Ovarian And Endometrial Cycle Flashcards

(49 cards)

1
Q

How many opportunities of pregnancy

A

400 opportunities

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2
Q

Day of ovulation and its two preceding days

A

1200 days

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3
Q

Ability of the mother and the fetus to co exist as two distinct immunological system results from

A

Endocrine
Paracrine
Immunological medication of fetal and maternal tissues

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4
Q

Menstruation is regulated by

A

Hypothalamus
Pituitary axis
Ovaries
Genital tract

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5
Q

Average cycle

A

28days

Range- 25-32 days

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6
Q

Follicular phase

A

Days 1-14
Increase estrogen
Endometrial thickening
Dominant ovulatory follicle

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7
Q

Lutheal phase

A

Days 14-21
Corpus luteum produce estrogen and progesterone
Prepare the endometrium for implantation

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8
Q

Implantation

A

Blastocyst begin to produce HCG

Rescue corpus luteum in maintaining progesterone production

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9
Q

Follicular or preovulatory ovarian phase

How many Oocytes at birth?

A

2million

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10
Q

Follicular or preovulatory ovarian phase

How many follicles at puberty onset?

A

400,000

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11
Q

Follicular or preovulatory ovarian phase

How many follicles depleted every month

A

1,000 until age 35 then rate accelerates

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12
Q

Follicular or preovulatory ovarian phase

How many follicles are release during reproductive life?

A

400 follicles

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13
Q

Follicular or preovulatory ovarian phase

99.9 % undergo atresia through

A

Apoptosis

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14
Q

Recruitment of primordial follicles

A

Gonadotropin independent

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15
Q

Two members of the transforming growth factor beta family

A

Growth differentiation factor 9 (GDF9)

Bone morphogenic protein 15 (BMP-15)

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16
Q

Required for further development of large antral follicles

A

FSH

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17
Q

Begins a phase of semi synchronous growth based on their maturation state urging the FSH rise in the late luteal phase

A

Group of antral follicle (cohort)

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18
Q

FSH rise leading to follicle development called

A

Selection window of the ovarian cycle

Selection window - capacity to produce estrogen

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19
Q

Estrogen level rise in parallel to

A

Growth of dominant follicle

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20
Q

FSH induces aromatase and expansion of the

A

Antrum of growing follicles

21
Q

Most responsive to FSH is likely to be the first to produce estradiol and initiate expression of LH receptors.

A

Follicle within the cohort

22
Q

When selection window comes from

Oocyte induced oocyte growth

A

Follicle within the cohort

23
Q

LH stimulates thecal cell production of androgens then transferred to to adjacent follicles and are aromatized to estradiol

A

Late follicular phase

24
Q

Granulosa cells produce inhibin B, then to feedback on the pituitary to inhibit FSH release

A

Early follicular phase

25
Dominant follicle begins to grow. Estradiol and Inhibition production increase Decline of follicular to reach preovulatory status
Graafian follicle stage
26
95% of plasma estradiol is secreted by the
Dominant follicle
27
Ovulation Onset of gonadotropin surge from increasing estrogen secretion
Predictor of ovulation
28
Ovulation It occurs _______ before ovum release from the follicle
34-36hrs
29
Ovulation LH secretion peaks _______ before ovulation and stimulates resumption of meiosis in the ovum and release of the first polar body.
10-12hours
30
Ovulation Lose contact with one another and move outward from the oocyte along the hyaluronan polymer.
Cumulus cells
31
Corpus luteum develops from the dominant or graffian follicle remains in a process referred to as luteinization
Luteal or postovulatory ovarian phase
32
Luteal or postovulatory ovarian phase Basement membrane separating the
Granulosa lutein and theca lutein cells
33
Luteal or postovulatory ovarian phase Blood vessels and capillaries invade the granulosa cell layer
Days 2 post ovulation
34
Luteal or postovulatory ovarian phase In day 2 there's rapid neovascularazation maybe due to
Theca lutein and granulosa lutein cells
35
Luteal or postovulatory ovarian phase Cells undergo
Hypertrophy | Increase hormones
36
Luteal or postovulatory ovarian phase Corpus luteum
Low frequency | High amplitude LH pulses
37
Estrogen After ovulation, estrogen levels decrease
Secondary rise of 0.25 mg/day | 173 estradiol at the midluteal phase
38
Estrogen Secondary decline in estradiol production
End of luteal phase
39
Progesterone Midluteal phase
Production peaks at 25-50 mg/day
40
Progesterone Corpus luteum
Continues progesterone production in response o HCG
41
Transient endocrine organ
Corpus luteum
42
Corpus luteum Will regress
9-11 days after ovulation in absence of pregnancy Decrease LH luteal phase
43
Proliferative or pre ovulatory phase Fluctuation in estrogen and progesterone produce Epithelial cells
Glandular cells
44
Proliferative or pre ovulatory phase Fluctuation in estrogen and progesterone produce Stromal
Mesenchymal cells
45
Proliferative or pre ovulatory phase Epithelium is regenerated during each
Ovarian endometrial cycle
46
Proliferative or pre ovulatory phase Shed and generated from the deeper basalis layer almost 400x during the reproductive lifetime.
Suferficial endometrium (functionalis layer)
47
Proliferative or pre ovulatory phase Near the end of the menstrual cycle the coiled arteries constrict, depriving the functionalis layer of its blood supply and leading to
Necrosis and sloughing of this layer
48
Proliferative or pre ovulatory phase Most important factor in endometrial recover
Follicular phase estradiol production
49
Spontaneous, cyclical ovulation at ________ day intervals continues during almost ______ years
25-35 | 40