4, warm, H+

reduction, nucleophilic addition

Q

Carboxylic Acid to 1’ Alcohol

Study These Flashcards

A

NaBH4, warm, H+

reduction, nucleophilic addition

Q

Alcohol to Ester

Study These Flashcards

A

Carboxylic acid, c.H2SO4, warm

Esterification

Q

Carboxylic acid to Ester

Study These Flashcards

A

Alcohol, c.H2SO4, warm

Esterification

Ester to Alcohol and Carboxylic acid

HCl, heat Acid Hydrolysis

Ester to Alcohol and Carboxylate

NaOH, heat Alkaline Hydrolysis

Carboxylic Acid to Acyl Chloride

SOCl2 (Thionyl Chloride)

Acyl Chloride to Carboxylic Acid

H20

Nitrile to Carboxylic Acid

H+, acid hydrolysis

Acid Anhydride to Ester

alcohol, H+ esterification

Benzene to Bromobenzene

Br2, FeBr3 (halogen carrier) electrophilic substitution

Benzene to Methylbenzene

CH3Cl, AlCl3 (halogen carrier) Friedel-Crafts reaction

Benzene to Nitrobenzene

c.HNO3 and c.H2SO4 electrophilic substitution

Nitrobenzene to Phenyl amine

c.HCl, Sn catalyst, reflux

Phenol to 2,4,6-tribromophenol

3Br2, RTP electrophilic substitution

Phenol to Nitrophenol

dilute HNO3, RTP electrophilic substitution

Phenol to Sodium Phenoxide

NaOH neutralisation