Paget's Disease of the Nipple

Question 1

What is Paget’s disease of the nipple?

Answer 1

Involvement of epidermis by malignant ductal carcinoma cells

Question 2

What are the clinical features of Paget’s disease of the nipple?

Answer 2

Itching/redness around nipple
Flaking/thickened skin
Painful area
Flattened nipple
Yellow/bloody nipple discharge

Question 3

Differential diagnoses for Paget’s disease of the nipple

Answer 3

Dermatitis

Eczema - can be differentiated by the fact that eczema usually spares the nipple

Question 4

Investigations for suspected Paget’s disease of the nipple

Answer 4

Biopsy

Question 5

Management of Paget’s disease of the nipple

Answer 5

Surgery - depends on underlying breast cancer

Radiotherapy may also be necessary