Overview of Zanidatamab

Question 1

Therapeutic antibodies can be made in the lab T/F?

Answer 1

True

Question 2

During an immune response antibodies bind to specific portions of their target molecules called____________

Answer 2

Epitopes

Question 3

The scFv of Zanidatamab binds to

Answer 3

ECD 4 of HER2

Question 4

ECD4 is known as ____________

Answer 4

Juxtamembrane extracellular receptor

Question 5

Fab of Zanidatamab binds to

Answer 5

ECD 2 of HER2

Question 6

ECD2 is known as_______________

Answer 6

The dimerization domain

Question 7

Hercetin binds to ______

Answer 7

ECD 4

Question 8

Perjeta binds to ______

Answer 8

ECD 2

Question 9

Zanidatamab causes __________ of HER 2 molecules

Answer 9

Crosslinking

Question 10

Crosslinking leads to

Answer 10

HER2 : Clustering, Internalization, Downregulation, Inhibition and Triggering

Question 11

Immune mediated responses include:

Answer 11

ADCC, ADCP and CDC

Question 12

Phase 1 study implemented a ______ trial design

Answer 12

Basket

Question 13

Part 1 was designed to identify

Answer 13

Maximum tolerated dose

Question 14

Cohort 5 of Part included

Answer 14

22 patients with HER2 + BTC
13 GBC, 4 eCCA, 5 iCCA

Question 14

Part 2 was to characterize

Answer 14

Safety, tolerability and preliminary anti tumor activity of zanidatamab

Question 14

Part 2 was to evaluate _____

Answer 14

Zanidatamab with chemotherapy in patients with HER2 expressing breast and GEA

Question 15

What was the primary endpoint of Part 2 Cohort 5 study?

Answer 15

Safety

Question 16

Key secondary endpoints were?

Answer 16

ORR, DCR, PFS

Question 17

The median age was ________

Answer 17

62.5 years

Question 18

_____ patients _____% with BTC had a partial response

Answer 18

8, 38%

Question 19

ORR in Part 2 was ______

Answer 19

38%

Question 20

Median DCR in Part 2 was ____

Answer 20

62%

Question 21

mPFS in part 2 was______

Answer 21

3.5 months

Question 22

Most common AE’s in Phase 1 were____

Answer 22

Diarrhea, Infusion reaction, fatigue and rash