Ovarian Cancer

Question 1

what are the three subtypes of ovarian cancer?

Answer 1

surface/epithelial
sex cord/stroml
germ cells

Question 2

what are the two most common benign ovarian neoplasms?

Answer 2

serous and mucinous cystadenoma

Question 3

what are serous and mucinous cystadenomas derived from?

Answer 3

epithelium

Question 4

what is lining of a benign serous cystadenoma?

Answer 4

fallopian tube like ciliated serous epithelium

Question 5

what is lining of a benign mucinous cystadenoma?

Answer 5

non stratified mucinous epithelium

Question 6

what is the most common ovarian malignancy?

Answer 6

serous cystadenocarcinoma

Question 7

what is the mass of a serous cystadenocarcinoma made of?

Answer 7

cystic and solid components

Question 8

what is histo feature of ovarian serous carcinoma?

Answer 8

papillary architecture with high grade nuclei that are hob nailing

Question 9

what is a specific finding for serous carcinoma of ovary?

Answer 9

psammoma bodies

Question 10

grossly what will there be in serous carcinoma of ovary?

Answer 10

thin serous fluid around cystic areas

Question 11

grossly what will you see in mucinous carcinoma of ovary?

Answer 11

solid nodules with thick mucinous fluid

Question 12

what is endometrioid adenocarcinoma of ovary associated with?

Answer 12

endometriosis

Question 13

what are histo features of ovarian endometrioid adenocarcinoma?

Answer 13

columnar epithelium cells making glands and pink eosinophilic cytoplasm

Question 14

what is a brenner tumor made of?

Answer 14

transitional urothelial like cells

Question 15

what does a brenner tumor look like on histo?

Answer 15

nests of urothelial cells encased in a dense fibrous stroma

Question 16

what is thought to possibly lead to ovarian serous carcinoma?

Answer 16

displacement of fallopian tube cells

Question 17

what are the two common malignant sex cord ovarian tumors?

Answer 17

granulosa and leydig/sertoli

Question 18

what do granulosa tumors produce a lot of?

Answer 18

estrogen

Question 19

what do sertoli/leydig tumors produce a lot of?

Answer 19

testosterone

Question 20

what is the common benign sex cord stromal tumor?

Answer 20

fibroma

Question 21

what can an ovarian fibroma present with?

Answer 21

Meigs syndrome

Question 22

what is Meigs syndrome?

Answer 22

ovarian fibroma leads to ascites and pleural effusions

Question 23

what will an ovarian fibroma have in it?

Answer 23

collagen and spindle cells

Question 24

what is the famous histo finding of a granulosa cell tumor of the ovary?

Answer 24

Call Exner bodies

Question 25

what are call exner bodies?

Answer 25

coffee bean linear nuclie of cells

Question 26

aside from a granulosa tumor, what other ovarian malignancy can have linear nuclear grooves?

Answer 26

brenner tumor

Question 27

what is most common adult ovarain germ cell tumor?

Answer 27

teratoma

Question 28

name the five germ cell tumors an ovary can have

Answer 28

``` teratoma dysgerminoma choriocarcinoma embryonal carcinoma yolk sac tumor ```

Question 29

what is the dysgerminoma in an ovary the same as in a male?

Answer 29

seminoma

Question 30

where is tissue from in a teratoma

Answer 30

from 2 or 3 germ layers

Question 31

what is the cell type seen in a dysgerminoma?

Answer 31

fried egg cells...large tumor cell with a clear cytoplasm

Question 32

what is elevated in a yolk sac tumor?

Answer 32

serum AFP

Question 33

what is appearance of a yolk sac tumor?

Answer 33

solid mass with hemorrhage and necrosis

Question 34

what is histo finding for a yolk sac tumor?

Answer 34

schiller duval bodies

Question 35

how do schiller duval bodies appear? what are they associated with?

Answer 35

they are associated with yolk sac tumors and look like glomeruloid like structures

Question 36

what is a krukenburg tumor?

Answer 36

metastasis to ovary from the stomach

Question 37

what cell is common in a krukenburg tumor?

Answer 37

signet ring cell

Question 38

what do metastatic ovarian cancers do more often than normal ovarian tumors?

Answer 38

they are bilateral

Question 39

what are four common metastatic origins for ovarian cancer?

Answer 39

stomach colon pancreas breast GYN cancer

Question 40

what are the two types of teratomas?

Answer 40

mature and immature

Question 41

what differentiates a mature from immature teratoma?

Answer 41

the tissue is mature in a mature one and immature in immature

Question 42

what is another name for a mature teratoma?

Answer 42

dermoid cyst

Question 43

what is a struma ovarii?

Answer 43

dermoid cyst mature teratoma that is made of thyroid tissue