Osteoarthritis Flashcards

(59 cards)

1
Q

describe the healing potential of articular cartilage

A

poor

unable to regenerate if damage

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2
Q

what cartilage covers the bones in synovial joints?

A

hyaline cartilage

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3
Q

what is hyaline cartilage made of?

A

water
collagen
proteoglycans
chondrocytes

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4
Q

what is primary osteoarthritis?

A

osteoarthritis when no cause is identified

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5
Q

what is involved in the conservative management of osteoarthritis?

A

NSAIDs
weight loss if needed
physiotherapy
steroid injections

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6
Q

how many steroid injections can be given for OA?

A

up to three per year

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7
Q

what is the risk of steroid injections in OA?

A

can cause further damage and accelerate the OA

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8
Q

what is TKR?

A

total knee replacement

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9
Q

when should TKR be considered for knee osteoarthritis?

A

moderate OA on X-ray

severe pain, not controlled conservatively

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10
Q

what characterises OA?

A

cartilage loss and accompanying periarticular change

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11
Q

what disease is often called “wear and tear” of the joints?

A

osteoarthritis

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12
Q

what joints can be affected by OA?

A

any synovial joint

most common = knees, hips and hands

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13
Q

what are the three main pathological changes in OA?

A

localised loss of hyaline cartilage

remodelling of adjacent bone

new bone formation at joints

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14
Q

what are the two main types of OA?

A

localised

generalised

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15
Q

what is localised OA?

A

osteoarthritis affecting one joint area

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16
Q

what is generalised OA?

A

OA at either the spinal/hand joints and at least two other joint regions

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17
Q

what two characteristic features can be seen in OA of the hand?

A

heberden’s nodes

bouchard’s nodes

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18
Q

where are heberden’s nodes found?

A

DIP joints

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19
Q

where are bouchard’s nodes found?

A

PIP joints

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20
Q

what is the classical clinical presentation of OA?

A

pain
morning stiffness <30 mins
instability

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21
Q

describe the pain in OA

A

gets worse with joint use

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22
Q

name five features found on examination of OA

A
joint line tenderness
crepitus 
bony swelling 
deformity 
limitation of motion
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23
Q

how is a diagnosis of OA made?

A

clinical suspicion

x-rays

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24
Q

what is seen on x-ray of OA?

A

Loss of joint space
Osteophytes
Sclerosis
Subchondral cysts

25
what are the two surgical options for OA?
joint replacement | arthroscopic surgeries to remove loose bodies
26
what is deposited in the joints in gout?
monosodium urate crystals
27
what is deposited in the joints in pseudogout?
calcium pyrophosphate crystals
28
what is deposited in the joints in hydroxyapatite?
calcium phosphate
29
which sex is more commonly affected by gout?
men
30
what particular group of women is gout rare in and why?
before the menopause oestrogen is protective
31
what two main things can cause hyperuricaemia?
increased urate production | reduced urate excretion
32
name four things that can increase urate production
enzyme defects psoriasis alcohol high dietary purine intake
33
name four things that can reduce urate excretion
chronic renal disease volume depletion hypothyroidism diuretics
34
describe the pattern of joint involvement in acute gout
usually a monoarthropathy
35
what are some common affected sites in acute gout?
first MTPJ ankle knee
36
what can uric acid levels be like in an acute attack of gout?
normal
37
what is chronic gout often associated with?
diuretic use
38
what are uric acid levels like in chronic gout?
high
39
what skin feature is present in chronic gout?
gouty tophi
40
what investigations are done for gout (4)?
serum uric acid inflammatory markers microscopy of synovial fluid x-rays
41
what will inflammatory markers be like in gout?
raised
42
what three drugs are given for acute gout?
NSAIDs colchicine steroids
43
what are five indications for prophylactic therapy of gout?
``` two or more attacks in a year signs of chronic gout renal impairment heart failure - on diuretics chemotherapy with gout ```
44
what is another name for pseudogout?
calcium pyrophosphate deposition disease (CPDD)
45
in what group is pseudogout more common?
the elderly
46
what is affected by pseudogout?
fibrocartilage
47
name three joints commonly affected by pseudogout?
knees wrists ankles
48
describe the appearance of calcium pyrophosphate crystals
envelope shaped | mildly positive birefringent
49
what happens to inflammatory markers in pseudogout?
raised
50
how is pseudogout managed?
NSAIDs colchicine steroids hydration
51
what group is most commonly affected by hydroxyapatite?
females aged 50-60
52
how is hydroxyapatite managed?
NSAIDs steroid injections physio arthroplasty
53
what is soft tissue rheumatism?
a general term to describe pain caused by inflammation or damage to tissues near a joint
54
what is the pain like in soft tissue rheumatism?
confined to one specific site
55
what is the most common area for soft tissue rheumatism?
the shoulder
56
who is more commonly affected by joint hypermobility syndrome?
females
57
what are some rare causes of joint hypermobility syndrome?
marfan's | ehler's danlos
58
when does joint hypermobility syndrome often present?
childhood | the third decade
59
how is joint hypermobility syndrome diagnosed?
the modified beighton score considered if patients have >4 out of 9