Other Abnormalities of Arginine Vasopressin Metabolism and Action

Question 1

The initial manifestation of systemic dehydration is often..?
Pertaining to sodium and osmolarity ..?

Answer 1

hypernatremia and hyperosmolality,

Question 2

What is the major stimulus for vasopressin release in Systemic Dehydration ..?

Answer 2

The initial manifestation of systemic dehydration is often hypernatremia and hyperosmolality, which subsequently lead to the activation of vasopressin secretion and a decrease in water excretion.

As dehydration progresses, hypovolemia and/or hypotension become a major stimulus for vasopressin release, further decreasing free water clearance.