Paediatrics/mens health/urinary Flashcards

(56 cards)

1
Q

How can you involve a child in a consultation, and what key observations should you make?

A
  • Prep the child about what will
    happen in the consult.
  • Include the child in the discussion.
  • Give the child time to answer.
  • Do not talk over the child.
  • Change descriptions / questions into child-relatable
    things: “Tell me about your tummy ache? Where is it?”
  • Observe any physical cues and appearances:
    – How does the child react to their environment? Are
    they shy, confident, talkative, happy, sad, or tired?
    – How do they sit? Do they slump, wriggle
    or hug their knees to their chest?
    – How do they look? Pale, robust, reddish, dark circles under eyes.
  • Work through the plan with them. If age appropriate, children may
    respond to ‘fairy potions’, ‘witchy brews’ or ‘green dinosaur drinks’
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2
Q

What should you be aware of when choosing supplements and a diet plan for children?

A

Infants and children are sensitive to the ingestion
of man-made nutrients and supplements.
* Work with organic food. Hide foods if required for ‘fussy
eaters’ (e.g. leafy greens in smoothies, sauces, etc.).
* chewable or powderedsupplements are a great choice on their own or in food.
Liquids can be disguised in juices, smoothies or jellies.
* Maple syrup, cocoa powder, dates, organic yoghurts
and frozen banana / berries are excellent at hiding the
taste of supplements that kids won’t take on their own.

  • Avoid limiting a child’s diet; focus on adding in nutrient-dense foods.
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3
Q

How do you adjust the doses of supplements for specific ages of children?

A
  • Infants still breastfeeding: dose the mother
  • infants under two: fried’s rule
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4
Q

Why is digestive health paramount in children, and how can you optimise this?

A
  • A young child’s digestive tract is far less developed / matured and hence more sensitive than an adult’s-
    Without anoptimally functioning GIT, health can quickly be thrown out
    of balance. This can cause significant issues as they age.

Therapeutics
must be gentle and the dose appropriate. Avoid
harsh protocols like anti-candida diets or enemas.
* Optimise physiological functions as well as
biochemical pathways through organic seasonal food,
gentle herbal teas (e.g., chamomile, rosehip and nettle are excellent)
as well as fresh vegetable juices to achieve optimum balance.

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5
Q

5 examples of supplements that are too harsh for children, and what would you do instead?

A

1) Psyllium husk: Slippery elm powder or marshmallow root;
soaked flaxseed mucilage blends well.
2 Anti-candida diet * Remove sugar, dose with S. boulardii and probiotics. Essential oils, e.g.,
oregano, thyme
3) Avoid essential oils ― use fresh garlic, thyme,
oregano as antimicrobials (i.e. garlic bread)
4) Turmeric * Add to non-spicy curries. Bitterness of turmeric
is too overpowering for jellies or smoothies
5)Spirulina powder * Chlorella liquid with peppermint.

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6
Q

How can an infants microbiome in the first month of life effect them later on?

A

A lower microbiome diversity increases the risks of obesity, Type II
diabetes and chronic inflammatory illnesses (e.g., IBD, asthma).
* A higher microbiome diversity is linked to healthy
nervous system / brain development and the
appropriate stimulation of the immune system.
* Studies have also found a higher diversity in an infant’s microbiome
helps the body react appropriately to vaccines and other pathogens.
* There are multiple ways that an infant’s microbiome is established and
fostered; prenatally in utero, during delivery, and postnatally through
environmental factors and abundance or absence of breastfeeding.

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7
Q

What are the health implications of how a baby is born?

A

Vaginal birth: Picks up the mother’s microbiome
on passage through the vaginal canal and when passing the rectum.
* Caesarean delivery: Avoids this transmission; a higher rate of maternal
antibiotics. Studies are looking to see if maternal faecal transplantation
can normalise caesarean-born infants’ microbiomes. Vaginal seeding
can be an option on a birth plan if the mother’s microbiome is healthy.
* Also consider excessive pressure from an assisted
birth (i.e., forceps, ventouse) — can interfere with
breastfeeding through compression of cranial
bones (e.g., occipital, parietal) and cranial nerves
(e.g., hypoglossal).
Optimise maternal
microflora before birth
and use probiotics asap
post C-section delivery.

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8
Q

How does colonisation of microbiota differ with vaginal and c section birth?

A

Vaginal-born infants have a high abundance
of Bacteroides spp., Bifidobacterium,
Lactobacillus, Enterobacter and Streptococcus.
* Caesarean-born infants have good levels of
Lactobacillus, but lower levels of Bifidobacterium
and higher levels of Clostridium and Staphylococcus.
* Low levels of Bifidobacterium in early life have been
correlated to higher rates of atopic disease later in life.
* Colonisation rate of gut microbiota in vaginal-born infants
is higher in the first week of life compared to C-section-born infants

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9
Q

What are the benefits of microbiome diversity?
What vitamins do bifidobacterium produce?

A

The benefits of microbiome diversity
(esp. of Bifidobacterium spp.) include:
* Enhanced lactose digestion.
* Intestinal wall integrity (via
short-chain fatty production).
* Innate immunity development.
* Peristalsis stabilisation.
* Production of organic acids
and bacteriocins.
* Production of antimicrobial and
iron-scavenging compounds.
Bifidobacterium
spp.:
Predominant vitamins
produced:
B. bifidum
B. infantis
Thiamine, folate, biotin,
nicotinic acid
B. breve
B. longum
Riboflavin, pyridoxine,
cobalamin, ascorbate

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10
Q

What is breastmilk colonised with and how does this happen?

A
  • Breastmilk is heavily colonised with Bifidobacterium spp. and Lactobacillus spp. including B. breve, B. bifidum, B. adolescentis, L. gasseri, L. fermentum, L. plantarum, L. rhamnosus, and L. salivarius.
  • The breastmilk microbiome is fostered via translocation of the maternal gut microbiome to the breast tissue. Dendritic cells open the intestinal tight junctions and sample the mother’s GI microbiome. Macrophages then transport bacteria to breast tissue via the lymph, thus colonising the breast milk.
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11
Q

How can a child’s microbiota effect the neurodevelopment of a child? How can temperament and cognitive scores be effected?

A
  • A diverse microbiome colonisation is essential
    for the development of the CNS and ENS.
  • Absence of an established microbiota has been linked to:
    ‒ Underdevelopment of the myenteric plexus.
    ‒ Hypersensitivity of the HPA-axis stress response.
  • Normalisation of the microbiota has been shown
    to reduce the stress response in young children.
  • The critical window for optimising the gut-brain
    axis connection through diverse microbiome
    colonisation is from birth to 3 years
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12
Q

Signs/ symptoms/ causes of infantile colic?

