Paediatrics Flashcards

(109 cards)

1
Q

What questions should be asked about the presenting illness?

A
When and how did it start?
Was he/she well before?
How did it develop?
What aggravates or alleviates it?
Has there been contact with infections?
Has the child been overseas recently?
Have the carers sought medical attention before now?
Which treatments have been tried?
Especially in infants, wet and dirty nappies, alertness and weight gain
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2
Q

What questions should be asked around PMH?

A

In utero: Any problems (abnormal bleeding, infections, Rh disease), medications, alcohol, drug use, US normal?
At birth: Gestation, mode of delivery, birth weight, resuscitation required, birth injury, malformations
As a neonate: Jaundice, fits, fevers, bleeding, special care baby unit? - How long? Later illnesses, operations, accidents, screening tests, drugs, allergies, immunisations, travel. Check red book.

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3
Q

What are the 6 week developmental milestones?

A

smiles

follows eyes past midline

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4
Q

What are the 4-6 month milestones?

A

sits with support
rolls
reaches out for objects
starts babbling

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5
Q

What are the 6-9 month milestones?

A
crawls
sits without support
pulls to stand
gives toy on request
turns head to name
responds to 'bye bye'
gestures with babbling
first tooth
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6
Q

What are the 7-12 month milestones?

A

develops pincer grasp
plays ‘peek-a-boo’
walks with a hand held
waves goodbye

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7
Q

What are the 12-15 month milestones?

A

single words
listens to stories
drinks from cup

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8
Q

What are the 18 month milestones?

A
speaks 6 words
able to walk up steps
names pictures
walks independently
scribbles
builds with blocks
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9
Q

What are the 1.5-2 year milestones?

A
kicks/throws a ball
runs
2 word sentences
follows a 2 step command
stacks 5-6 blocks
turns pages
uses a spoon
helps with dressing
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10
Q

What are the steps in the physical examination?

A
General health
Vital signs
Respiratory system
Cardiovascular system
GI system
GU system
MSK system
ENT
Anything else parents would like to be checked?
Height, weight and head circumference
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11
Q

What information can be gained in physical examination surrounding general health?

A

Is the child well or ill? Alert, lethargic, or uncomfortable / in pain? Playing is a good sign. If crying, is it high pitched or normal? Behaving normally and interacting with the parents? Any jaundice, cyanosis, rashes, anaemia, or dehydration? Neck stiffness is a rare sign in infants

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12
Q

What do you look for during the respiratory examination?

A

Is the shape of the chest normal?
Any intercostal, subcostal or sternal recession, or nasal flaring?
Use of accessory muscles?
Is there grunting or any other audible noise breathing in (stridor) or breathing out (wheeze)?
Percuss the chest for dullness
Auscultate the chest, listening for breath sounds, fine crackles, rhonchi, wheeze and pleural rub

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13
Q

What do you look for during the CV examination?

A

Check for peripheral and central cyanosis
Look for clubbing and peripheral oedema
Compare strength of femoral and right brachial pulse
Is the apex beat displaced?
Auscultate the heart with the child sitting and lying down
Listen over the apex, 2nd intercostal space left of stermum (pulmonary valve), and right of sternum (aortic valve), 4th intercostal space over the sternum (tricuspic)

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14
Q

What is fixed splitting of the second heart sound indicative of?

A

Atrial septal defect

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15
Q

What is a galloping rhythm suggestive of?

A

Congestive cardiac failure

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16
Q

What do you look for during the GI examination?

A

Child should be supine and relaxed, with knees bent
Look for distension, visible peristalsis, and hernias
Listen for bowel sounds and percuss for hepatosplenomegaly and ascites
Palpate looking for tenderness and masses (during inspiration and deep expiration)
If relevant look for anal patency, fissures and prolapse

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17
Q

What do you look for during the GU examination?

A

If relevant, examine external genitalia for evidence of ambiguity, congenital abnormality and size
Examine once only using a chaperone

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18
Q

What do you look for during MSK examination?

A

Watch the child walk and play
Examine all limbs and digits for congenital anomaly
Symmetrical skin creases on both thighs?
If <6 months check for congenital hip dislocation
Inspect the spine for dimples, hair tufts, masses or cysts at the base
Is there any abnormal curvature or posture?

