Palliative Flashcards

(43 cards)

1
Q

Types of pain

A

Nociceptive
- normal nervous system identifiable lesion causing tissue damage
- somatic - originates from skin/muscles/bone
- visceral - viscus or solid organ
Neuropathic
- malfunctioning nervous system
- nerve structure damaged

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2
Q

Description of types of pain

A

Nociceptive
- somatic - sharp, throbbing, well localised
- visceral - diffuse ache, difficult to localise
Neuropathic
- stabbing, shooting, burning, stinging, numbness

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3
Q

Who analgesic ladder

A

1
- non-opioid +/- adjuvant
2
- opioid for mild to moderate pain +/- non-opioid and adjuvant
3
- opioid for moderate to severe pain +/- non-opioid and adjuvant

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4
Q

Analgesics on WHO ladder

A
Step 1
- paracetamol
- aspirin
- NSAIDs
Step 2
- co-codamol
- codeine phosphate
- tramadol
- dihydrocodeine
Step 3
- fentanyl
- diamorphine
- buprenorphine
- oxycodiene
- methadone
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5
Q

NSAIDs and COX2 inhibitors

A
No CV or GI risk 
- ibuprofen
- diclofenac
- naproxen
GI risk but CV risk
- COX2 - celecoxib
CV risk but less GI risk
- naproxen 
- ibuprofen
Prescribe PPI for all
HF exacerbated by all NSAIDS
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6
Q

Adjuvants for pain relief

A
Antidepressants
- amitriptyline
- duloxetine
Anti-convulsant
- gabapentin
- pregabalin
Benzodiazepines
- diazepam
- clonazepam
Steroids
- dexamthasone
Bisphosphates and radiotherapy for bony pain
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7
Q

Side effects of amitriptyline

A

Confusion

Hypotension

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8
Q

Side effects of gabapentin

A

Sedation
Tremor
Confusion
Dizziness

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9
Q

WHO principles of pain relief

A
By the mouth
By the clock
By the ladder
Individual dose titration
Use of adjuvants at any step
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10
Q

Common side effects of opioids

A

Constipation
Dry mouth
N+V
Drowsiness/sedation

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11
Q

Dos for opioid prescription

A

Write up laxative and anti-emetic

- laxido and metoclopramide

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12
Q

Features of opioid toxicity

A

Pinpoint pupils, hallucinations, vomiting, confusion, myoclonic jerks and resp depression
Uncommon when following prescribing guidance
Can occur if dose escalated too quickly or AKI/renal impairment

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13
Q

Stepping up from maximum dose codeine

A

Codeine : morphine is 10:1
240mg codeine equates to 24mg of morphine
Total daily dose morphine = 24mg
Generally prescribe
- morphine SR 15mg BD plus morphine IR 5 mg PRN

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14
Q

How to calculate further titration of opioid dose

A

Add up 24 hours worth of morphine = total daily dose (TDD)
TDD/2 = new morphine SR dose
TDD/6 = new morphine IR PRN dose

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15
Q

When to titrate up opioid dose

A

Consistently needing PRN doses over at least 3/7

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16
Q

SC vs oral morphine

A

10mg SC morphine = 20mg oral morphine

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17
Q

How to write controlled drug prescription

A

Name and ID of patient
Write prescription as normal
Write supply and give pharmacist exact instructions
- drug name and formulation
- total number of tables or amount of drugs in words and figures
Morphine SR (Zomorph) capsules 10mg - supply 56 (fifty six) 10mg tablets
Oramorph oral liquid 10mg/5ml - supply 1 (one) 300ml bottle

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18
Q

Features of fentanyl patches

A

25 micrograms/hour - apply every 3 days

Approx 90mg morphine per 24 hours

19
Q

Causes of N+V

A
Infection
Metabolic
- renal impairment
- hepatic impairment
- low Na
- high Ca
- tumour toxins
Drug related
- opioid
- diuretics
Gastric stasis
- pyloric stenosis
- acites
- hepatomegaly
- opioids
GI disturbance
- constipation
- gastritis
- ulceration
Organ damage
- distension
- obstruction
- RT
Neurological
- raised ICP
- motion sickness
- meningeal disease
Psychological
- anxiety/fear
20
Q

Features of chemical nausea

A
Persistent severe nausea
Unrelieved by vomiting
Aggravated by sight/smell of food
Drowsiness and confusion
Tx = HALOPERIDOL
21
Q

Features of gastric stasis nausea

A
Fullness/regurgitation
Reduced appetite
Vomiting - often large volume and relieve nausea
Epigastric discomfort
Hiccups
Tx = METOCLOPRAMIDE or DOMPERIDONE
22
Q

Features of bowel obstruction nausea

A
High 
- regurgitation
- forceful vomiting of undigested food
Low
- colicky pain
- large faeculent vomits
- visible peristalsis
Tx = CYCLIZINE or DEXAMETHASONE
23
Q

