paeds essential conditions Flashcards
(200 cards)
How is bilirubin formed?
What % of term babies develop jaundice in first week of life?
What’s the difference between conjugated and unconjugated bilirubin?
Formation of Bilirubin:
Red blood cells –> Haem broken down —> Bilirubin = transported to liver as unconjugated bilirubin, bound to albumin—> conjugation in the liver = become water soluble —> conjugated bilirubin excreted in the bile into duodenum —> stercobilinogen = makes faeces brown
60% term babies develop jaundice in first week of life
Usually unconjugated cause (pre-hepatic) – conjugated would indicate a worrying post hepatic cause
DDx for neonatal jaundice:
< 24 hrs
- unconjugated? 2
- conjugated? 4
24hrs - 2 wks
- unconjugated? 3
- conjugated? 4
> 2 wks
- unconjugated? 4
- conjugated? 3
nb unconjugated is much more common!!
< 24 hrs UNCONJUGATED
- haemolytic disease (eg rhesus, HBO incompatibility, hereditary spherocytosis, G6PD deficiency)
- neonatal sepsis
< 24 hrs CONJUGATED (ie neonatal hepatitis)
- hepatitis A or B (also a1-antitrypsin)
- TORCH infections
- Inborn errors of metabolism (eg galactosaemia)
- CF
24hrs - 2wks UNCONJUGATED
- PHYSIOLOGICAL
- hypothyroidism
- haemolysis/sepsis
24hrs - 2wks CONJUGATED
- (as above - ie hep, torch, metabolism, CF)
> 2wks UNCONJUGATED
- breast milk jaundice (but should have resolved by now)
- haemolysis
- sepsis
- hypothyroidism
> 2wks CONJUGATED
- BILIARY ATRESIA
- choledochal cyst
- neonatal hepatitis
JAUNDICE IN FIRST 24hrs IS NEVER PHYSIOLOGICAL!
PHYSIOLOGICAL JAUNDICE:
- when does it appear? and when should it go by?
- pathophysiology?
- what four things exacerbate it? 4
Appears after 24hrs, peaks day 3-4
Usually self-resolving by 14 days
Presents and progresses in cephalic to caudal direction
Immaturity of hepatic bilirubin conjugation process
Breakdown of foetal haemoglobin
EXACERBATED BY:
- bruising (eg forceps)
- polycythaemia
- dehydration (eg caused by poor feeding)
- prematurity
Give four examples of haemolytic disorders which can result in neonatal jaundice? (briefly describe each)
What blood test is done to rule these out?
RHESUS-HAEMOLYTIC DISEASE: affected infants are usually identified antenatally and monitored and treated when necessary. If not identified early then children can be born with anaemia, hydrops and hepatosplenomegaly
ABO INCOMPATIBILITY: now more common than rhesus disease. Most ABO abs are IgM and so do not cross the placenta but some women who are group O have IgG abs which can cross the placenta and start breaking down the red cells of the group A infant. The jaundice can be striking but there are usually fewer other severe symptoms in ABO compared to RHESUS
G6PD DEFICIENCY - develop haemolytic anaemia and jaundice. Mainly affects male infants
HEREDITARY SPHEROCYTOSIS
tests for haemolytic antibodies should be done - COOMB’S TEST
NEONATAL JAUNDICE Hx
- most important question? (and two red flag answers to this)
- prenatal Qs to ask? 2
- Qs to ask about labour? 7 (which 3 of these are risk factors for neonatal sepsis)
- Qs to ask about post-natal? 6 (incl feeding, bowels etc)
- conditions to ask if FHx of? 2
- other FHx to ask? 2
AT WHAT AGE DID THE JAUNDICE DEVELOP?
- <24hrs = red flag
- > 2wks = red flag
PRENATAL
- full antenatal care received? (if not may have missed rhesus or other screening etc)
- get any infections in pregnancy? (or in contact with anyone - list torch)
INTRAPARTUM
- gestation born?
- method of delivery?
- any trauma to baby during delivery? (bruising/forceps etc)
- how long mebranes ruptured for? (>12hrs sepsis)
- any fever? (sepsis)
- any high foetal HR? (sepsis)
- have to stay in NICU for any period?
POST NATAL
- general behaviour (active/alert or lethargic/needing to be woken)
- how fed? (breast or bottle)
- any feeding difficulties?