A

Infantile colic = regular prolonged crying of
unknown cause in an otherwise healthy infant.
* Signs / symptoms: Infant appears in pain,
crying for long periods and often stiffens
their body / curls their legs upwards. It usually occurs within
weeks of birth and usually resolves itself by 3‒4 months of age.
* Causes (hypotheses): Undeveloped digestive
system, trapped gas, food intolerances from breast
milk or formula (e.g., dairy), low GI microbiota
diversity, newborn over-stimulation as it often occurs late
afternoon early evening i.e., predictable times each day.

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13
Q

Natural approach to infantile colic?

A

1) Burping them for as long as they feed- This reduces trapped air in the intestines.
2) Maternal and baby probiotics. Baby-administered L. reuteri has been shown to reduce colic symptoms in breastfed babies.
3) Place gentle pressure on the abdomen via ‘tiger hold’ Gentle bicycling of infant’s legs or agentle abdominal massage using a chamomile and mandarin
essential oil blend (or lavender) — clockwise only.

4) Fennel seed tea — antispasmodic, carminative
and galactagogue. 3‒6 cups of fennel tea
daily for the mother. Place 1 tsp in 300ml of
water and boil for 10‒15 mins. Drink through the
day. For formula babies — give 1 tsp of boiled
but cooled mixture before feeds or in the milk.
* Chamomile tea (cooled, boiled) — carminative,
nervine, antispasmodic. If administered to the
baby, give an age-adjusted dose of fennel or
chamomile based on an adult dose of 5 ml x
3 daily.

5) Checking for intolerance in breast milk / formula.
Common problem foods: Dairy, chocolate,
eggs, soy, caffeine, lentils and spicy foods.

6) Avoid gas-forming foods e.g., crucifers, fried foods, peanuts, wheat.

7) Remove excess stimulus — loud noises, busy rooms,
flashing lights, screens. Ensure the room is dark (with lights
remaining dimmed when waking); use white noise to aid sleep.

8) Create closeness — swaddling, carrying in a baby sling and
breastfeeding on demand can help. Also feed in quiet surroundings.

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14
Q
A

Pre and probiotics are vital for the microflora of any infant or
child, especially if born via C-section and formula fed:
* Prebiotic — colostrum and breastmilk in infants and prebiotic foods
in children; use a variety of vegetables, beans, lentils, kefir, yoghurt,
kombucha, miso for mother and for children once weaned.
Prebiotic formulae containing GOS ↑ Bifidobacterium spp.
* Probiotic — focus on age-appropriate species / formulas
i.e., Bifidobacterium spp. if dosing an infant or if digestion
has never been fully established in a young child.
* Supplementation 0–4 months — can be via the
mother, probiotic powder rubbed onto the nipple before feeding, or
powder gently rubbed inside the infant’s mouth with a clean finger.

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15
Q

What is the effect of the microbiome on infant immunity?

A

A healthy microbiome has a positive influence on infant immunity.
* Infants are born Th2 dominant; environmental bacteria and the microbiome are needed to normalise immune function.
* Th2 dominance = ↑ IgE production + sensitivity to allergens.
* Alterations in the infant microbiome can drive intestinal
permeability, as well as GI and systemic inflammation.
* Lactobacillus spp. produce lactic acid and bactericidins that alter the environment to prevent inflammatory bacterial spp. from colonising.
* Staphylococcus aureus colonisation in the infant gut has been associated with elevated inflammatory cytokines, suggesting that
dysbiosis increases an infant’s tendency to inflammation.

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16
Q

Natural approach to teething?

A
  • Signs / symptoms: Irritability, mild temperature (38° C), 1 flushed
    red cheek / ear, constant dribbling, diarrhoea, gnawing and chewing.
  • Natural approach:
    ‒ Give them a cold wet muslin to chew. Older babies can
    chew chilled cucumber / carrot / celery sticks, frozen banana or homemade frozen lollies (e.g., frozen breastmilk or berry juices).
    ‒ Rub babies’ gums with a clean finger.
  • The combination of nervine herbs soothes a baby and eases pain.
  • Ingredients (½ ounce each of): Dried chamomile flowers,
    dried lemon balm, dried lavender flowers, dried catnip leaves.
  • Instructions: Combine all the herbs in a jar.
    Infused 1 tbsp in 300 ml of boiling water for
    15 minutes. Increase to 30 minutes or use
    2 tbsp for a very irritable baby (or mum!).
    Can be drunk by the mother or dip a washcloth in tea for
    the baby to chew on. Also can be given by spoon or dropper.
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17
Q

Natural approach to coughs, colds and fevers

A

Natural approach — therapeutic foods:
* Garlic — freshly grated / crushed garlic onto food (e.g., garlic bread)
to increase allicin, which is anti-microbial, immune-boosting
(↑ NK cells and interferons) and mucolytic. Use over the age of 1.
* Finely chop onion and smother with manuka honey.
Leave for 1‒2 hours. The onion’s phenolic compounds
are anti-microbial and anti-inflammatory; the honey’s
anti-microbial properties are attributed to its high levels
of methylglyoxal. Give 1 tsp 2‒3 times per day. Good for sore throats. * Freshly grate ginger in hot water, leave to cool and add lemon
and honey to taste. Sip at regular intervals. Anti-inflammatory
(inhibits LOX, COX and TNF-α) and anti-microbial.

