OTHERS Flashcards

1
Q

What is brugada syndrome?

A

a form of inherited cardiovascular disease with may present with sudden cardiac death
It’s rare
It affects the heart’s electrical systemic leading to abnormal heart rhythms and an icnreased risk of sudden cardiac arrest

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2
Q

What is Brugada sign on ECG?

A

incomplete/partial right bundle-branch block and convex ST elevations in the anterior precordial leads

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3
Q

How is brugada syndrome inherited?

A

In an autosomal dominant fashion

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4
Q

Who is Brugada syndrome more common in?

A

Asians

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5
Q

Whats the pathophysiology of Brugada syndrome?

A

20-40% of cases are caused by a mutation in the SCN5A gene which encodes the myocardial Na+ channel protein

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6
Q

What are symptoms of Brugada syndrome?

A

Palpitations
Syncope
Sudden cardiac arrest

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7
Q

Whats the investigation of choice for suspected Brugada syndrome?

A

Administration of flecainide or ajmaline as these make the ECG changes more apparent

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8
Q

How is Brugada syndrome managed?

A

With an implantable Cardioverter-defibrillator

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9
Q

What is Buerger’s disease?

A

Aka thomboangiitis obliterans
a small and medium vessel vasculitis
Characterised by inflammation and clotting which can ultimately lead to obstruction of blood flow and tissue damage

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10
Q

What is Buerger’s disease strongly associated with?

A

Smoking

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11
Q

What are the features of Buerger’s disease?

A

extremity ischaemia - intermittent claudication and ischaemic ulcers
superficial thrombophlebitis
Raynaud’s phenomenon

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12
Q

What are the specific rules for driving with hypertension?

A

can drive unless treatment causes unacceptable side effects, no need to notify DVLA
You must stop driving if you have malignant hypertension and you can drive again when Dr says its well controlled and BP is consistently <180/110mmHg

Bus, coach or lorry - you must tell DVLA if you have hypertension

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13
Q

What are the rules of driving after an elective angioplasty?

A

1 week off

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14
Q

What are the rules of driving following a CABG?

A

4 weeks off

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15
Q

What are the rules of driving after acute coronary syndrome?

A

4 weeks off (1 week if successfully managed with angioplasty)

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16
Q

If you have angina what are the rules with driving?

A

You can drive unless you get symptoms at rest

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17
Q

What are the rules of driving after having an ICD in?

A

if implanted for sustained ventricular arrhythmia: cease driving for 6 months
if implanted prophylactically then cease driving for 1 month. Having an ICD results in a permanent bar for Group 2 drivers

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18
Q

What are the DVLA rules for an aortic aneurysm of >/=6cm

A

Notify DVLA
Licensing will be permitted subject to annual review
An aortic diameter of =/>6.5cm disqualifies you from driving

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19
Q

What are the rules of driving following a heart transplant?

A

Do not drive for 6 weeks
No need to notify DVLA

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20
Q

What is Wellen’s syndrome?

A

An ECG pattern that is typically caused by high-grade stenosis in the LAD coronary artery
ECG features includ biphasic or deep T wave inversion in V2-3, minimal ST elevation and no Q waves

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21
Q

What is mild hypothermia?

A

32-35°C

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22
Q

What is moderate or severe hypothermia?

A

<32 degrees

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23
Q

What are signs of hypothermia?

A

shivering
cold and pale skin
slurred speech
tachypnoea, tachycardia and hypertension (mild)
respiratory depression, bradycardia and hypothermia (if moderate)
confusion/ impaired mental state

24
Q

What ECG changes may you see in hypothermia?

