PAIN + INFLAMMATION Flashcards
(12 cards)
1
Q
what is used for pain related to inflammation
rheumatoid arthritis, back pain, soft tissue disorder
A
NSAID = analgesic + anti-inflammatory
2
Q
NSAIDs CI
A
- asthmatics
- MHRA = risk to foetal growth with prescribing NSAIDs from 20th week of pregnancy
3
Q
COX-2 selective inhibitors
A
- celecoxib
- etroicoxib
4
Q
NSAIDs cautions
A
- low dose aspirin = inc GI bleed risk (only use if needed)
- alcohol = inc GI bleed risk
5
Q
what is given with NSAIDs
A
PPI as stomach protection
6
Q
s.e of NSAID
A
- hypersenstivity reactions
- cross sensitivity with aspirin
7
Q
when to avoid NSAIDs
A
- renal impairment (risk of fluid retention and further impairment)
- avoid in pregnancy (caution in breastfeeding)
8
Q
NSAIDs high risk level
GI and cardiovascular s/e
A
GI S/E
- piroxicam
- ketorolac
- ketoprofen
Cardiovascular S/E
- COX2 selective inhibitors
9
Q
NSAIDs medium risk level
GI s/e
A
GI S/E
- indometacin
- diclofenac
- naproxen
10
Q
NSAIDs low risk level
GI and cardiovascular s/e
A
GI S/E
- ibuprofen
Cardiovascular S/E
- naproxen
- ibuprofen 2.4g
11
Q
NSAIDs lowest risk level
GI s/e
A
GI S/E
- cox-2 selective inhibitors
12
Q
NSAIDs interactions
A
- MTX/lithium - reduces clearance
- ciprofloxacin - inc risk of seizures
- blood thinners - high risk of bleeding
- drugs cause hyperkalaemia
- drugs cause renal failure = AKI
