Osteomyelitis, osteonecrosis, osteoradionecrosis Flashcards

1
Q

what is osteomyelitis?

A

Inflammation of bone, almost always secondary to infection

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2
Q

What are the ways in which you can get osteomyelitis? (3)

A
  1. Through the bloodstream
  2. Extension from an adjacent site (eg: big abscess that erodes in the jaw)
  3. Direct implantation
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3
Q

How do children tend to get osteomyelitis?

A

Through the bloodstream

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4
Q

How do adults tend to get osteomyelitis?

A

Fractures, surgical infections or diabetic foot

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5
Q

What bacterium is the common cause of osteomyelitis?

A

Staph Aureus

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6
Q

What is the clinical presentation of osteomyelitis?

A

Fever, localised bone pain, overlying tenderness

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7
Q

What are the risk factors for osteomyelitis?

A

Infection, peri-implantitis, infected cyst, infected tumour, surgical wound, fibrous dysplasia, osteoporosis, osteopetrosis, pagets disease, immuno-compromised pts (DB, HIV)

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8
Q

Why is the mandible more susceptible to osteomyelitis?

A

blood supply is less oxygenated AND dense overlying cortical bone prevents penetration of periosteal blood vessels

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9
Q

What is the tx for osteomyelitis?

A

Empirical antibiotics (penicillin) as broad spectrum
Surgery to remove sequestrum (allows better blood supply) + antibiotics

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10
Q

What appearance will chronic osteomyelitis give on an x-ray

A

moth eaten/sequestrum of bone

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11
Q

what is the difference between osteomyelitis and alveolar osteitis? (3)

A

osteomyelitis spreads through bone, AO is localised
osteomyelitis is NOT self-limiting, AO will get better is untreated
osteomyelitis is more chronic

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12
Q

After how long should a socket have healed?

A

8 weeks

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13
Q

What is osteoradionecrosis?

A

bone necrosis in previously irradiated tissue lasting for at least 6 months without any tendency to heal

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14
Q

What is endarteritis obliterans?

A

ends of the vessels are obliterated which reduces the blood supply - lack of oxygen to the area = death of cells and reduced blood supply so bone cant repair itself + trauma/infection = necrotic bone

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15
Q

what are the clinical features of osteoradionecrosis?

A

severe pain
non-healing exposed bone

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16
Q

which individuals might be taking bisphosphonates

A

pagets disease
osteopetrosis
osteoporosis
metastasizing solid cancers
multiple myeloma

17
Q

What is MRONJ?

A

exposed bone which has persisted for more than 8 weeks in patients with a history of treatment on the above medication and where there has been NO history of radiation therapy

18
Q

What are some examples of bisphosphonates?

A

Alendronic acid
Zolendronic acid
Risedronate sodium

19
Q

What are examples of biologics?

A

Denosumab, sunitinib

20
Q

Who is at increased risk of BRONJ?

A

immunosuppression (steroids/methotrexate)
immunocompromised (DM/HIV)
other med (chemotherapy/anti-angiogencs)

21
Q

What is osteonecrosis?

A

infarction of the bone marrow

22
Q

What is the likely cause of osteonecrosis?

A

alcohol, steroids, fractures BUT VASCULAR INSUFFICIENCY (damage to the blood vessels which leads to ischemia and necrosis of the bone)

23
Q

Is osteonecrosis septic?

A

NO it is ASEPTIC (there is no infection)

24
Q

what is the presentation of osteonecrosis?

A

joint pain
MRI will sho bone marrow oedema

25
Q

what is the management of osteonecrosis?

A

surgical decompression, grafts, joint replacement