  • Vitamin C — effective at preventing
    and relieving symptoms of viral respiratory infections.
    Up-regulates interferons, natural killer cells and T-cells.
  • Zinc — increases phagocyte, natural killer cell, T- and B-cell activity. Inhibits viral replication. ↓ inflammatory cytokines such as Il-6.
  • Vitamin A — critical for epithelial cells and mucous membranes,
    growth and development. Regulates humoral and cellular
    immune response, enhancing T-cell proliferation.
  • Vitamin D — modulates adaptive and innate immunity.
    Deficiency is associated with decreased immunity.
    28
  • Probiotics — regulate adaptive and innate
    immunity as well as immunomodulatory function.
  • Iron — include iron-rich foods and consider checking
    ferritin — required for immune cell maturation and proliferation.
  • Selenium — important for T-lymphocyte proliferation and activity,
    antibody production and regulating excessive immune responses.
  • All foods high in antioxidants — they can protect
    and minimise damage from infection. Use
    antioxidant foods in juices, smoothies, add to
    salads, sauces or roast them into edible hot chips.
    29
    Coughs, Colds & Fevers
    (Soyano et al.1999; Cherayil, 2010 ; Yan
    et al. 2011; Huang et al. 2012; Cronin et
    al. 2019; Zhang et al. 2020)
    © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD.
    Natural approach — herbal medicines:
  • Echinacea purpurea / angustifolia adult dose 20 drops tds —
    immunomodulatory through actions of alkylamides. Be careful of use
    in those under 3 years and discontinue if any child develops a rash.
  • Thymus vulgaris [thyme] adult dose 10 drops tds — antimicrobial
    (↑ cell membrane / wall permeability), expectorant, antispasmodic.
  • Verbascum thapsus [mullein] adult. dose 10 drops tds, expectorant.
  • Sambucus nigra [elder] adult dose 20 drops tds — antiviral,
    expectorant, anti-inflammatory, antioxidant. Syrup can also be used.
  • YEP tea [yarrow, elderberry and peppermint] adult dose 1 cup tds
    — diaphoretic, immune-supporting blend. 1 tsp of each herb in a pot
    of 200 ml water and bring to the boil. Simmer for 15 min and strain.
    30
    Use Young’s
    rule to find age Coughs, Colds & Fevers appropriate dose
    Drops of tincture 1:3
    © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD.
    Natural approach — practical solutions:
  • Vaporiser in room at night with essential oils of tea tree, chamomile
    and cajeut (lemon and lavender when under 6 months).
  • Ensure room is dust free and adequately ventilated.
  • Older children can use a saline nasal spray to help clear sinuses.
    Tissue salts: 3 x daily for as long as the symptoms improve.
  • Ferrum phos — if there is inflammation.
  • Nat. mur. — at the start of a cold where there is a clear runny nose.
  • Kali. mur. — wet cough with thick and white discharges.
  • Kali. phos. — wet cough with thick golden yellow discharges.
  • Kali. sulph. — wet cough with yellow-green discharges.
    31
    Coughs, Colds & Fevers A salt pipe can also be
    used by older children.
    © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD.
    32
    Coughs, Colds & Fevers
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18
Q

How can fevers be benificial?

A

Fevers are an essential component of the immune
system. Fever in children — benefits (if 38‒40° C):
* Beneficial in developing T-cell differentiation. In fact,
T-cells that were exposed to hyperthermia prior to
differentiation were found to be better able to respond
rapidly and effectively in future immune responses.
* Increases heat shock proteins (HSP), which are immune
chaperones. They appear to regulate viral infections by
influencing host cell entry, viral replication and gene expression,
folding / assembly of viral proteins and apoptosis regulation.
* Unless the fever starts creeping above 40° C, it is generally best
to let it be and support as needed. Do not suppress this process.

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19
Q

How can you naturally support a fever in children?

A

Tepid bathing — not cold bathing as this can
induce seizure. This should encourage mild peripheral vasodilation.
* ACV socks — soak socks in warm ACV, squeeze excess
out and then place onto the feet. This encourages peripheral
vasodilation to help reduce the core body temperature.
* Homeopathics: Taken every 30 mins, up to 6 doses.
‒ Aconite 30 C: When a fever, cold, sore throat or
earache comes on rapidly from cold exposure.
‒ Belladonna 200 C: High temperatures of 40° C.
Child is red in the face and may start to hallucinate

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20
Q

What is otis media and what are some causes/ risk factors?

A

Otitis media = infection of the middle ear often accompanied
by cold and flu symptoms and child holding or rubbing their ear.
Otitis media with effusion / glue ear = collection of fluid in the middle
ear without signs of acute inflammation. Often follows acute otitis media.
* Causes / risk factors:
– Common between 3 months and 4 years of age
(when the eustachian tube is more horizontal).
– Under-functioning immune system (e.g., poor nutrition, dysbiosis).
– Non-infective causes, e.g., food allergies, environmental irritants,
GORD, dental problems, temporomandibular joint misalignment

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21
Q

Natural approach to Otis Media?

A

Natural approach:
* If a bottle-fed infant, encourage parents to bottle feed in
an upright position to reduce eustachian tube compromise.
* Reduce or remove dairy (increases mucus production).
* Hot or cold compresses on the ear using a flannel or cloth.
* Mix 1 drop of tea tree oil with 5 ml olive oil and gently rub around
the opening to the ear. Garlic oil can be used in the same way.
Take 50 ml of EVOO and chop 1 garlic clove into it. Let it sit for
24 hours+. Rub onto the opening of the ear (not into the ear canal).
* Remove possibly allergens, e.g., dairy, gluten, citrus.
* Explore potential dental / TMJ issues as appropriate.
36
Otitis Media Use all therapeutics
in Cold and Flu
section above
Provide
warm foods
to promote
warmth in
the body & ↓
congestion.
© CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD.
37
Natural approach — homeopathy:
Ho
Aconite: Outer ear is hot, red, swollen and very sensitive to noise.
Comes on from cold wind exposure.
Belladonna: Throbbing or pulsating pain in middle and external ear with
accompanying high fever.
Chamomilla: Acutely painful earache from heat exposure, wind exposure or
emotional upset. One cheek red, the other pale.
Merc. sol: Earache at night, typically of the right ear with thick yellow-green
offensive discharge. They feel better with a cold compress.
Pulsatilla: Every cold develops into an earache. Fullness or bursting
sensation. Feels better in open air and needs constant affection.
Silica: Main remedy for constant catarrh, ‘glue ear’. Thick and
purulent discharge. Child bores their finger in their ear.

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22
Q

Causes and risks for childhood anxiety?

A

1) nutritional deficiencies:
* EFAs — deficiency is linked to neuroinflammation, lower
dopamine and reduced neuroplasticity,
myelination sheath functioning. Pre-teens and teenagers are
especially vulnerable to EFA deficiencies due to hormonal
changes and developmental growth requirements.
* Magnesium def. — HPA dysregulation and ↓ monoamine levels.
* Zinc def. — increases cortisol, reduce neuroplasticity,
alters hippocampal synaptic transmission.
* Selenium — thyroid dysregulation and ↑ oxidative stress.
* Vitamin D — alter neurotrophic factors and monoamine levels.
Also consider the role of B vitamins
as NT co-factors

Natural approach:
* Focus on principles of the CNM Naturopathic Diet.
Remove caffeine, sugar, and food additives which
can drive anxiety. Focus on nutrient-dense foods.
* Stabilise blood glucose levels and make sure they are hydrated.
Probiotics and support the gut-brain connection (previous content).
* Address any nutritional deficiencies accordingly.
* Herbal nervines (e.g., chamomile, lemon balm, lavender,
passionflower, ashwagandha) which influence GABA
receptors. Use drop doses in water or dose as herbal
teas 3 x day (adult dose 1 cup) hot or Causes / risk factors:
* Bullying, social media, friendship issues are common.
* Poor teaching at school causing irritability.
* Blood sugar dysregulation (e.g., high refined sugars, poor sleep, etc.)
— associated with hypoglycaemic effects impairing cognition.
* Chronic stress – ↑ cortisol leads to periods of hypoglycaemia and can
result in altered neurotransmitter functioning. Also disrupted sleep

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23
Q

Childhood anxiety natural approaches?

