Other Disorders of Hemostasis Flashcards Preview

Ch. 04 Hemostasis + Related > Other Disorders of Hemostasis > Flashcards

Flashcards in Other Disorders of Hemostasis Deck (13)
Loading flashcards...
1
Q

Mechanism of heparin-induced thrombocytopenia

A

heparin complexes with PF4 (platelet factor 4)
IgG is produced against this complex
feared complication: thrombosis when remnants thrown out

2
Q

Feared complication of heparin-induced thrombocytopenia

A

peripheral thrombosis

from remnants being thrown into circulation

3
Q

What OB complication results in DIC

A

tissue thromboplasin into circulation
from amniotic fluid
activates coagulation cascade

4
Q

Animal whose bite can precipitate DIC

A

rattlesnake bite

5
Q

How to tell the difference between DIC and disorders of fibrinolysis in labs

A

DIC has + D-dimers
disorders of fibrinolysis have negative D-dimers
*because in disorders of fibrinolysis, the clot never gets to form so there are no D-dimers

6
Q

Tx of DIC

A

underlying cause

blood products + cryoprecipitate

7
Q

What normally inactivates plasmin

A

α2-antiplasmin

produced by liver

8
Q

How are clots normally resolved

A

plasminogen –> plasmin

plasmin breaks down fibrin into D-dimers

9
Q

Labs in disorders of fibrinolysis

A

negative D-dimers
positive fibrinogen split products
*note fibrinogen and not fibrin, which would be D-dimers

10
Q

Plasmin actions

A
cleaves fibrin
cleaves fibrinogen
destroys factors
blocks platelet aggregation
*breaks clots up and doesn't allow clots to be formed
11
Q

2 common causes of disorders of fibrinolysis

A

urokinase release during radical prostatectomy

cirrhosis: decreased α2-antiplasmin release

12
Q

Tx of disorders of fibrinolysis

A

aminocaproic acid
blocks activation of plasminogen
“caps” the bleed

13
Q

Aminocaproic acid
MOA
TU

A

MOA: blocks activation of plasminogen
TU: disorders of fibrinolysis
“caps” the bleed