Pan-CP 2 Flashcards by E C

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Q

Adult T-cell leukemia/lymphoma (ATLL)

characteristic cell?
casuative agent?
geographic distribution?
disease caused by the same agent?

A

flower cell
HTLV-1, a retrovirus endemic to southern Japan, Brazil, South Africa, and the Caribbean. Spread thru sex, breastfeeding, blood
1:40 people infection w/ HTLV will develop ATLL
tropical spastic paraparesis – characterized by myelopathy/neuropathy, which progresses to lead to irreversible neurologic impairments

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Q

Burkitt:

characteristic translocation (hint: multiple partners)

A

c-Myc (8) translocates to:

IgH (14)
Ig-lambda light chain (2)
Ig-kappa light chain (22)

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Q

What blood components do the following stains stain?

Chloroacetate esterase
Napthyl esterase (non-specific esterase)
Myeloperoxidase
Sudan Black
Period acid-Schiff (PAS): ALL vs. AML

A

granulocytes
monocytes >>>> other lineages
immature and mature neutrophils; mature monocytes
myeloblasts/myelocytes; lipid vacuoles in Burkitt lymphoma
ALL: rosary beads; AML: diffuse granular hue

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Q

Dohle bodies

found in?
composed of?

A

infective and inflammatory states (especially burns)

normal pregnancy

congenital anomolies like May-Hegglin (MYH9)

composed of piled up RER – high RNA content. Can be destroyed w/ ribonuclease rx.

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Q

Follicular lymphoma

translocation?
characteristic stain? is it always +?
grading?
bone marrow involvement?

A

t(14;18) IgH:bcl-2
bcl-2 – however can be bcl-2 (especially in peds cases)
grade 1: 0-5 centroblasts/hpf
grade 2: 6-15 centroblasts/hpf
grade 3a: >15 centroblasts/hpf
grade 3b: all centroblasts
BM invovlement in 40-70%, usually paratrabecular

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