- when pass meconium (>48 hrs could be CF)
- How stools been since (pale, chalky = red flag for biliary atresia)
- wet nappies (lack of could mean infection/dehydration)
FHx
- any previous children (any problems)
- cosanguinity? (inborm errors)
- CF
- spherocytosis
Exam for NEONATAL JAUNDICE:
- what looking for? 10
nb you effectively do a full NIPE exam! (maybe minus the hips)
- is baby alert / well
- how handle / tone (hypothyroid)
- extent of jaundice (norm spreads from head towards feet)
- does it blanch to pressure? (hard to see if non-white)
ANY SIGNS OF DEHYDRATION
- mucous membranes
- dry nappy
- sunken FONTANELLE)
ANY FEATURES OF TORCH
- petechiae
- anaemia
- hepatosplenomegaly
Investigations for neonatal jaundice:
- initial test for all?
- initial bloods? 4
- other tests to consider to help find cause? 4
- what further tests should be done if infant still jaundiced after 14 days? 2
Measure trans-cutaneous bilirubin
if high, need to find cause:
- FBC (shows anaemia, low or high WCC)
- LFTs (esp proportion conjugated or not)
- Group + save (compare w mothers)
- COOMBS TEST
OTHER TESTS
- TORCH screen
- Septic screen
- TFTs
- Urine metabolic scvreen (inborn errors)
IF STILL JAUNDICE AFTER 14 DAYS (look for biliary atresia)
- liver USS
- liver isotope scan
NEONATAL JAUNDICE:
- three symptomatic management options? when use each?
- what other management is needed?
1) DO NOTHING
- if unconjugated bilirubin is lower than line for phototherapy
- reasssure parents that it is self-limiting AND safety net
- encourage feeding if struggling
2) PHOTOTHERAPY
- if unconjugated bilirubin above line for phototherapy
- baby lies under UV light with eyes protected
- have breaks for feeding, changing nappies etc
- measure bilirubin every 4-6 hours during phototherapy
- stop phototherapy once levels of bilirubin have dropped to at least 50micromol/L below threshold for treatment
3) EXCHANGE TRANSFUSION
- if unconjugated bilirubin above line for exchange transfusion (though can try phototherapy first)
REMEMBER JAUNDICE <24hrs is ALWAYS pathological and needs further investigation
FIND AND TREAT UNDERLYING CAUSE!
- unless just physiological!
BILIARY ATRESIA
- what is it?
- management? 1
GALACTOSAEMIA:
- what it it?
- absence of intra or extra hepatic bile ducts
- causes conjugated hyperbilirubinaemia
- stool becomes clay coloured
- leads to liver failure and death
Kasai procedure within 6 weeks of life can achieve adequate biliary drainage
GALACTOSAEMIA
means you can’t break down galactose
can cause neonatal hepatitis and jaundice
nb these conditons have nothing to do with each other (except that they both cause jaundice) they’re just on the same card because I accidently deleted one
an inborn error of metabolism
What is the complication that can occur if there are high levels of unconjugated bilirubin in the neonate?
specific form of brain injury known as KERNICTERUS
This occurs because babies have very thin blood-brain barriers that are not that efficient at keeping things out (this is also why they are more prone to meningitis). As a result of this the high levels of unconjugated bilirubin in their blood crosses this barrier readily - the unconjugated bilirubin collect in the basal ganglia
This bilirubin can damage the brain and the spinal cord and this can be life-threatening for the baby
Initial symptoms
- Poor feeding
- Irritability
- High-pitched cry
- Lethargy
- Apnoea
- Hypotonia
- Seizures - late sign
- Muscle spasms - late sign
Child can go on to develop cerebral palsy, learning difficulties and hearing problems
nb this is very rare now as most jaundice is picked up
What vaccinations are babies given at:
- 8 weeks? 3
- 12 weeks? 3
- 16 weeks? 3
- 1 year? 4
- 2 years? 1
- 3yrs 4mnths? 2
- 12-13 years? 1
- 14 years? 3
nb number refers to the number of injections - some vaccines cover more than one infection - list these if applicable
8 WEEKS
- diptheria, tetanus, pertussis, polio, haem influenzae type B (HiB), hep B (6-in-1)
- rota virus (oral)
- Meningitis B
12 WEEKS
- pneumococcal
- 6-in-1 (2nd dose)
- rotavirus (oral) (2nd dose)
16 WEEKS
- 6-in-1 (3rd dose)
- Men B (2nd dose)
ONE YEAR
- Hib/Men C (1st dose)
- MMR (1st dose)
- pneumococcal (2nd dose)
- Men B (3rd dose)
2 YEARS
- flu vaccine (nasal) given EVERY year
3 YEARS 4 MONTHS
- MMR (2nd dose)
- 4-in-1 preschool booster (diptheria, tetanus, pertussis + polio)
12-13 YEARS
- HPV vaccine (1st dose)
14 YEARS
- HPV vaccine (2nd dose, 6-12 mnths after 1st)
- 3-in-1 teenage booster (tetanus, diptheria, polio)
- Meningococcal group A, C, W and Y disease (MenACWY)
nb injections are generally given in thigh up to 12mnths then generally arm older than that
nb don’t use alcowipes to wipe skin before immunisations!! as may affect vaccines
What additional vaccines should be offered to infants / children at risk?
when give?