A

Acute ST elevation
J waves

25
What can cause palpitations?
arrhythmias stress increased awareness of normal heart beat / extrasystoles
26
What investigations should you do for palpitations?
12 lead ECG TFT U&Es FBC
27
What electrolyte disturbances can cause arrhythmias?
Hypomagnesaemia Hypokalaemia
28
What is holter monitoring?
A portable, battery-operated device that continuously records ECG from 2-3 leads Done for 24 hours usually
29
What is long QT syndrome?
an inherited condition associated with delayed repolarization of the ventricles
30
What can long QT syndrome lead to?
Ventricular tachycardia Torsades de pointes (And therefore collapse and Duden death)
31
What drugs can cause long QT sundrome?
Class 1a antiarrhythmics, amiodarone, sotalol TCA, SSRI Methadone Chloroquine Terfenadine Erythromycin Haloperidol Ondansetron
32
What can cause long QT sundrome?
Some congenital conditions Drugs Hypocalcaemia, hypokalaemia and hypomagnesaemia Acute MI Myocarditis Hypothermia Subarachnoid haemorrhage
33
Which electrolyte abnormalities can cause long QT sundrome?
hypocalcaemia, hypokalaemia, hypomagnesaemia
34
How do you manage long QT syndrome?
Avoid drugs and other precipitates Beta blockers (not sotalol!) ICD for high risk cases
35
What is Takayasu’s arthritis?
A large vessel vasculitis that typically causes occlusion of the aorta and therefore absent limb pulse More common in younger females and Asian people
36
What drug is warfarin?
Anticoagulant
37
Whats the moa of warfarin?
inhibits epoxide reductase preventing the reduction of vitamin K to its active hydroquinone form this in turn acts as a cofactor in the carboxylation of clotting factor II, VII, IX and X and protein C.
38
What are indications for warfarin?
Mechanical heart valves Second-line after DOACs: venous thromboembolism and AF
39
What factors potentiates warfarin?
liver disease P450 enzyme inhibitors, e.g.: amiodarone, ciprofloxacin cranberry juice drugs which displace warfarin from plasma albumin, e.g. NSAIDs inhibit platelet function: NSAIDs
40
What are side effects of warfarin?
Haemorrhage Teratogenic Skin necrosis Purple toes
41
What are inducers of P450 system?
Antiepilepics - phenytoin and carbamazepine Phenobarbitone Rifampicin ST Johns wort Chronic alcohol intake Griseofulvin Smoking
42
What are inhibitor of P450 system?
antibiotics: ciprofloxacin, clarithromycine/erythromycin isoniazid cimetidine,omeprazole amiodarone allopurinol imidazoles: ketoconazole, fluconazole SSRIs: fluoxetine, sertraline ritonavir sodium valproate acute alcohol intake quinupristin
43
What is dabigatran?
Oral anticoagulant
44
Whats the moa of dabigatran?
Direct thrombin inhibitor
45
What are the 2 indications of dabigatran?
Prophylaxis of VTE following hip/knee surgery Prevention of stroke in pt with non-valvular AF
46
What are SE of dabigatran?
Haemorrhage
47
What can be used for rapid reversal of dabigatran?
Idarucizumab
48
What was the RE-ALIGN study?
study showed significantly higher bleeding and thrombotic events in patients with recent mechanical heart valve replacement using dabigatran compared with warfarin. Previously there had been no guidance to support the use of dabigatran in patients with prosthetic heart valves but the advice has now changed to dabigatran being contraindicated in such patients.
49
What is bivalirudin?
A reversible direct thrombin inhibitor used as an anticoagulant in the management of ACS
50
What is clopidogrel?
An antiplatelet agent used in the management of CVD
51
What are indications for clopidogrel?
Following an ischaemic stroke in patients with peripheral arterial disease.
52
What are examples of thienopyridines?
Clopidogrel prasugrel ticagrelor ticlopidine
53
Whats the moa of thienopyridines?
Antagonist of the P2Y12 adenosine diphosphate receptor - inhibits activation of platelets
54
What is the ORBIT score for?
Predicts bleeding risk in patients on anticoagulation for afib, similar to HAS-BLED.
55
What are examples of DOACs?
Dabigatran Edoxaban Rivaroxabamn Apixaban