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UNIT 6 HEMATOLOGY > P1 PHYSIOLOGY > Flashcards

P1 PHYSIOLOGY Flashcards

1
Q

an enzyme in RBCs enables it to transport HCO3

A

carbonic anhydrase

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2
Q

Elastic proteins present in RBCs membrane

A

ankyrin
Glycoproteins
spectrin

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3
Q

location of RBCs production during last month of gestation

A

bone marrow

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4
Q

location of RBCs production during middle trimester

A

liver
spleen , LN

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5
Q

location of RBCs production during early weeks of gestation

A

yolk sac

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6
Q

genesis of RBCs starts with which cell

A

pluripotential hematopoietic stem cell

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7
Q

Example of growth inducers needed for RBC genesis

A

IL-3

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8
Q

Example of differentiation inducers for RBC

A

low O2

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9
Q

Example of differentiation inducers for WBC

A

Infection

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10
Q

stage of RBC genesis where Hb appears

A

polychromatic erythroblast

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11
Q

B12 & B9 deficiency will cause

A

macrocytic RBC

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12
Q

life span of RBCs

A

120 days

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13
Q

hormone that stimulates RBCs genesis

A

Erythropoietin

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14
Q

factor that induces mRNA transcription leading to erythropoietin synthesis

A

Hypoxia inducible factor 1

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15
Q

B12 anemia due to lack of intrinsic factors

A

Pernicious anemia

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16
Q

storage form of iron

A

ferritin

17
Q

Carrier for iron in plasma

A

apotransferrin

18
Q

iron + apotransferrin in tissues =

A

Transferrin

19
Q

iron carrier in cells

A

apoferritin

20
Q

lack of transferrin leads to

A

hypochromic anemia

21
Q

destruction of hemoglobin is by

A

macrophages of spleen & bone marrow
kupffer cells of liver

22
Q

hormone that inhibits iron absorption & release by blocking ferroportin

A

hepcidin

23
Q

reductase enzyme that converts fe3 to fe2

A

Duodenal cytochrome B

24
Q

total body iron is regulated by

A

rate of absorption

25
Q

Portion of Hb that’s converted to bilirubin

A

Porphyrin

UNIT 6 HEMATOLOGY (33 decks)

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