Heb B (at birth)
BCG (any age from birth - 16yrs)
Which common vaccines are live attenuated? 4
other live attenuated vaccines? 3
who should these NOT be given to?
- rotavirus
- MMR
- intranasal influenza
- BCG
- oral polio
- oral typhoid
- yellow fever
SHOULD NOT BE GVEN IF IMMUNOCOMPROMISED
General contraindications to any childhood vaccines? 5
- if younger than schedule
- acutely unwell with fever
- has had anaphylactic reaction to previous dose
- undiagnosed neurodevelopmental condition
- live attenuated vaccines to immunocompromised
also if severe egg allergy, give certain immunisations (esp MMR) under controlled conditions
How is consent taken to give childhood vaccines?
where are childhood vaccines recorded?
written consent is taken at beginning of new schedule
- then verbal consent before each vaccine
record in red book
- record serial number and site of each injection
What diseases are covered in the 6-in-1 vaccine?
- common side effects? 4
- rare side effects? 2
- diptheria
- tetanus
- pertussis
- polio
- haem influenzae type B (HiB)
- hep B
COMMON
- swelling
- redness
- papule at site
- fever
RARE
- febrile convulsions
- anaphylaxis
MMR
- contraindications? 4
- side effect? 3
CONTRAINDICATIONS
- immunocompromised children (is live vaccine)
- pregnant girls
- children with neurological conditions
- severe egg allergy
SIDE EFFECTS
- rash
- fever in 5-10 days
- mild mumps at 14 days
What do these vaccine abbreviations stand for:
- DTaP
- IPV
- HiB
- Td
- DTaP = diptheria, tetanus, acellular pertussis
- IPV = inactivated polio vaccine
- HiB = Haemophilus influenzae type B
- Td = tetanus and diptheria
Causative organisms in meningitis in:
- neonates? 3
- infants / children? 4
- adolescents / adults? 2
NEONATES (ie first 4 wks)
- group B strep
- e. coli
- listeria
INFANTS / CHILDREN
- haemophilus influenzae
- neisseria meningitis
- strep pneumoniae
- viral
ADOLESCENTS / ADULTS
- neisseria meningitis
- strep pneumoniae
MENINGITIS IN NEONATES
- changes in vital signs? 3
- other symptoms/signs? 7
VITAL SIGNS
- fever
- low HR
- high BP
OTHER SIGNS
- irritable
- poor feeding
- lethargy / coma
- seizures (30%)
- respiratory distress
- bulging fontanelle (often meningococcal)
- non-blanching rash (meningococcal)
DO NOT GET CLASSICAL SIGNS OF MENINGISM (have a LOW threshold of suspision)
MENINGITIS IN INFANTS / CHILDREN
- signs of meningism? 3
- other symptoms? 4
- other signs/obs? 5
- clinical signs? (two, which is which)
- fever
- headache
- neck stiffness
^ from 2 years old
OTHER SYMPTOMS
- refusing food
- lethargy
- unsettled
- nausea + vomiting
OTHER SIGNS
- cold peripheries
- non-blanching rash (meningococcal)
- reduced GCS
- high BP
- low HR
CLINICAL SIGNS
Kernig’s sign (K for Knee)
= bend knee up and then extend knee -> pain / resistance
Brudzinski’s sign
= flex pt neck and then hips + knee will flex in response
^ both very specific and sensitive
MENINGITIS IN ADOLESCENTS / ADULTS
- Symptoms / signs? 7
- clinical signs? (two, which is which)
- fever
- headache
- neck stiffness
- photophobia
- muscle aches
- nausea + vomiting
- non-blanching rash (meningococcal)
CLINICAL SIGNS
Kernig’s sign (K for Knee)
= bend knee up and then extend knee -> pain / resistance
Brudzinski’s sign
= flex pt neck and then hips + knee will flex in response
^ both very specific and sensitive
If suspect meningococcal meningitis in community, what do you do immediately? (what to do if allergy?) and within how long?
Give IM BenPen IMMEDIATELY (within 30mins)
- if pen allergic, ceftriaxone
transfer to hospital immediately
Investigations for suspected meningitis:
- bedside? 2
- bloods? 9
- imaging? 1
lumbar puncture (unless CI)
urine analysis
bloods:
- FBC
- U+E
- LFT
- clotting
- CRP
- Blood cultures
- whole blood PCR
- Glucose (do compare w LP)
- VBG
CXR