Other exam questions Flashcards
Best guess antibiotic for septic arthritis and osteomyelitis
Flucloxacillin
> 1 joint affected with septic arthritis
Septic emboli from endocarditis
Acute osteomyelitis in absence of injury
Children or immunosuppressed
Why are children more prone to osteomyelitis
Abundant tortuous vessels in the metaphyses of long bones
Brody abscess
Walled-off abscess in subacute osteomyelitis in children
Management of chronic osteomyelitis
Surgical debridement of seqeustra, infected bone, stabilization of bone, local antibiotic delivery systems, bone grafting, plastic surgery
Early arthroplasty infections
Staph aureus
Late arthroplasty infections
Staph epidermidis
Causative organism in gas gangrene
Clostridium perfringens
Antibiotic in gas gangrene
Metronidazole
Neurotransmitter release is caused by…
Action potential leads to calcium influx
Depolarizaration in the muscle end plate is caused by…
ACh binding and sodium influx
ACh is broken down by…
Acetylcholinesterase
Neuromyotonia
Autoantibodies against K channels causing repetitive firing
Lambert-Eaton
Autoantibodies against calcium channels causing decreased ACh release
Myasthenia gravis
Autoantibodies against ACh receptor
Curare
Competitive antagonist of ACh
Botulinum toxin
Irreversibly modifies proteins used in ACh vesicle docki ng
Botulinum toxin
Irreversibly modifies proteins used in ACh vesicle docki ng
A-delta nociceptors cause…
“First” pain caused by mechanical and thermal stimuli
Afferent functions of peptidergic C-fibres
Glutamate/substance P/neurokinin A release in the dorsal horn
Efferent functions of peptidergic C-fibres
Substance P and calcitonin gene-related peptide release from peripheral terminals, contributing to neurogenic inflammation
Overall effect of neurogenic inflammation
Hyperalgesia and allodynia
Role of prostaglandins in neurogenic pain
sensitize/activate nociceptors
