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Flashcards in Osteoporosis Drugs Deck (8)
1

Which drugs have a MOA on osteoclasts?

-Bisphosphonates
-Denosumab
-Calcitonin
-SERM
-Estrogen

2

Which drug has an MOA on osteoblasts?

Teriparatide

3

Bisphosphonates

-First line therapy
-Anti-resorptive, binds to bone, inhibits osteoclast activity and promotes osteoclast death

4

Adverse events of Bisphosphoates

-GI: difficulty swallowing, inflammation of esophagus and gastric ulcers
-Inc in creatinine
-Flu like illness

Long term:
-Atypical fracture of femur
-Osteononecrosis of the jaw

5

Denosumab

Can be first line (2010)
Human monoclonal antibody
Antiresorptive, inhibits osteoclast formation, inhibits RANKL (which activates osteoclasts and promotes their formation)
-->LOOKS LIKE OPG
NOT renally excreted

6

Adverse effects of denosumab

Hypocalcemia, infectious and skin reactions

7

Teriparatide

-Moderate to severe second line therapy
-Anabolic agent, inc osteoblast activity
-Can follow with antiresorptive agent
-PTH analog
-Balance...in first two years, bone formation>bone destruction

8

Teriparatide: adverse events

-Nausea, headaches, leg cramps, hypercalcemia, orthostatic hypotensions, palpitations
-Osteosarcoma
-AVOID in paget's dis, high alk phos, hypercalcemia, h/o skeletal malignancy, radiation or mets