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19
Q

What do you look for during ENT examination?

A

(best left until the end)
Evidence of otitis externa?
Post-auricular rash is a sign of measles, rubella and eczema
Look at the tympanic membrane - noting colour and lucency - is it perforated?
Use a spatula to check the tonsils, as well as inspecting the teeth and oral mucosa (plaques, white patches, spots, ulcers)
Can the child breathe through both nostrils
Is there a runny nose?
Check for neck lumps and lymphadenopathy

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20
Q

What is makes up ‘red’ on the traffic light system?

A

Pale, mottled, ashen blue. Doesn’t stay awake when roused. Reduced consciousness (not engaging, apathy, coma), reduced skin turgor. Any GRUNTING signs?

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21
Q

What are GRUNTING signs?

A

Grunting; weak or continuous high pitched cry; tachypnoea
Rib recession; Retraction of sternomastoid, nasal flaring, wheeze, stridor
Unequal or Unresponsive pupils; focal CNS signs, fits, marked hypotonia
Not using limbs / lying still; odd or rigid posture decorticate (flexed arms, extended legs); or decerebrate (arms and legs extended)
Temperature > or = 38 if < 6 months or >/=39 especially if cold or shutdown peripheries
I have a bad feeling about this baby
Neck rigidity, non-blanching rash, meningism, bulging fontanelle, etc.
Green bile in vomit (may = bowel obstruction, e.g. atresia, volvulus, intussusception)

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22
Q

What are common symptoms in infancy?

A
Crying
Colic
Cows' milk protein allergy
Nappy rash/diaper dermatitis
Sleep problems
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23
Q

What is the definition of colic?

A

Paroxysmal crying with pulling up of the legs, for >3h on >/= 3days/week. There is an association with feeding difficulties.

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24
Q

What advice would you give to parents with a baby with colic?

A

Movement (carry-cot on wheels) is often tried and may help
Let the baby finish the first breast first (hindmilk is easier to digest)
If breastfeeding, a low allergen diet may help, as may probiotics
Reassure strongly, reduce stress, grandparent involvement