A

Remove caffeine, sugar, and food additives which
can drive anxiety. Focus on nutrient-dense foods.
* Stabilise blood glucose levels and make sure they are hydrated.
Probiotics and support the gut-brain connection (previous content).
* Address any nutritional deficiencies accordingly.
* Herbal nervines (e.g., chamomile, lemon balm, lavender,
passionflower, ashwagandha) which influence GABA
receptors. Use drop doses in water or dose as herbal
teas 3 x day (adult dose 1 cup) hot or cold.

© CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD.
Natural approach — Bach flower remedies:
* Mimulus — shyness and anxiety about something specific.
* Aspen — anxiety but they don’t know why.
* White chestnut — when the mind gets fixed on
a particular thought and they cannot let it go.
* Larch — lack of confidence; convinced they will fail at everything.
* Rock rose — extreme fear / panic. Consumed by anxiety.
Natural approach – other:
* Regular exercise — reduces stress / anxiety, ↑ endorphins. Include
cardio, calming stretching and team sports where applicable.
* Journalling, art or music therapy.
* Time outside in fresh air, green therapy (increases Vagal tone).
41
Childhood Anxiety
Dosage: 4 drops,
4 times a day
Interactions with
animals also ↓ stress
and ↑ oxytocin
(

24
Q

3 considerations of urinary health?

A

Nutritional considerations for kidney health:
* Hydration — essential to allow efficient filtration and elimination.
Include around 1.5–2 litres of filtered water daily (requirements
vary — consider constitution, climate, level of physical activity).
* Moderate salt intake — high salt is linked with immune cell
activation and renal tissue remodelling ↑ risk of kidney disease.
* Avoid high protein diets — ↑ nitrogenous wastes (e.g., urea, creatinine,
uric acid) = ↑ kidney demand. Causes an ↑ in GFR, which can damage
kidney structures over time. Animal protein ↑ risk of kidney damage
more than plant protein. Relates to ↑ acid load, ↑ phosphate and ↑ risk
of disruption to the gut microbiome causing inflammation.

