Osteoarthritis - Told Flashcards
(50 cards)
ostearthritis
not inflammation
most common arthropathy
osteoarthritis
enzyme degradation
osteoarthritis
multi-factorial etiology
nodal osteoarthritis
genetic
secondary OA
due to disorders damaging joint surface
progressive deterioration and loss of articular cartilage - leading to loss of normal joint structure and function
osteoarthritis
mechanisms of path in OA
1 - damage to normal articular cartilage - physical forces - macro and microtrauma
- chrondrocytes react - release degradative enzymes
- inadequate repair
2 - fundamental defective cartilage fails under normal loading - type II collage gene defect - ochronosis
ochronosis
type II collagen gene defect
-cannot handle normal loading
get osteoarthritis
pigmented and defective cartilage
ochronotic cartilage
sclerosis
subchondral bone thickening
-in osteoarthritis
risk fx for osteoarthritis
age obesity genetics gender menopause - possible hormone issues
common cause of back pain
osteoarthritis
DIP osteoarthritis
heberdens
PIP osteoarthritis
bouchards
1st CMC joint
base of thumb
compartments of knee
medial, lateral, patellar/femoral
pain in osteoarthritis
cartilage - no pain
but get synovitis capsule/ligament stretching trabecular microfractures muscle spasm intraosseous HTN
stiffness at rest
with RA
acute flares of pain
crystal disease
systemic sx of OA
no
joint pain with movement, slow onset, limited motion and decreased function
osteoarthritis
cool effusion
in osteoarthritis
clear fluid - on aspiration
class I
class I synovial fluid
non-inflammatory clear high viscosity form mucin clot low WBC count culture negative
ESR and RF in OA
negative