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25
How might Cows' milk protein allergy present?
Separate entity to colic - IgE or non-IgE mediated. | It causes colic symptoms, but also GORD, blood/mucus in the stools, and may result in faltering growth
26
What are the four types of nappy rash?
1. Common 'ammonia dermatitis'. Red desquamating rash, sparing skin folds. 2. Candida / thrush. Satellite spots beyond the main rash 3. Seborrhoeic dermatitis. Diffuse, red, shiny rash extends into skin folds (occiput - cradle cap) 4. Isolated, psoriasis-like scaly plaques
27
What are the differential diagnoses for vomiting?
``` Posseting Vomiting between feeds (ask about carpets) GORD, Gastritis Over-feeding Pyloric stenosis (projectile, at ~8 weeks old) Any infection e.g. UTI Adverse food reaction Infective gastroenteritis ``` ``` Rarer causes: Pharyngeal pouch Poisoning Raised ICP Metabolic conditions i.e. DKA Almost all other conditions Bilious (green) vomiting: get urgent help ```
28
What are the differentials for an ill and feverish child?
Self-limiting viral infection Pneumonia UTI Meningitis
29
What are some problems facing babies on NICU?
``` Hypothermia Hypoxia Hypoglycaemia Respiratory distress syndrome Infection IVH (25% of = 1500g birthweight - delayed cord clamping may reduce risk) Apnoea Necrotizing enterocolitis Retinopathy of prematurity (screen) ```
30
Describe what happens with the first breath, and what can go wrong
Pulmonary vascular resistance falls, and there is a rush of blood to the lungs. Partly mediated by endogenous NO. Initiates changes from fetal to adult circulation. Process may be interrupted in various conditions e.g. meconium aspiration, pneumonia, respiratory distress syndrome, diaphragmatic hernia, group B strep infection, pulmonary hyperplasia. Pulmonary hypertension results as a consequences of these adverse events may also be primary (hypertrophy of muscular layer of pulmonary arteries.
31
What are some types of non-invasive ventilation for neonates?
CPAP (continuous positive airways pressure) NIPPV (nasal intermittent positive pressure ventilation) HFNC (high-flow nasal cannula)
32
What are some types of invasive ventilation for neonates?
TCPL (time cycled pressure limited ventilation) PTV (patient-triggered ventilation) HFV (high-frequency ventilation)
33
What might be the presentation of neonatal sepsis?
Signs may be non-specific and subtle. Labile temperature, lethargy, poor feeding, respiratory distress, collapse, DIC.
34
How would you manage suspected neonatal sepsis?
ABC Supportive (ventilation, volume expansion, inotropes) Bloods for FBC, CRP, glucose Blood cultures (results take 48h) CXR Lumbar puncture for culture, glucose, protein count, WCC and Gram stain Failure to responsd within 24h investigate further with stool sample for virology, throat swab, serology for herpes virus, urine CMV culture, VDRL (syphyllis)
35
What antibiotics would you give in early-onset neonatal infection?
Broad spectrum i.e. benzylpenicillin + gentamicin until culture results are available. Stop if well and cultures negative. Continue treatment for 7 days if +ve cultures. In meningitis suspected then give cefotaxime
36
What antibiotics would you give in late-onset neonatal infection?
Broad spectrum e.g. flucloxacillin + gentamicin until cultures available Cefotaxime if meningitis is likely Coagulase -ve Staph is more likely in a preterm infant with CVP line - give vancomycin + discuss removal of line
37
What are the risk factors for early onset neonatal sepsis
Prolonged rupture of membranes >18h Maternal infection; maternal pyrexia, chorioamnionitis, UTI Mother carrier of Group B strep (GBS) from vagina or urine, or previous infant affected by it Preterm labour Fetal distress Breaks in neonatal skin or mucosa (caused by organisms acquired from the mother)
38
What are the risk factors for late-onset neonatal sepsis?
Central lines and catheters Congenital malformations e.g. spina bifida Severe illness Malnutrition Immunodeficiency (tends to be caused by environmental organisms)
39
How common are neonatal seizures?
~4/1000 births - most occur 12-48h after birth. May be generalised or focal, tonic, clonic or myoclonic
40
What are the causes for neonatal seizures?
Hypoxic-ischaemic encephalopathy (due to antenatal or intrapartum hypoxia/ respiratory distress) Infection (meningitis/encephalitis) Intracranial haemorrhage / infarction Structural CNS lesions (focal cortical dysplasia/tuberous sclerosis) Metabolic disturbance (hypoglycaemia, hypocalcaemia, hypo/hypernatraemia, hypomagnesium) Metabolic disorders (urea cycle disorders / amino acid metabolism) Neonatal withdrawal from maternal drugs or substance abuse Kernicterus (hyperbilirubinaemia) Idiopathic seizures e.g. benign 5th day fits
