Other Pr Synthesis Inhibitors Flashcards
1
Q
Mupirocin
MOA
A
Isoleucine tRNA Synthetase inhibitor
2
Q
Mupirocin
Spectrum
A
Strep & Staph
Effective on MRSA
3
Q
Mupirocin
Clinical Use
A
- Just topical
- Wounds with staph & strep
- Yellow scab
4
Q
Streptogramins
A
- Quinopristin
- Dalfopristin
Used in combination - Bactericidal
5
Q
Streptogramins
MOA
A
مهار طولانی شدن زنجیره در ریبوزوم
6
Q
Streptogramins
Use
A
- Aerobic gr+
- VRSA
7
Q
Streptogramins
Side effects
A
- Just IV so vein inflammation, pain, edema
- Systemic: Muscle & Joint pain
8
Q
Oxazolidinones
e.g. , MOA
A
- Linezolid
- in 50s, 23s RNA, Starting complex
- Static, Cidal on strep
9
Q
Oxazolidinones
Use
A
- Aerobic gr+ cocci & rods
- VRE
- Nosocomical gr+
- Resistant & last line for cold season infections
10
Q
Oxazolidinones
Side effects
A
Reversible & mild Thrombocytopenia
