Pancytopenia

Question 1

What characterizes aplastic anaemia?

Answer 1

Pancytopenia and a hypoplastic bone marrow.

Question 2

What is the peak incidence age for acquired aplastic anaemia?

Answer 2

30 years old.

Question 3

What are the features of aplastic anaemia?

Answer 3

Normochromic, normocytic anaemia; leukopenia with lymphocytes relatively spared; thrombocytopenia.

Question 4

What may be the presenting feature of acute lymphoblastic or myeloid leukaemia?

Answer 4

Thrombocytopenia.

Question 5

What conditions may develop in a minority of aplastic anaemia patients?

Answer 5

Paroxysmal nocturnal haemoglobinuria or myelodysplasia.

Question 6

What are the idiopathic causes of aplastic anaemia?

Answer 6

Idiopathic causes.

Question 7

What congenital conditions are associated with aplastic anaemia?

Answer 7

Fanconi anaemia and dyskeratosis congenita.

Question 8

What drugs can cause aplastic anaemia?

Answer 8

Cytotoxics, chloramphenicol, sulphonamides, phenytoin, gold.

Question 9

What toxins are known to cause aplastic anaemia?

Answer 9

Benzene.

Question 10

What infections can lead to aplastic anaemia?

Answer 10

Parvovirus and hepatitis.

Question 11

What environmental factor is a cause of aplastic anaemia?

Answer 11

Radiation.

Question 12

What characterizes aplastic anaemia?

Answer 12

Pancytopenia and a hypoplastic bone marrow.

Question 13

What is the peak incidence age for acquired aplastic anaemia?

Answer 13

30 years old.

Question 14

What are the features of aplastic anaemia?

Answer 14

Normochromic, normocytic anaemia; leukopenia with lymphocytes relatively spared; thrombocytopenia.

Question 15

What may be the presenting feature of acute lymphoblastic or myeloid leukaemia?

Answer 15

Thrombocytopenia.

Question 16

What conditions may develop in a minority of aplastic anaemia patients?

Answer 16

Paroxysmal nocturnal haemoglobinuria or myelodysplasia.

Question 17

What are the idiopathic causes of aplastic anaemia?

Answer 17

Idiopathic causes.

Question 18

What congenital conditions are associated with aplastic anaemia?

Answer 18

Fanconi anaemia and dyskeratosis congenita.

Question 19

What drugs can cause aplastic anaemia?

Answer 19

Cytotoxics, chloramphenicol, sulphonamides, phenytoin, gold.

Question 20

What toxins are known to cause aplastic anaemia?

Answer 20

Benzene.

Question 21

What infections can lead to aplastic anaemia?

Answer 21

Parvovirus and hepatitis.

Question 22

What environmental factor is a cause of aplastic anaemia?

Answer 22

Radiation.

Question 23

What is drug-induced pancytopaenia?

Answer 23

Pancytopaenia caused by various drugs.

Question 24

What are some cytotoxic drugs that can cause pancytopaenia?

Answer 24

Cytotoxic drugs.

Question 25

Which antibiotics are known to cause pancytopaenia?

Answer 25

Trimethoprim, chloramphenicol.

Question 26

What anti-rheumatoid drugs can lead to pancytopaenia?

Answer 26

Gold, penicillamine.

Question 27

What is a drug that causes both agranulocytosis and pancytopaenia?

Answer 27

Carbimazole. ## Footnote Causes both agranulocytosis and pancytopaenia.

Question 28

Which anti-epileptic drug can cause pancytopaenia?

Answer 28

Carbamazepine.

Question 29

What sulphonylurea is associated with pancytopaenia?

Answer 29

Tolbutamide.

Question 30

What is drug-induced pancytopaenia?

Answer 30

Pancytopaenia caused by various drugs.

Question 31

What are some cytotoxic drugs that can cause pancytopaenia?

Answer 31

Cytotoxic drugs.

Question 32

Which antibiotics are known to cause pancytopaenia?

Answer 32

Trimethoprim, chloramphenicol.

Question 33

What anti-rheumatoid drugs can lead to pancytopaenia?

Answer 33

Gold, penicillamine.

Question 34

What is a drug that causes both agranulocytosis and pancytopaenia?

Answer 34

Carbimazole. ## Footnote Causes both agranulocytosis and pancytopaenia.

Question 35

Which anti-epileptic drug can cause pancytopaenia?

Answer 35

Carbamazepine.

Question 36

What sulphonylurea is associated with pancytopaenia?

Answer 36

Tolbutamide.