Other Antidepressants Flashcards
Name the other antidepressants
Agomelatine (Domion, Valdoxan)
Mianserin (Lumin)
Mirtazapine (Avanza, Axit, Mirtanza)
Moclobemide (Amira, Clobemix)
Reboxetine (Edronax)
Vortioextine (Brintellix)
Agomelatine (Domion, Valdoxan) MOA
Melatonin receptor 1 and 2 agonist and serotonin 2C receptor antagonist
Agomelatine (Domion, Valdoxan) Adverse Effects
Dizziness
Abdominal Pain
Nausea
Diarrhoea
Mianserin (Lumin) MOA
Tetracyclic antidepressant; blocks presynaptic alpha 2 adrenergic receptors and therefore increases central noradrenergic neurotransmission
It also antagonises some postsynaptic serotonin receptors.
Mianserin (Lumin) Adverse Effects
Sedation
Dry Mouth
Dizziness
Vertigo
Mirtazapine (Avanza, Axit, Mirtanza) MOA
Tetracyclic antidepressant; acts by postsynaptic blockade of serotonin 5HT2 and 5HT3 receptors and presynaptic blockade of central alpha2-adrenergic inhibitory autoreceptors.
It is also a potent H1 antagonist which accounts for its sedative effects.
Mirtazapine (Avanza, Axit, Mirtanza) Adverse Effects
Increased appetite
Weight gain
Sedation
Weakness
Peripheral oedema
Moclobemide (Amira, Clobemix) MOA
Moclobemide competitively and reversibly inhibits monoamine oxidase; it is relatively selective for type A.
Synaptic concentrations of serotonin, noradrenaline and dopamine are increased.
Moclobemide (Amira, Clobemix) Adverse effects
Nausea
Constipation
Dry mouth
Insomnia
Dizziness
Reboxetine (Edronax) MOA
Inhibits noradrenaline reuptake and weakly inhibits serotonin reuptake.
Reboxetine (Edronax) Adverse effects
Urinary retention
Urinary frequency (males)
Dry mouth
Dizziness
Vortioextine (Brintellix) MOA
Inhibits the serotonin transporter, and acts as an antagonist at some 5HT receptor subtypes and as an agonist at others.
It is thought to increase serotonin activity in the CNS.
Vortioextine (Brintellix) Adverse effects
Nausea
Vomiting
Constipation
Dry mouth
Itch