25
Considerations for kidney/ urinary health?
Nutritional considerations for kidney health: * Hydration — essential to allow efficient filtration and elimination. Include around 1.5–2 litres of filtered water daily (requirements vary — consider constitution, climate, level of physical activity). * Moderate salt intake — high salt is linked with immune cell activation and renal tissue remodelling ↑ risk of kidney disease. * Avoid high protein diets — ↑ nitrogenous wastes (e.g., urea, creatinine, uric acid) = ↑ kidney demand. Causes an ↑ in GFR, which can damage kidney structures over time. Animal protein ↑ risk of kidney damage more than plant protein. Relates to ↑ acid load, ↑ phosphate and ↑ risk of disruption to the gut microbiome causing inflammation.
26
Urine colour chart: * Always ask about the colour of urine (first sample of the morning is always darker). * Riboflavin will make urine bright yellow. * Cloudy urine may indicate an infection. * Frothy urine may be due to proteinuria (and renal disease). * Red or pink urine could be due to haematuria or eating beetroot!
27
What is a UTI and what are the signs and symptoms?
UTI = Inflammation due to infection anywhere in the urinary tract, ranging from the distal urethra to the kidney. * UTI in the kidney is called pyelonephritis; in the bladder, cystitis; and in the urethra, urethritis. * Disturbance to the terrain allows microbial overgrowth resulting in infection — usually bacterial. 80 to 90% of UTIs relate to uropathogenic Escherichia coli (UPEC). * Recurrent infections are often associated with Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis or Staphylococcus saprophyticus, secondary to underlying imbalances. 46 (Flores-Mireles et al. 2015) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Key signs and symptoms: * Cystitis: Dysuria, frequent / urgent urination, suprapubic pain / tenderness, foul-smelling / cloudy urine, haematuria, malaise, fever. * Urethritis: Dysuria, urethral discharge (e.g., purulent, blood), pruritis (e.g., in men near the penile opening), change in voiding patterns. * Pyelonephritis: Fever, chills, nausea, malaise, mild to extremely severe ‘loin’ discomfort, blood or pus in urine. May be accompanied by lower urinary tract symptoms. This is a red flag — seek medical attention.
28
Causes/ Risk factors of UTI?
Women (8 x more prevalent) — shorter urethra ↑ the chance of bacteria ascending to the bladder. * Menopause — low oestrogen = ↓ vaginal mucus = ↓ monitoring of bacterial species in the area. * Pregnancy — mechanical pressure of the growing uterus on the ureter and bladder preventing complete voiding. * Sexual activity (in weak terrain) — introduces new bacteria. * Elderly — lowered immunity, decreased mobility, ↓ mucin (protects urinary epithelium), ↓ bacterial adherence, ↑ catheterisation. * BPH — ↑ risk; can obstruct urine flow causing bladder urinary stasis. 48 Urinary Tract Infection (UTI) (Flores-Mireles et al. 2015; Blake, 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Causes and risk factors (cont.): * Antibiotics — increases the likelihood of opportunistic bacteria proliferating and migrating into the urinary tract. The urinary system contains a unique microbiome that protects against infection. * Intestinal dysbiosis — bacteria can translocate from the perianal region and ascend to the genitourinary tract. * ‘Gut-vagina-bladder axis’ — bacterial vaginosis (characterised by ↑ anaerobic bacteria e.g., Gardnerella vaginalis, ↓ Lactobacillus and an alkaline vaginal pH) increases UTI risk. G. vaginalis can ascend into the urinary tract and appears to damage the bladder lining, while reactivating latent E. co
29
Natural approach to UTI?
Antibiotics — increases the likelihood of opportunistic bacteria proliferating and migrating into the urinary tract. The urinary system contains a unique microbiome that protects against infection. * Intestinal dysbiosis — bacteria can translocate from the perianal region and ascend to the genitourinary tract. * ‘Gut-vagina-bladder axis’ — bacterial vaginosis (characterised by ↑ anaerobic bacteria e.g., Gardnerella vaginalis, ↓ Lactobacillus and an alkaline vaginal pH) increases UTI risk. G. vaginalis can ascend into the urinary tract and appears to damage the bladder lining, while reactivating latent E. coli. 49 Urinary Tract Infection (UTI) (Georgieva et al. 2015; JonesFreeman et al. 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Natural approach — avoid / reduce: * Simple sugars and refined carbohydrates: negatively impact the microbiome, increase inflammation and compromise immunity. * Substances that irritate the urinary tract epithelium, in particular caffeine, diet soft drinks and alcohol. * Caffeine and artificial sweeteners — shown to increase detrusor muscle contraction contributing to urinary urgency and frequency. * Red meat, pork and poultry — can act as reservoir for uropathogenic E. coli. Can also promote inflammation (arachidonic acid). 50 Urinary Tract Infection (UTI) Also avoid sexual activity in an acute infection, and body cleaning products that contain irritating chemicals. (Chen et al. 2020) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Natural approach — include: * CNM Naturopathic Diet: Plant-based diets are associated with ↓ incidence of UTIs: phytonutrients are antimicrobial, antioxidant and anti-inflammatory. High fibre content may modulate microbiota, ↓ intestinal pH and prevent growth of E.coli and Enterobacteriaceae. * Prebiotic and probiotic foods — to optimise microbiota colonisation. * Ensure optimal water intake to flush bacteria through the urinary tract (incl. herbal teas). * Cranberry 15–30 ml unsweetened 100% (undiluted) juice daily or 500 mg powder 3x day. Its proanthocyanins ↓ bacterial adhesion to the bladder epithelium. 51 Urinary Tract Infection (UTI) (Chen et al. 2020) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. 52 Urinary Tract Infection (UT
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Supplements for UTI's?
Natural approach – supplements: Nutrient: Functions: D-mannose 500mg every 2 hours for 3– 5 days. * Binds type 1 fimbriae of uropathogenic E.coli, forming a physical ‘coating’ that prevents their binding to the urothelium. * Shows benefit in treatment and prevention of recurrent UTIs. Vitamin A 5000 iu / day. * Maintains integrity of the urinary tract mucous membrane. Plays a role in re-epithelialisation of damaged mucosal surfaces. * Supports lymphatic tissues and immune cells; enhances T cell proliferation. (Scaglione & Minghetti, 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. 53 Nutrient: Functions: Vitamin C 500–5000 mg / day in divided doses. * Has immunostimulatory effects. * Regulates lymphocytes, phagocytes and natural killer cells. * Helps maintain integrity of the uroepithelial lining of the urinary tract. Vitamin D Optimise levels * In response to pathogen exposure, promotes production of anti-microbial substances (notably cathelicidin) in the urinary epithelium. * Strengthens innate mucosal immunity and deters pathogenic bacterial attachment to the uroepithelium. Urinary Tract Infection (UTI) Natural approach — supplements (cont.): Also see immune lecture (Chromek et al. 2006; Gombart et al. 2009) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. 54 Nutrient: Functions: Zinc 15 mg: Preventative. Up to 60 mg during an acute infection. * Increases phagocyte, natural killer cell, T- and B-cell activity. * Increases resistance to infection. Low levels are associated with increased risk of recurrent UTI. Probiotic Lactobacillus spp. As per label dose. Probiotic powder can be smeared directly inside vaginal wall. * Suppress pathogenic colonisation (compete for attachment sites and nutrients). * Modulate the immune system. Includes production of antibacterial agents e.g., lactic acid, hydrogen peroxide and bacteriocins. * Maintain epithelial barrier integrity. Natural approach — supplements (cont.): Urinary Tract Infection (UTI) (Mohsenpour et al. 2019; Jones-Freeman et al. 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. 55 Urinary Tract Infection (UTI) Natural approach — herbal support: * Crataeva (Crataeva nurvala) — a bladder tonic — helps flush the urinary tract, reducing residual urine in which bacteria can flourish. ↓ UT inflammation. Especially indicated for recurrent UTIs. * Bearberry (Arctostaphylos uva-ursi) — anti-inflammatory and a urinary antiseptic (attributed to the urinary metabolite hydroquinone). * Cornsilk (Zea mays) — a mild diuretic and urinary demulcent (soothes mucous membranes of the urinary tract). Infuse dried herb in 500 ml freshly boiled water: 5 g crataeva, 4 g bearberry, 5 g cornsilk. Strain and take ½–1 cup every 2–4 hrs. Not to be used in pregnancy. © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Interstitial cystitis (IC) = a chronic inflammatory c
