Oro-Mucosal administration Flashcards
name the three types of lining
- Masticatory mucosa
- lining mucosa
- specialised mucosa
is masticatory mucosa keratinised?
-yes
is the lining mucosa keratinised?
- no
- drug absorption targets lining mucosa
what is the main source of fluid in the mouth?
-saliva
what are the three main glands that produces saliva
- sublingual
- submandibular
- parotid
what does the saliva/mouth contain
- water
- glycoproteins
- enzymes
- natural antimicrobials
what are the three different types of lozenges
- hard
- soft
- chewable
what are the products for ulcers
-gels, sprays, mouthwash, soft lozenges
what can dry mouth be caused by?
- diuretics
- cancer - chemo
- anticholinergic drugs
- dehydration, nerve damage
- stress
- smoking
- breathing through the mouth
where is the masticatory mucosa found?
-gums and hard palate
where is the lining mucosa found?
-soft palate, cheeks, lips and sublingual area
where is the specialised mucosa found?
- tongue and taste buds
what are the three important parameters?
- buccal pH 6.2-7.4
- log P
- molecular weight
what are the two different types of drug transport
-transcellular and paracellular
what is transcellular transport
- drug released from dosage form
- cross cell membrane
- comes out other side
- gains access to blood circulation
