Osteoporosis

Question 1

MoA of Bisophonates

Answer 1

inhibition of osteoclasts

Question 2

Denosumab MoA

Answer 2

Inhibits the receptor activator of nuclear factor-kappa B ligand (RANKL)

Question 3

What are the management for low, intermediate and high risk FRAX score?

Answer 3

Low risk - give reassurance and lifestyle advice, reassess within the next five years.
Intermediate risk - perform a DEXA scan to guide management.
High risk - start bisphosphonate therapy; no need to perform a DEXA scan first.

Question 4

What is a DEXA scan used for and what T score indicates osteoporosis?

Answer 4

A DEXA scan is used to measure bone mineral density. A T score of <-2.5 is diagnostic for osteoporosis

Question 5

Bisophonates instructions

Answer 5

To take the medicine on an empty stomach first thing in the morning before breakfast and remain upright for at least 30 minutes after taking it