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What is interstitial cystitis ? Signs and symptoms?
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Causes and risk factors of interstitial cystitis?
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What are urinary calculi?
Urinary calculi = formation of crystalline salts and organic matter in the kidney and bladder (gravel). * May be asymptomatic or cause debilitating pain (renal colic) if a stone lodges in a ureter. Other symptoms: Nausea, vomiting, fever. The main types of stones are: * Calcium oxalate (the most common). * Calcium phosphate. * Uric acid. * Struvite stones — most often caused by chronic bacterial infection (increases alkalinity of urine promoting precipitation of compounds)
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Causes and risk factors for urinary calculi?
Dehydration — urine becomes too concentrated allowing minerals and other compounds to precipitate out of solution, forming crystals. * Altered urinary pH — too acidic = calcium oxalate and uric acid stones; too alkaline = struvite and calcium phosphate stones. * Dietary acid load (animal protein, dairy, soft drinks i.e., phosphoric acid) is the greatest predictor of calcium oxalate and uric acid stones: ‒ ↑ secretion of calcium (oversaturates urine) ‒ ↓ secretion of citrate (needed to solubilise calcium oxalate in urine) ‒ ↑ excretion of uric acid (oversaturates urine). * High table salt intake — increases urinary calcium. 62 Urinary Calculi © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Causes and risk factors (cont.): * Calcium stones are linked to: – A diet low in fibre, high in refined carbohydrates and alcohol. – ↑ Calcium supplementation and possibly a low vitamin K2 status (not storing calcium in bones) — consider a link with dysbiosis. * High intake of oxalate-rich foods (alongside other factors). * Low citrate increases urinary calcium. Can result from excess sodium, low potassium, excessive exercise and acid-forming foods. * High protein intake, especially animal protein, increases uric acid (a by-product of protein metabolism). * Purine-rich foods e.g., organ meats, sardines, chicken (↑ uric acid)
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Natural approach to urinary calculi?
Natural approach: * Increase fluid intake (distilled, filtered water) at least 8 glasses daily. * Alkalise with a plant-based diet high in chlorophyll. Regular green juices / smoothies. * Reduce all animal proteins and high purine foods. * Reduce salt intake (i.e., table salt), avoid alcohol (↑ uric acid). * Increase potassium-rich foods (fruit and vegetables) to reduce urinary calcium. Fruit is also often rich in citrate. * Avoid oxalate-rich foods such as spinach, rhubarb, strawberries, beetroot, almonds and cashews. 64 Urinary Calculi © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Natural approach (cont.): * Magnesium (600 mg / day) as c
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Supplements for urinary calculi?
Natural approach (cont.): * Magnesium (600 mg / day) as citrate — ↑ the solubility of calcium oxalate and ↓ risk of calcium phosphate and calcium oxalate precipitating out of solution. * Pyridoxine (25 mg / day) — reduces endogenous production and urinary excretion of oxalates. * Folate (5 mg / day) — for uric acid stones. ↑ purine scavenging and xanthine oxidase inhibition, resulting in ↓ uric acid production. * Blackcurrant juice is alkalising and can be used for uric acid stones. * Struvite (10–15%) and pure calcium phosphate stones (~5%): use cranberries and betaine-rich foods e.g., beetroot to lower urinary pH. 65 Urinary Calculi © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD. Natural approach (cont.): * Stinging nettle leaf (Urtica dioica) has diuretic properties and is alkalising. Use as a tea: 1 tsp per cup, 3 cups per day. * Combine with demulcent herbs to lubricate the urinary tract (e.g., marshmallow root) * Lemon juice 1 teaspoon every ½ hour for two days can help to soften stones. The citric acid component binds to calcium to promote excretion. * Castor oil packs can be applied to front, sides and back to reduce inflammation and decrease spasm.
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Describe testosterone and the functions, circulations?
Testosterone = a steroid sex hormone under hypothalamic and pituitary gland control. * Produced: In men >95% from the testes by Leydig cells, with the remainder mostly from the adrenals. * Functions: Male sexual characteristics — facial hair, deepening of voice, development of penis and testes, libido and sperm production. Skeletal muscle growth and increases bone density. * Circulation: ~60% is weakly bound to albumin and ~40% tightly bound to SHBG. ‘Free testosterone’ accounts for ~1-2%. ‘Bioavailable testosterone’ = free + albumin-bound testosterone.
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Symptoms and causes/ risk factors of low testosterone?
Low testosterone = the most common type of male sex hormone imbalance (often combined with high oestrogen). * Signs / symptoms: Central weight gain, low energy, low libido, erectile dysfunction, infertility / low sperm count / motility, osteoporosis, hair loss, fatigue, loss of muscle bulk and strength, mood changes. * Causes / risk factors: – Ageing — declines with age after 40 years by ~1% each year. Associated with symptoms referred to as the ‘andropause’. – Chronic stress — cortisol and epinephrine have inhibitory effects on testosterone release. Androgens Low testosterone is also associated with IR and ↑CVD risk (Zheng et al. 2012; Tyagi 69 et al. 2017; NHS, 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. Androgens Low testosterone — causes / risk factors (cont.): * Elevated SHBG ― binding too much testosterone, e.g., medications (metformin, tamoxifen); liver disease and dysfunction ― impaired SHBG detoxification; anorexic states and overtraining. * Thyroid dysfunction ― likely through its effects on SHBG. * Zinc deficiency ― it supports testosterone production. * Increased aromatase activity (e.g., obesity, insulin resistance, excess alcohol; inflammation and ↑ PGE2). * Environmental toxins ― e.g., BPA can bind to androgen receptors. * Sleep deprivation ― testosterone is made mostly during sleep. * Medications ― e.g., opioids (inhibit GnRH).
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Natural approach to low testosterone?
Low testosterone ― natural approach: * Address the cause, e.g., stress support (see stress lecture), weight loss, thyroid support (see endocrine lecture) etc. * CNM Naturopathic Diet with low GI foods, healthy dietary fats (pregnenolone synthesis), zinc-rich foods (testosterone synthesis). * Exercise ― resistance training (e.g., weights) and HIIT ↑ testosterone.* Sleep hygiene; avoid xenoestrogens (see women’s health). * Support liver detox and balance gut microbiome (oestrobolome) ― to ↓ SHBG and oestrogens (see Detoxification + Women’s Health). * Mitochondrial support (e.g., B vitamins, CoQ10, alpha-lipoic acid, Se, glutathione, etc.,) ― pregnenolone is formed in mitochondria.