Features of raised ICP nausea

A
Nausea worse in morning
Projectile vomiting
Worse on head movement
Headache
Tx = CYCLIZINE or DEXAMTHASONE
24
Q

Features of psychological nausea

A

Anxiety
Fear
Anticipation
Tx = NON-DRUG or BENZODIAZEPINES

25
Features of post op/RT nausea
Serotonin release | Tx = ONDANSETRON
26
Features of constipation nausea
Nausea Faeculent vomiting Abdominal distension Tx = PROKINETIC or LAXATIVES
27
Risk factors for chemotherapy induced nausea and vomiting (CINV)
Specific chemo agents Female Age < 50 Past Hx of N+V
28
Features of Aprepitant
Prevent CINV NK1 antagonist - acts centrally Augments 5HT3 and dexamethasone SE = constipation and headache
29
Causes of consipation
``` Disease related - immobility - reduced food-intake/low residue diet - intra-abdominal and pelvic disease Fluid depletion - poor fluid intake - increased fluid loss - vomiting, sweating, fistulae, exudating wounds Weakness - inability to raise intra-abdominal pressure Intestinal obstruction Medication - opioids - diuretics - phenothiazines - anti-cholinergic drugs - recent surgery Biochemical - hypercalcaemia - hypokalaemia ```
30
Laxative in oncology
``` Stimulant - senna, bisacodyl - reduce bowel transit time Softener - docusate - increase water penetration of stool Stimulant - sodium picosulfate Osmotic - lactulose, movicol, laxido - can cause flatulence and bloating - need to drink reasonable volume of water Suppositories - glycerin - softner - bisacodyl - stimulant ```
31
Clinical features of bowel obstruction
``` Colicky pain Vomiting Nausea Abdominal distention Anorexia Bowel sounds increased Overflow diarrhoea Constipation Continuous pain Dry mouth ```
32
Mx of bowel obstruction
``` Chemo Stent Surgery Gastrostomy NG drainage ```
33
Causes of breathlessness
Anaemia - transfusion PE - LMWH CCF - diuretics, ACEi COPD - bronchodilators Respiratory tract infection - abx Pleural effusion - aspiration, pleurodesis Pericardial effusion - paracentesis, corticosteroids SVCO - stent, RV, steroids Anxiety - CBT, relaxation, benzodiazepines, SSRIs
34
Neurophysiology of breathlessness
Mismatch between patient's perceived need to breath (respiratory drive) and ability to do so (physiological capacity)
35
Mx of breathlessness
``` Aim to reduce perception Calm, logical approach Position patient upright Air flow across face Trial of O2 if hypoxic Non-drug approaches if feasible Treat underlying cause Morphine ```
36
Symptoms and signs of dying
Functional and physical ability - fatigue, increasing weakness, worsening mobility, inability to lift head off pillow Psychosocial and spiritual symptoms - concern for those left behind, fear of unknown, nearing death awareness, increased spiritual focus Reduced food and fluid intake Loss of ability to swallow Bowels and bladder - incontinence, oliguria to anuria urinary retention CVS changes - tachycardia, hypertension, cyanosis, mottling of skin, peripheral oedema Increasing physical symptoms - pain, N+V, resp symptoms, restlessness Resp - SOB, shallow and laboured breathing, apnea Decreasing level of consciousness
37
Anticpatory prescribing
Morphine 2.5-5mg sc PRN Midazolam - dyspnoa, agitation Glycopryrronium - secretions Levomepromazine - nausea
38
Side effects of opioid analgesia
``` Constipation - increase fibre and fluid - increase mobility if possible - faecal softeners (docusate sodium) with stimulants (senna) N+V - dopamine antagonist (domperidone, metoclopramide) Drowsiness and sedation Addiction unlikely if used correctly ```
39
Define consitpation
Hard faeces which are uncomfortable to pass - reduced frequency Colicky abdo pain, distention and N+V
40
Causes of constipation
Disease related – immobility, decreased food intake, intra-abdominal disease · Fluid depletion – decreased intake, sweating, vomiting · Weakness · Intestinal obstruction · Medication – opioids, diuretics, anti-cholinergics, 5-HT antagonists · Biochemical – hypercalcaemia, hypokalaemia · Psychological – pain of defaecation, lack of privacy
41
Complications of constipation
Overflow diarrhoea Acute urinary retention Haemorrhoids
42
Mx of constipation
High fibre high fluid diet Increase mobility Stimulants - sodium picosulfate, co-danthramer, senna Faecal softeners - docusate sodium, glycerol Osmotic - lactulose
43
Features of an amber care bundle
In cases where we are unsure if patients are going to recover - encourages continued care in aim of recovery while also planning for end of life