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Flashcards in Ovary path Deck (24)
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1
Q

types of Nonneoplastic and functional cysts

A

Follicle cysts
Luteal cysts
Polycystic ovaries (PCOS)
Stromal hyperthecosis

2
Q

4 types of Ovarian tumors

A
  1. epithelial tumors
  2. germ cell tumors
  3. sex cord stromal tumors
  4. metastatic tumors
3
Q

types of epithelial tumors

A
Serous tumors
Mucinous tumors
Endometroid tumors
Clear cell carcinoma
Cystadenofibroma
Brenner tumors/Transitional cell carcinoma
4
Q

types of germ cell tumors

A

Teratomas
Dysgerminoma
Yolk sac tumor
Choriocarcinoma

5
Q

types of sex cord stromal tumors

A

Granulosa cell tumor

Fibromas, thecomas, fibrothecomas

Sertoli-Leydig cell tumors

Other sex cord stromal tumors

6
Q

PCOS Buzz words

A
Hyperandrogenism
Menstrual abnormalities
Polycystic ovaries (duh)
Chronic anovulation
Decreased fertility

Obesity
T2DM
Premature atherosclerosis

7
Q

Disorder of ovarian stroma thats most often seen in post-menopausal women

A

Stromal hyperthecosis

Uniform enlargement of ovary

Usually tan-white, solid

Often bilateral

Results in increased androgens

Similar clinical picture as PCOS

8
Q

common clinical symptoms for ovarian tumors?

A

abdominal pain, distention, GI symptoms, vaginal bleeding

9
Q

T/F Surface epithelial tumors are the most common cause of ovarian tumors

A

TRUE

10
Q

list the 5 classes of surface epithelial tumors

A
  1. serous
  2. mucinous
  3. endometrioid
  4. clear cell
  5. transitional cell

all of these above hae benign, borderline, and malignant subtypes

11
Q

list the 6 classes of sex cord stromal tumors

A
  1. granulosa
  2. fibromas
  3. fibrothecomas
  4. thecomas
  5. sertoli-leydig cell
  6. steroid (lipid) cell
12
Q

list the classes of germ cell tumors

A
  1. teratomas
  2. dysgerminoma
  3. yolk sac tumor (aka endodermal sinus)
  4. mixed germ cell
13
Q

highest malignant potential?

A

borderline; bilateral

14
Q

what are the 2 types of surface epithelial tumors? what are their respective grades and origins?

A

TYPE 1

  • low grade
  • often from borderline or endometriosis
  • include: low-grade serous, endometriod, mucinous carcinomas

TYPE 2

  • high grade
  • often from serous tubal intraepithelial carcinoma (STIC)
15
Q

Describes “tubal-like epithelium”

A

surface epithelial tumors

- serous tumors

16
Q

serous tumor gene mutation

A

Low-grade serous carcinoma
- Wild-type (normal/non-mutated) p53

High-grade serous carcinoma
- Mutated p53

Recall: p53 is a tumor suppressor gene (mutation= tumor)

17
Q

tumor microscopic appearance:

Tall mucin-containing columnar cells

A

Surface epithelial tumors

- Mucinous tumors

18
Q

Clinical condition marked by extensive mucinous ascites, implants and adhesions

A

Pseudomyxoma peritonei, AKA jelly belly

assoc w mucinous (surface epithelial) tumor

19
Q

Pseudomyxoma peritonei cause by

A

appendiceal origin

20
Q

clear cell carcinoma occur in association with which disease?

A

endometriosis.

clear cell carcinoma is a type of surface epithelial tumor

  • uncommon
  • Large epithelial cells with abundant clear cytoplasm
21
Q

which type of tumor has fibrous stroma and underlying columnar epithelium?

A

cystadenofibroma

- surface epithelial tumors

22
Q

which tumor has neoplastic cells resembling urothelium?

A

transitional cell tumors
- type of surface epithelial tumors

typically benign and unilateral

aka Brenner tumor

23
Q

T/F mature teratomas are benign

A

TRUE

  • type of germ cell tumor
  • often cystic aka dermoid cysts
  • young women
  • often incidental

contain hair, teeth, bone…

24
Q

T/F immature teratomas are malignant

A

TRUE

  • type of germ cell tumor
  • rarer
  • resembles immature fetal tissue
  • prepubertal/ teen women

histo: embryonic/ fetal tissure

MC: immature neuroepithelium