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Supplements for low testosterone?
Low testosterone ― supplements: 72 Nutrient: Function: Zinc 15‒30 mg / day * Supports testosterone production, and promotes spermatogenesis. Vitamin D Optimise levels * Increases Leydig cell testosterone production and supports a health testosterone / oestradiol ratio. Magnesium 200‒400 mg / day * In combination with zinc and B6 shown to improve testosterone levels in athletes. D-chiro-inositol 600 mcg x 2 / day * Modulates aromatase — ↓ conversion to oestrogens. Also supports cell insulin sensitivity. B complex 50‒150 mg / day * Mitochondrial support (for pregnenolone synthesis). Methylation support (↓ homocysteine and CVD risk). (Maggio et al. 2014; Tyagi et al. 2017; Holt et al. 2020; Monastra et al. 2021; NHS, 2021; Nordio et al. 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. Androgens Low testosterone — herbs: 73 Herb: Function: Ashwagandha (Withania somnifera) 2‒5 g powder/ day * Increases testosterone (and DHEA) by stimulating GnRH production. Might also inhibit aromatase activity. Mucuna pruriens Up to 100 mg / day * ↑ Leydig cell production of testosterone, likely through ↑ dopamine  ↑ GnRH  FSH + LH. Tribulus terrestris 500–650 mg / day * ↑ free testosterone by ↑ LH release. It also ↑ libido, NO synthesis and sperm motility. Shatavari (Asparagus racemosus) Up to 3 g powder / day * Its steroidal glycosides exert testosterone-like effects. Considered an aphrodisiac. Nettle root, fenugreek and maca root also support testosterone levels (Pokrywka et al. 2014; Lopresti et al. 2019) 73 © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. Androgens
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What is DHT, what is is associated with and caused by?
Dihydrotestosterone (DHT): * Produced: From testosterone by 5a-reductase. * Activity: The more potent androgen (approx. 2–5 x stronger than testosterone). It binds more strongly to androgen receptors and does not aromatise into oestrogen. * Increased DHT levels: Associated with acne, male pattern baldness, mood (anger), prostate disorders. * Causes of ↑ 5a-reductase activity: Inflammation (i.e., poor diet gut health etc.,) ↑ insulin, obesity, low zinc status, pesticides, steroid 5-alpha reductase type 2 (SRD5A2) SNP.
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How to lower DHT naturally?
Lowering DHT ― inhibiting 5α-reductase: * Address inflammation (see immune lecture), stabilise blood glucose levels and support insulin sensitivity (see endocrine lecture), reduce adiposity, eat organic. 75 See later section on BPH for more 5a reductase inhibitors Nutrient / herb: Function: Zinc 15–30 mg / day * ↓ 5α-reductase activity, stabilising DHT levels. Saw palmetto (Serenoa serrulata) 500–1000 mg (berry) * Its high levels of beta-sitosterol inhibit 5α-reductase and DHT binding to androgen receptors. Stinging nettles (Urtica dioica) 300–600 mg (root) * Inhibits 5α-reductase and aromatase (reducing DHT and oestrogen); binds to SHBG, increases testosterone.
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What is occasional and frequent erectile dysfunction and what are the causes?
- inability to achieve or maintain an erection firm enough to have sexual intercourse. * ‘Occasional ED’ - experienced during times of stress, anxiety or relationship problems. ‘Frequent ED’ can be a sign of an underlying health problem. Causes / risk factors: * Low testosterone ― * Stress, anxiety ― increases sympathetic NS activity; noradrenaline is the primary ‘anti-erectile’ neurotransmitter. * Dietary — low whole-grain foods, legumes, vegetables, fruits, and high red meats, refined sugars and dairy products are linked to ED. * Diabetes mellitus — associated with ↑ AGEs, ↑ free radicals, impaired nitric oxide synthesis and neuropathic damage. * Medication induced — e.g., β-blockers, anti-depressants, opiates. * CVD — atherosclerosis results in arterial insufficiency (erection occurs after nitric oxide (NO) is released from PSNS nerve fibres) * Neurogenic — deficit in nerve signalling to the corpora cavernosa. E.g., lumbar disc herniation, MS, Parkinson's.
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Natural approach to erectile dysfunction?
Natural approach: * Address the cause, e.g., Diabetes mellitus. * CNM Naturopathic Diet with the focus on phytonutrient-rich plant foods, alcohol elimination and healthy weight management. * Moderate exercise including both cardio and calming exercise (yoga, tai chi) to reduce stress and aid circulation. * In cases of low testosterone, address the underlying cause and see earlier recommendations e.g., Tribulus terrestris. corpora cavernosa = pair of sponge-like regions of erectile tissue in the penis (McKay, 2004; Yafi et al. 2016; Bauer et al. 2020) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. 79 Natural approach — emotional causes (stress, anxiety etc.): * Apply therapeutics as per the Stress lecture (magnesium, vitamin C, B vitamins, L-theanine; solving stress / problems) and Nervous System lecture (B6, passionflower etc.) * Adaptogens — ashwagandha (see earlier), Panax ginseng (1000 mg x 3 daily), Siberian ginseng (100–300 mg x 2 daily). The ginsenosides in ginseng promote NO release. * Bach flowers — mimulus (fear around sexual contact, fear of not being able to perform), larch (loss of confidence in sexual ability), olive (where stress and / or fatigue impact libido), star of Bethlehem (previous traumatic event that contributes to ED). Erectile Dysfunction Bach flowers: 4 drops 4 times daily (McKay, 2004; Kemenov et al. 2017; Lee et al. 2017; Bauer et al. 2020) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. 80 Natural approach (cont.): * Support CV health (see CV lecture). To support penile blood flow include circulatory stimulants, e.g., ginger, rosemary, cayenne. * Beetroot juice / powder (5–10 g) to increase NO production
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Supplements for erectile dysfunction?
Arginine 1500–5000 mg / day * For NO production  vasodilation. Low L-arginine levels have been recorded in men with severe ED. Vitamin D Optimise levels * Regulates NO synthesis by mediating eNOS; vascular protective — for endothelial health. Ginkgo biloba 60‒120 mg x 2 / day * Improves blood circulation by antagonising ‘platelet activating factor’ — causing vasodilation.
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What is Benign Prostatic Hyperplasia and signs and symptoms?
Benign Prostatic Hyperplasia (BPH) = enlargement of the prostate without the presence of malignancy. * Affects approximately 40% of men over the age of 50 and 90% over the age of 90. * Signs / symptoms: Urinary frequency, urgency, hesitancy, nocturia, incomplete evacuation, terminal dribbling
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What are the diagnostics for BPA?
Prostate diagnostics: Digital rectal examination (DRE), prostate specific antigen (PSA) blood test, ultrasound, and biopsy. ‒ PSA blood test: A raised PSA indicates possible prostate enlargement or inflammation. It is normally used as a screen for prostate cancer. Levels >4.0 ng / ml “require investigating”
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What is the aetiology of BPH?
Aetiology: * Whilst DHT is required for normal prostate function, higher levels can cause pathologic prostate growth in adult men. * See earlier causes of raised DHT — e.g., obesity, IR, inflammation, excess alcohol, low zinc status etc. * High stress (↑ SNS activity)  ↑ norepinephrine stimulation of α-adrenoceptors on prostate smooth muscle cells  smooth muscle hyperplasia. * A higher ratio of oestrogens to testosterone. Oestrogens ↑ prostate growth. Declining testosterone >40 years of age can heighten the affect of oestrogens and xenoestrogens on prostate tissue. The prostate is a zinc-rich gland (Carson,