41
How would you treat a neonatal seizure?
ABC - Help Rule out and treat reversible causes i.e. hypoglycaemia Start empirical antibiotics IV access and take blood for FBC, U+E, LFTs, calcium, magnesium, glucose and blood gas If available, start CFAM Consider cranial US and MRI Specialist tests include toxicology screening, serum ammonia, urine organic acids, serum amino acids, karyotype and TORCH screen. Treat cause
42
What is hypoxic-ischaemic encephalopathy (HIE)?
A clinical syndrome of brain injury secondary to a hypoxic-ischaemic insult
43
What are the causes of HIE?
Antenatal, intrapartum up postpartum causes e.g. cord prolapse, placental abruption, maternal hypoxia (any cause) or inadequate postnatal cardiopulmonary circulation.
44
What are the causes of shock in a neonate?
``` Blood loss (placental haemorrhage, twin-twin transfusion, IVH, lung haemorrhage) Capillary plasma leaks (sepsis, hypoxia, acidosis, necrotizing enterocolitis) Fluid loss (D&V, inappropriate diuresis) Cardiac causes (hypoxia, left to right shunts, valve disease, coarctation) ```
45
What should you ask before examining a neonate if not taking a history?
Birthweight normal? Birth and pregnancy normal? Mother Rh-ve? Enlist mothers help, explain aims and listen if mother talks
46
What do you look for when examining the head of a neonate?
Circumference Shape (odd shapes from a difficult labour quickly resolve) Fontanelles (tense or sunken) Eyes - red reflex, corneal opacities, conjunctivitis Ears - shape, position, low set? tip of the nose in white babies when pressed will be jaundiced. Shut the mouth to test breathing through the nose (choanal atresia). Oto-acoustic screening done? Complexion - cyanosed, pale, jaundiced, or ruddy (polycythaemia)? Mouth - Look inside, insert a finger: palate intact? suck good? does baby's face look normal?
47
What do you look for when examining the arms and hands of a neonate?
Single palmar creases? (normal or trisomy 21) Does baby look like the parents? Waiter's tip sign of Erb's palsy of C5 and 6 trunks Number of fingers Clinodactyly (5th finger curved towards ring finger (normal or trisomy 21)
48
What do you look for when examining the thorax of a neonate?
``` Watch respirations Not grunting, recessions Palpate the precordium and apex beat Listen to the heart and lungs Inspect the vertebral column for neural tube defects ```
49
What do you look for when examining the abdomen of a neonate?
Expect to feel the liver. Any other masses? Inspect the umbilicus, is it healthy? Assess skin turgor Inspect genitalia and anus, are the orifices patent? Ensure in the first 24hr baby passes urine (if not consider posterior urethral valves in boys) and stool (if not consider Hirschprung's, CF, Hypothyroidism) Is the urinary meatus misplaced, are both testes descended? Neonatal clitoris looks large, if very large consider CAH Bleeding PV may be a normal variant following maternal oestrogen withdrawal
50
What do you look for when examining the legs of a neonate?
Test for development dysplasia of the hip Avoid repeated tests as it hurts, and may induce dislocation Feel femoral pulses to 'rule out' coarctation Note talipes Toes - too many, too few, too blue?
51
What do you look for when examining the buttocks/sacrum of a neonate?
Is there an anus? Are there 'mongolian spots'? Tufts of hair +/- dimples suggest bifida occulta - if you can't see the bottom of a dimple, arrange US Any pilonidal sinus?
52
What do you look for when assessing the CNS of a neonate?
Assess posture and handle the baby Intuition can be most helpful in deciding if the baby is ill or well Is he jittery (hypoxia, ischaemia, encephalopathy, hypoglycaemia, infection, hypocalcaemia)? There should be some control of the head Do limbs move normally? Is the tone floppy, or spastic? Are responses absent on one side (hemiplegia)? Moro reflex Stroke palm to elicit grasp reflex Is the baby post-mature, small for dates, or premature?
53
What are the signs of pneumonia?
Raised temperature Malaise Poor feeding Respiratory distress: tachypnoea, cyanosis, grunting, intercostal recession, use of accessory muscles (older children may have typical lobar signs - pleural pain, crackles, bronchial breathing)
54
When should you admit for pneumonia?
If SpO2 is <92%; signs of respiratory distress
55
What tests should you order when suspecting pneumonia?
CXR Bloods: FBC/ blood and sputum cultures if severe Not required in community acquired pneumonia if a child is going home
56
How would you treat pneumonia?
Amoxicillin is 1st line | Alternatives: co-amoxiclav, axithromycin, clarithromycin
57
