Ovarian tumours

Question 1

MC ovarian tumor to undergo torsion in pregnancy

Answer 1

Dermoid cyst

Question 2

MC ovarian tumour in pregnancy

Answer 2

Dermoid cyst/ mature cystic teratoma

Question 3

MC ovarian cancer in pregnancy

Answer 3

Dysgerminoma

Question 4

% of ovarian tumors undergoing malignant transformation in post menopause

Answer 4

30

Question 5

MC benign ovarian tumor in reproductive age group

Answer 5

Dermoid cyst

Question 6

Endometriosis can lead to which two types of ovarian cancers

Answer 6

Endometroid
Clear cell

Question 7

Best time for removal of a benign ovarian cyst in pregnancy

Answer 7

Second trimester

Question 8

Most common ovarian tumor

Answer 8

Epithelial

Question 9

Most common type of epithelial ovarian tumors

Answer 9

Serous

Question 10

Most important carcinogen for ovarian tumor

Answer 10

Asbestos

Question 11

Most important protective factor for ovarian cancers

Answer 11

OCPs

Question 12

Most common ovarian tumor overall

Answer 12

Serous cystadenoma

Question 13

Most common mutation associated with ovarian cancer

Answer 13

BRCA1

Question 14

% of hereditary ovarian cancers

Answer 14

10%

Question 15

Most common cancer associated with lynch syndrome

Answer 15

Colorectal

Question 16

Lynch syndrome is associated with which all cancers

Answer 16

Colorectal > endometrial > ovarian

Question 17

Genes in lynch syndrome associated with ovarian cancers

Answer 17

MLH 1
MSH 2

Question 18

Familial ovarian cancer peak age

Answer 18

50 years as compared to sporadic - 60 years

Question 19

Mutations associated with ovarian cancers

Answer 19

BRCA 1 40%
Lynch syndrome 20%
BRCA 2 15%

Question 20

Prophylactic TAH + BSO should be done until what age if a first degree relative died of familial ovarian cancer

Answer 20

TAH + BSO is only done if the patient herself has a BRCA 1 or BRCA 2 or a lynch mutation
It is not associated with a first degree relative.
Annual screening is the next best step in this case

Question 21

Ovarian cancer screening

Answer 21

TVS + Ca 125 annually only in familial heriditary cancer
Not done routinely

Question 22

Mutations associated with serous and mucinous ovarian cancers

Answer 22

BRCA1 BRCA2 p53
KRAS

Question 23

Marker for serous ovarian cancer

Answer 23

Ca 125

Question 24

Marker for mucinous ovarian cancer

Answer 24

CEA
CA 19 9

Question 25

Most common cause of pseudomyxoma peritonii

Answer 25

Ca appendix Other causes - mucoceole of appendix Mucinous cystadenoma

Question 26

Epithelial resemblance of serous and mucinous ovarian tumors

Answer 26

Serous - lining resembles the fallopian tube Mucinous - lining resembles the endo cervix

Question 27

HPE in serous cystadenoma

Answer 27

Pssamoma bodies

Question 28

State whether unilateral or bilateral Dermoid cyst Dysgerminoma Serous epithelial tumors Mucinous epithelial tumors Brenners Germ cell tumors in general Epithelial tumors in general Yolk sac tumor

Answer 28

Dermoid cyst - u/l, b/l in 10% Dysgerminoma - u/l, b/l in 20% Serous epithelial tumors - b/l Mucinous epithelial tumors - u/l Brenners 100% u/l Germ cell tumors in general - u/l Epithelial tumors in general - b/l Yolk sac tumor 100% u/l