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Natural approach to BPH?
Natural approach: * CNM Naturopathic Diet with a focus on zinc-rich foods (5α-reductase inhibitor) and organic foods (avoiding 5α-reductase promoting pesticides). * See earlier section on lowering DHT (e.g., zinc, saw palmetto, nettle). Note: Zinc has been found to correct mitochondrial apoptosis, thus affecting growth / differentiation of prostate tissue. * Optimise body weight; address stress (see Stress lecture) to reduce SNS activity; Vagal stimulation (see Nervous System lecture). * Remove alcohol, caffeine, artificial sweeteners and fizzy drinks which can irritate the bladder and make urinary symptoms worse. (Wolin et al. 2015; Das & Buchholz, 2019) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. 84 Benign Prostatic Hyperplasia Natural approach (cont.): * Include a rainbow of plant foods. Many polyphenols inhibit 5αreductase activity, reduce inflammation and oxidative stress, e.g.: ‒ Lycopene — inhibits 5α-reductase and interleukin-6 signalling. As little as 2 tsp of tomato paste may prevent cell proliferation and remodelling in the prostate. Ideal dose: 15 mg / day (2 tbsp). ‒ Epigallocatechin gallate — green tea. ‒ Lignans — flaxseeds, sesame seeds. ‒ Daidzein — fermented soya beans. ‒ Kaempferol — apples, broccoli, onions, tomatoes. ‒ Fisetin — strawberries, apples, grapes. (Schwarz et al. 2008; Morgia et al. 2014; Wolin et al. 2015; Eleazu, 2017; Cicero et al. 2019) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. 85 Benign Prostatic Hyperplasia Natural approach (cont.): * Reduce excess oestrogens (see Women’s Health) — ↓ xenoestrogens (e.g., BPA), aromatase inhibitors (e.g., flavonoids, white button mushroom, inositol), phase I and II detox support (e.g., I3C, methylation), bowel clearance (e.g., fibre, 5R / probiotics). * Beta-sitosterol (60‒130 mg / day) improves urinary symptoms and flow in BPH (found in pumpkin seeds, saw palmetto, nettle root). It inhibits 5α-reductase and aromatase. * Physical activity — there is an inverse association between this and BPH. It has been shown to improve nocturia in BPH. Tissue salts (1 each x 4 daily): Calc fluor 6x, Nat. mur. 6x, Nat. sulph. 6x, Mag. phos. 6x. (Wolin et al. 2015; Pizzorno et al. 2016; Cicero et al. 2019) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. 86 Benign Prostatic Hyperplasi
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Nutrients for BPH?
Nutrient / herb: Function: Selenium 200–600 mcg * An essential component in the antioxidant glutathione peroxidase. ↓ hyperplasia, PSA levels and irregularities in the prostate nuclei. Reishi 3–9 g / day * Shown to inhibit 5α-reductase and reduce PSA levels. Vitamin D Optimise levels * Shown to decrease prostate cell proliferation (especially when induced by DHT, Il-8 and IGF-1). Anti-inflammatory — inhibits COX-2 and PGE2. Berberine 50–250 mg / day * ↓ prostatic hyperplasia in BPH by inhibiting 5α-reductase, ‘extracellular signal-regulated kinase’ (ERK) and NF-κB.
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Signs and symptoms of prostate cancer?
Signs / symptoms: Same as BPH with addition of haematuria, blood in the ejaculate, pain on ejaculation, back pain (possible spinal metastases).
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Risk factors for prostate cancer?
Risk factors: * Dietary — processed meats, high refined sugar, low fibre, caffeine, high saturated and trans fats increase the risk of prostate hormonal dysregulation, oxidative stress and inflammation as well as altering lipid metabolism and growth signalling. Dairy products (↑ IGF-1). * Abdominal obesity (see Obesity Lecture for causes) — ↑ insulin resistance, chronic inflammation and dysregulated sex hormones. (Gathirua-Mwangi & Zhang, 2014; Cao & Giovannucci, 2016; Harrison et al. 2017; Allemailem et al. 2021; Oczkowski et al. 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. Prostate Cancer 88 Risk factors (cont.): * Poor methylation (e.g., due to lack of key nutrients, COMT SNP) — ↑ 4-OH-E (CYP1B1) activity and quinone formation which cause oxidative damage to DNA. Also consider a low antioxidant status. * Increased 5α-reductase activity  ↑ DHT (see earlier). * GIT ― intestinal dysbiosis can ↑ β-glucuronidase  raised circulating oestrogens.  cell proliferation. An impaired intestinal barrier can result in chronic low-grade inflammation. * Nutrient deficiencies / insufficiencies; e.g., Zn, Se, vit. D (see later). * SNPs e.g., CYP3A4 polymorphism (CYP3A4 enzyme is associated with oxidative deactivation of testosterone).
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Nutrients for prostate cancer
CNM Naturopathic Diet (e.g., remove dairy) with a focus on zinc and selenium-rich foods. A Mediterranean style diet has been shown to prolong prostate cancer survival rates when coupled with exercise. * Quercetin, resveratrol, EGCG and curcumin increase both intestinal and prostate zinc absorption rates. * Lycopene (2 tbsp tomato purée daily) — induces apoptosis and blocks the intercellular gap junction communications responsible for the invasion and metastasis of prostate cancer. * Support as needed (see respective lectures): Methylation, detox / elimination pathways, weight, intestinal microbiome and barrier. More information on cancer support in the Cancer lecture (Del Buono et al. 2016; Qu et al. 2017; Di Maso et al. 2020; Mirahmadi et al. 2020; Palomar-Cros et al. 2021; Schumacher et al. 2021; Singh et al. 2021; Kang et al. 2021; Wang et al. 2021) © CNM: Nutrition Year 2 ― Paediatrics, Urinary Health & Men’s Health. RD/BQ. Prostate Cancer 90 Natural approach (cont.): Nutrient/Herb: Function: Zinc 15–30 mg / day * Anti-carcinogenic ― stabilises DNA and RNA; inhibits prostate cancer cell line growth and invasion. Inhibits NF-κB. ↓ DHT. Selenium 200–600 mcg * Increases glutathione peroxidase; low levels are linked to carcinogenesis (and prostate cancer). Vitamin D Optimise levels * Antiproliferative activity. It can cause apoptosis, inhibit tumor cell invasiveness and suppress tumour-induced angiogenesis. Reishi 3–9 g / day * Its triterpenes suppress the migration and invasion of prostate cancer cells and induce apoptosis by inhibiting matrix metalloproteinase (MMP) expression. Shiitake 1.5–10 g / day * The beta-glucan lentinan has anti-proliferative and anti-angiogenic properties.
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What is prostatitis? Signs and symptoms?
Prostatitis = inflammation of the prostate with or without infection. * Signs / symptoms: Similar to BPH with the addition of frequent UTIs, dysuria, blood in the urine or semen, discharge from the urethra, pain on ejaculation; pain around male genitalia, anus, lower abdomen and lower back; fever and malaise. *
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NAtural approach to prostatitis
Natural approach: Address the cause! * CNM Naturopathic Diet with a focus on reducing inflammation and immune support in infective cases (see Immune lecture). – EFAs, turmeric, ginger and vitamin C are PGE2 inhibitors and reduce inflammation in prostatitis. * Zinc, selenium, lycopene, saw palmetto and stinging nettle for prostate support (see earlier). * Quercetin (500–1000 mg x 2 daily) — shown to reduce prostatic inflammation. Inhibits LOX, COX and NF-κB. * Probiotics and prebiotics to increase microbial diversity and anti-inflammatory Prevotella which are often low in the gut microbiota of those with prostatitis.
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Aeitiology of prosattitis?
Aetiology: Chronic low-grade inflammation and low immune function (see Immune lecture). Links with low testosterone (see earlier). Genitourinary dysbiosis (proinflammatory bacteria such as E.coli, Streptococcus anginosus and Propionibacterium acnes are associated with infective prostatitis), as well as STDs (e.g., chlamydia).