PAGES 47

Question 1

<5% binucleated cells, with internuclear chromatin bridges (

Answer 1

CDA I

Question 2

CDA 1 is positive to?

Answer 2

FEULGEN

Question 3

CDA II is positive to

Answer 3

HEMPAS

Question 4

presence of gigantoblasts

Answer 4

CDA III

Question 5

10-35% binucleated cells,

Answer 5

CDA II

Question 6

cells that secrete intrinsic factor

Answer 6

Parietal cells

Question 7

Is an autoimmune disorder characterized by impaired absorption of vitamin B 12because of an intrinsic factor deficiency

Associated with Lymphocyte-mediated destruction of gastric parietal cells and autoantibodies to parietal cells (anti-parietal cell antibodies); also anti-IF antibodies

Answer 7

Pernicious anemia

Question 8

Pronounced multinuclearity: up to 12 nuclei per cell; 50-60 um in diameter

Answer 8

Gigantoblast

Question 9

portions of the intestines that are stenotic as a result of surgery or inflammation can become overgrown by bacteria

Answer 9

Blind loop sydrome

Question 10

Inherited disorders of vitamin B12 absorption and transport

Answer 10

Imerslund-Gräsbeck syndrome and Transcobalamin deficiency

Question 11

gluten-induced enteropathy)

Answer 11

Sprue/Tropical sprue and Celiac disease

Question 12

Normoblasts in the bone marrow show multinuclearity, karyorrhexis causing dyserythropoiesis

Associated with refractory anemia and ineffective erythropoiesis, and binucleated cells

Answer 12

Megaloblastic anemia

Question 13

Occurs through the kidneys ; dialysis patients

Answer 13

Excessive loss of folate

Question 14

Methotrexate, 5-fluorouracil, Hydroxyurea, Pyrimethamine, Pentamidine, Trimethoprim

Answer 14

Impair folate metabolism

Question 15

Metformin, Cholestyramine, Birth-control pills, Penicillins, Phenytoin

Answer 15

Impair folate absorption

Question 16

numbness of the fingers of the extremities)

Answer 16

Paresthesias

Question 17

CNS abnormalities

Answer 17

Megaloblastic madness (Severe vitamin B 12def)

Question 18

Increased MCV (>120 fL), Increased MCH, Normal MCHC, Decreased Hgb (7-8 g/dL) and hematocrit, reticulocytopenia

Answer 18

Pancytopenia

Question 19

Measures radioactive vitamin B 12 in the urine

Answer 19

Schilling’s test

Question 20

Increased in both Vitamin B 9 and B 12 deficiency

Answer 20

Homocysteine

Question 21

Vitamin B 9 deficiency - Normal
Vitamin B 12 deficiency - Decreased

Answer 21

Methylmalonic acid (MMA)

Question 22

Antibodies to intrinsic factor and parietal cells

Answer 22

Antibody assays

Question 23

Decreased in Vitamin B 12 deficiency

Answer 23

Holotranscobalamin assay