Which bacteria typically cause pneumonia?
Pneumococcus, Mycoplasma, Haemophilus, Staphlycoccus, (Tb, Viral)
58
What are the signs of croup?
Stridor, Barking cough, Hoarseness from obstruction in the region of the larynx
59
What is the typical epidemiology of croup?
<6yrs but can be recurrent in older, atopic children | Autumn
60
What are the causes of croup?
Parainfluenza virus (1, 2, 3) Respiratory syncitial virus Measles (rare)
61
What is the pathology of croup?
Subglottic oedema, inflammation and exudate
62
What is mild croup?
Minimal recession / stridor, no cyanosis, alert child, good air entry Can be sent home if settles w/ Tx
63
How would you treat mild croup?
Dexamethasone (0.15mg/kg PO) or prednisolone 1-2mg/kg
64
If there is a poor response to treatment in a child with croup, what should you do?
Adrenaline via nebuliser 1:1000 (400mcg/kg up to 5ml) | If poor response again, repeat and take to ITU
65
If there is failure to improve with steroids/nebulised adrenaline in croup what should you consider?
Bacterial tracheitis
66
How would you manage epiglottitis?
Avoid approaching child, don't examine throat, don't cannulate. Senior help. Inhalation induction and EUA if necessary Cause may be Haemophilus influenzae type B (Hib) - treat with cefotaxime, 25-50mg/kg/8h IV
67
What is the differential for stridor in babies?
``` Viral croup Bacterial tracheitis Epiglottitis Inhaled foreign body Laryngomalacia ```
68
Define asthma
Reversible airway obstruction (peak flows vary by >20%) +/- wheeze, dyspnoea or cough (10% of the population is affected)
69
What risk factors exist for asthma?
``` Low birthweight FHx Bottle fed Atopy Male Pollution Past lung disease ```
70
What gene causes susceptibility to asthma?
ADAM33
71
What are some triggers for asthma?
``` Pollen House dust mite Feathers Fur Exercise Viruses Chemicals Smoke Traffic ```
72
What is the differential diagnosis of asthma?
``` Foreign body Pertussis Croup Pneumonia / TB (do CXR) Hyperventilation Aspiration CF (wet cough, starting at birth, failure to thrive) ```
73
How should you treat asthma exacerbations?
Treat early - rescue prednisolone 30-40mg/day if >5yrs or 20mg/day if 2-5 years for 5 days
74
What should be the general management of a child with asthma?
Annual review of symptoms, exacerbations, oral steroid use, and time off school or nursery, check inhaler technique and medication adherence, make a personalised self-management action plan, advice regarding tobacco smoke exposure, record height and weight on centile charts
75
What is the first line drug therapy for asthma?
Occasional Beta-agonist via pMDI e.g. salbutamol 100mcg - use spacer
76
What is the second step in drug therapy for asthma?
Add inhaled steroid e.g. beclometasone - 50mcg use up to 200mcg / 12hr (i.e. 4 times in 12 hrs)
77
When should you add the second step of treatment to a patient with asthma?
If beta-agonist is needed >3 times per week (also if >5yrs and many exacerbations, or asthma wakes from sleep >once per week)
78
If first two steps of asthma treatment are not working, what should you do next?
Review diagnosis. Check inhaler use/concordance. Eliminate triggers. Monitor height. If <5yrs: Add 1 evening dose of Montelukast 4mg If >5yrs: Consider respiratory review. Can try salmeterol (LABA). If symptomatic then increased inhaled steroid and try motelukast 5my or theophylline
79
How should you treat severe asthma acutely?
Sit up - high flow 100% oxygen Salbutamol: 5mg O2 nebulised in 4ml saline with ipratropium bromide 0.25mg Hydrocortisone or prednisolone Consider one IV dose of magnesium sulphate 40mg/kg over 20 mins Aminophylline 5mg/kg IV over 20 mins
80
What is classed as a near fatal / life threatening acute asthma exacerbation?
``` Respiratory acidosis and/or requiring mechanical ventilation with increased ventilation pressures Any one of the following: PEFR <33% predicted Sats < 92% Silent chest Cyanosis Feeble respiratory effort Bradycardia, dysrhythmia, hypotension Exhaustion, confusion, coma ```
81
What is classed as an acute severe asthma exacerbation?
``` Any one of: PEFR 33-50% predicted RR: 2-5yrs > 40/min ; 5-12 yrs >30/min ; >12yrs >25/min Pulse: >140bpm, >125, >110 Inability to complete sentences Use of accessory muscles ```
82
What is classed as a moderate asthma exacerbation?
Increasing symptoms PEFR 50-70% best or predicted No features of severe asthma
83
What is classed as brittle asthma?
Type 1: wide variability in PEFR despite intensive therapy | Type 2: sudden severe attacks despite apparently well controlled asthma
84
What is the commonest lung infection in infants?
Acute bronchiolitis
85
What are the features of acute bronchiolitis?
