P2X receptors and acid-sensing ion channels

Question 1

How many subunits compose a P2X receptor?

Answer 1

3

Question 2

P2X receptors are permeable to ?

Answer 2

Na
K
Ca
some Cl (depends on subunits)

Question 3

what is dominant among the P2X receptors
homo-oligimers or hetero-oligomers

Answer 3

homo-oligomers

Question 4

P2X receptors are

Answer 4

ligand gated ion channels

Question 5

P2Y receptors are

Answer 5

G protein coupled receptors

Question 6

what P2X receptors are hetero-oligomeric

Answer 6

P2X2 P2X3

Question 7

NH3 attaches at ____ terminus
COO attaches at ____ terminus

Answer 7

N
C

Question 8

role of lateral pores in P2X receptor

Answer 8

facilitate flow of cations

Question 9

what gates P2X receptors ?

Answer 9

ATP

Question 10

cellular damage has what effect on ATP

Answer 10

triggers vesicular release of ATP
ATP is converted to ADP

Question 11

name the agonist for P2X receptor

Answer 11

ATP

Question 12

name an antagonist for P2X recptors P2X1,P2X2, P2X3 + P2X5

Answer 12

suramin

Question 13

how are P2X receptors allosterically modulated

Answer 13

changes in pH

Question 14

P2X receptors are involved in _______________ transmission, _____________ function, ______________ in the gut, ___________ function, ____________ tone

Answer 14

synaptic cardiac excitation kidney vascular

Question 15

P2X receptors are also involved in _________ and _______________ responses

Answer 15

apoptosis
inflammatory

Question 16

location and function of P2X1

Answer 16

smooth muscle and bladder
bladder contraction

Question 17

location and function of P2X2, P2X3, P2X2/3

Answer 17

nervous system, sensory neurons
taste perception

Question 18

location and function of P2X4

Answer 18

central NS
neuroinflammation

Question 19

location and function of P2X5

Answer 19

B and T cells
inflammation
Cl conductance

Question 20

location and function of P2X6

Answer 20

B cells
pro-inflammatory immune response

Question 21

location and function of P2X7

Answer 21

lots of tissues
inflammation

Question 22

acid-sensing ion channels are gated by

Answer 22

hydrogen ions

Question 23

name the ligand for ASICs

Answer 23

hydrogen ions

Question 24

how many subunits are there in ASICs

Answer 24

3 (trimer)

Question 25

what blocks ASICs

Answer 25

amiloride

Question 26

where are ASICs expressed and what do they modulate

Answer 26

in CNS and PNS modulate neuronal sensitivity to acidosis

Question 27

what other type of channel is ASICs related to

Answer 27

ENaC also blocked by amiloride

Question 28

name the ASIC receptors

Answer 28

ASIC1a and ASIC1b ASIC2 ASIC3

Question 29

ASICs are activated by

Answer 29

changes in pH

Question 30

what do P2X receptors lack ?

Answer 30

selective ligands