``` Coryza preceds cough Fever (sometimes) Tachypnoea Wheeze Inspiratory crackles Apnoea Intercostal recession +/- cyanosis +/- fever ```
86
What are the causes of acute bronchiolitis?
Typically - Respiratory syncytial virus (RSV) | Others - Mycoplasma, parainfluenza, adenoviruses.
87
Who is most at risk in acute bronchiolitis?
<6 months old | underlying conditions
88
What signs in acute bronchiolitis should prompt admission?
Inadequate feeding Respiratory distress Hypoxia
89
If the acute bronchiolitis is severe, what should you do?
CXR to exclude pneumothorax or lobar collapse Blood gases/ SpO2 FBC
90
How would you treat acute bronchiolitis?
Oxygen (stop when SpO2 >/=92%) Nasogastric feeds 5% of those need respiratory support (mostly CPAP) (mortality roughly 1%; 33% if symptomatic congenital heart disease)
91
What can be given to immunocompromised children to try and prevent bronchiolitis?
Ribavirin
92
What is viral-induced wheeze?
Cough and wheeze. Too young for diagnosis of asthma to be made confidently. These infants often end up being treated with escalating bronchodilator therapy with frequent courses of antibiotics against uncultured organisms. Non-atopic disorder. RSV more often than haemophilus. Spectrum.
93
What is at the lower and upper end of viral induced wheeze severity?
Lower end is 'happy wheezers' i.e. undistressed | Upper end is CF in those with loose stools and failure to thrive
94
What gene mutation causes CF?
Mutations of the transmembrane conductance regulator gene (CFTR) on chromosome 7, which codes for a cyclic AMP-regulated sodium/chloride channel.
95
Broadly, what are the problems / pathology in CF?
Varying severity of exocrine gland function. Meconium ileus in neonates (and its equivalent in children), lung disease akin to bronchiectasis, pancreatic exocrine insufficiency, raised Na+ sweat level - in 85% of mutations.
96
How do you diagnose CF?
All newborns are screened looking for an abnormally raised immunoreactive trypsinogen, and 29 CFTR mutations on the Guthrie card (85% coverage). 10% present with meconium ileus as neonates Later presentation is with: - Recurrent pneumonia - Failure to thrive - Slow growth - Fatty, oily, pale stools are reflective of steatorrhoea
97
What is a positive finding in the sweat test for CF?
<40mmol/L is normal. >60mmol/L supports the diagnosis. Intermediate results are suggestive but not diagnostic.
98
What can cause false positive results in the sweat test?
``` Up to 25% of normal newborns show a sweat sodium concentration >65mmol/L (rapidly declines on the 2nd day after birth) Atopic eczema Adrenal insufficiency Ectodermal dysplasia Some types of glycogen storage disease Hypothyroidism Dehydration Malnutrition ```
99
What can cause false negative results in the sweat test?
Oedema | Poor technique when testing
100
What is meconium ileus and how is it managed?
Presents with failure to pass stool or vomiting in the first 2 days of life. Distended loops of of bowel are seen through the abdominal wall. A plug of meconium may show in one of the loops. NG tube drainage / washout enemas / excision of gut containing meconium
101
How should you manage respiratory problems in CF?
Physiotherapy 3x per day Educate parents - teach percussion and postural drainage Older children learn forced expiration techniques
102
What respiratory infections can occur in CF?
``` Staph aureus H. influenzae (rarer) Strep pneumoniae (younger children) Aspergillosis (in adolescents) Eventually >90% are chronically infection with pseudomonas aeruginosa ```
103
What GI problems do CF patients experience?
Energy needs rise by ~130% due to malabsorption and chronic lung inflammation Most need enzymes for pancreatic insufficiency Omeprazole helps absorption by increasing duodenal pH Vitamins needed Diet should be high protein / high calorie
104
What is the prognosis for CF patients?
Death from pneumonia or cor pulmonale. Most survive to adulthood. Median survival is >31 years, and possibly >50 for those born after 2000
105
How does acute otitis media present?
Rapid onset pain Fever +/- irritability Vomiting (often after a viral URTI)
106
What are some common organisms that cause otitis media?
Pneumoccocus Haemophilus Moraxella Other streps and staphs
107
What causes pain in acute otitis media?
Bulging tympanic membrane which is relieved if it perforates
108
How should you treat acute otitis media?
Analgesia Resolves in >60% within 24hours without antibiotics Consider immediate antibiotics if systemically unwell, immunocompromised or no improvement in >4 days Amoxicillin for 5 days if required
109
What are some complications of otitis media?
Mastoiditis | Petrositis, labrynthitis, meningitis, abscess etc (rare)